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Cited by 201

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Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage

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Torres-Padilla, Maria-Elena, Chambers, Ian·2014·Development
DOI 10.1242/dev.102624
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Abstract

When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self-renew or commit towards differentiation. Recent findings have provided new insight into the underlying causes of this heterogeneity, which we summarise here using Nanog, a key regulator of pluripotency, as a model gene. We discuss the role of transcription factor heterogeneity in facilitating the intrinsically dynamic and stochastic nature of the pluripotency network, which in turn provides a potential benefit to a population of cells that needs to balance cell fate decisions.

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Cited by

Metadata

Authors
Torres-Padilla, M.-E., & Chambers, I.
Venue
Development
Publisher
The Company of Biologists
Published
2014-06-01
Volume
141
Issue
11
Pages
2173-2181
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.102624
OpenAlex
W2064805149
Cited by
201
References
10
FWCI
10.83
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by/3.0 (vor, 2288 d)

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