The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Exosomes in developmental signalling
Open accessAbstract
In order to achieve coordinated growth and patterning during development, cells must communicate with one another, sending and receiving signals that regulate their activities. Such developmental signals can be soluble, bound to the extracellular matrix, or tethered to the surface of adjacent cells. Cells can also signal by releasing exosomes – extracellular vesicles containing bioactive molecules such as RNA, DNA and enzymes. Recent work has suggested that exosomes can also carry signalling proteins, including ligands of the Notch receptor and secreted proteins of the Hedgehog and WNT families. Here, we describe the various types of exosomes and their biogenesis. We then survey the experimental strategies used so far to interfere with exosome formation and critically assess the role of exosomes in developmental signalling.
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Citations
Cites
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“Exosomes have subsequently been shown to be secreted from many other cell types and have been suggested to contribute to a variety of physiological processes (Box 2), such as stimulatory and tolerogenic responses in the immune system (Chaput and Thery, 2011), tumour progression and metastasis (Costa-Silva et al., 2015…”
Background
Cited by
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
Nusse, R., & Clevers, H. (2017) · Cell · doi:10.1016/j.cell.2017.05.016 · Cited by 4,342
Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003
Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance
Mashouri, L., Yousefi, H., Aref, A. R., Ahadi, A. M., Molaei, F., & Alahari, S. K. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0991-5 · Cited by 1,363
ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes
Larios, J., Mercier, V., Roux, A., & Gruenberg, J. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201904113 · Cited by 422
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Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds
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Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo
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Exosomes in Angiogenesis and Anti-angiogenic Therapy in Cancers
Olejarz, W., Kubiak-Tomaszewska, G., Chrzanowska, A., & Lorenc, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165840 · Cited by 299
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Metadata
- Authors
- McGough, I. J., & Vincent, J.-P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2016-07-15
- Volume
- 143
- Issue
- 14
- Pages
- 2482-2493
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2502341044
- Cited by
- 208
- References
- 21
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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