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Cited by 1,174

The DOI matches its Crossref record.

The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo

Crossley, Philip H., Martin, Gail R.·1995·Development
DOI 10.1242/dev.121.2.439
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Abstract

Evidence is accumulating that members of the FGF gene family provide signals that act locally to regulate growth and patterning in vertebrate embryos. In this report, we provide a detailed analysis of the mouse Fgf8 gene. We have mapped the Fgf8 locus to the distal region of mouse chromosome 19, and sequenced the 5′coding region of the gene. Our data identify a new coding exon, and locate multiple splice donor and splice acceptor sites that can be used to produce at least seven transcripts encoding a family of secreted FGF8 proteins with different N termini. From these results, it appears that Fgf8 is structurally the most complex member of the FGF family described to date. In the embryo, many of the regions in which Fgf8 RNA is localized are known to direct outgrowth and patterning, including the apical ectodermal ridge of the limb bud, the primitive streak and tail bud, the surface ectoderm overlying the facial primorida and the midbrain-hindbrain junction, suggesting that FGF8 may be a component of the regulatory signals that emanate from these regions.

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Metadata

Authors
Crossley, P. H., & Martin, G. R.
Venue
Development
Publisher
The Company of Biologists
Published
1995-02-01
Volume
121
Issue
2
Pages
439-451
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.121.2.439
OpenAlex
W1922106993
Cited by
1,174
References
0
FWCI
22.97
Type
journal article
Language
en
Open access
closed

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