Wnt signalling: variety at the core

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912

Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma

Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., & Clevers, H. (1997) · Science · doi:10.1126/science.275.5307.1784 · Cited by 2,905

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Korinek, V., Barker, N., Moerer, P., van Donselaar, E., Huls, G., Peters, P. J., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,581

Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF

van de Wetering, M., Cavallo, R., Dooijes, D., van Beest, M., van Es, J., Loureiro, J., Ypma, A., Hursh, D., Jones, T., Bejsovec, A., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81925-x · Cited by 1,202

Alternative Splicing: New Insights from Global Analyses

Blencowe, B. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.023 · Cited by 1,130

Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

DasGupta, R., & Fuchs, E. (1999) · Development · doi:10.1242/dev.126.20.4557 · Cited by 1,000

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

van Genderen, C., Okamura, R. M., Fariñas, I., Quo, R. G., Parslow, T. G., Bruhn, L., & Grosschedl, R. (1994) · Genes & Development · doi:10.1101/gad.8.22.2691 · Cited by 965

Sumo, ubiquitin's mysterious cousin

Müller, S., Hoege, C., Pyrowolakis, G., & Jentsch, S. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35056591 · Cited by 764

Wnt and calcium signaling: β-Catenin-independent pathways

Kohn, A. D., & Moon, R. T. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.06.022 · Cited by 730

Self-Renewal and Cancer of the Gut: Two Sides of a Coin

Radtke, F., & Clevers, H. (2005) · Science · doi:10.1126/science.1104815 · Cited by 690

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

Travis, A., Amsterdam, A., Belanger, C., & Grosschedl, R. (1991) · Genes & Development · doi:10.1101/gad.5.5.880 · Cited by 614

Wnt signaling: is the party in the nucleus?

Willert, K., & Jones, K. A. (2006) · Genes & Development · doi:10.1101/gad.1424006 · Cited by 589

Links between signal transduction, transcription and adhesion in epithelial bud development

Jamora, C., DasGupta, R., Kocieniewski, P., & Fuchs, E. (2003) · Nature · doi:10.1038/nature01458 · Cited by 567

Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin

Merrill, B. J., Gat, U., DasGupta, R., & Fuchs, E. (2001) · Genes & Development · doi:10.1101/gad.891401 · Cited by 558

β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation

Daniels, D. L., & Weis, W. I. (2005) · Nature Structural & Molecular Biology · doi:10.1038/nsmb912 · Cited by 551

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

Sachdev, S., Bruhn, L., Sieber, H., Pichler, A., Melchior, F., & Grosschedl, R. (2001) · Genes & Development · doi:10.1101/gad.944801 · Cited by 547

The hair cycle

Alonso, L., & Fuchs, E. (2006) · Journal of Cell Science · doi:10.1242/jcs.02793 · Cited by 539

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

van de Wetering, M., Oosterwegel, M., Dooijes, D., & Clevers, H. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07928.x · Cited by 538

An HMG-box-containing T-cell factor required for thymocyte differentiation

Verbeek, S., Izon, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., Watering, M. V. D., Oosterwegel, M., Wilson, A., Robson MacDonald, H., & Clevers, H. (1995) · Nature · doi:10.1038/374070a0 · Cited by 514

Wnt signaling: complexity at the surface

Cadigan, K. M., & Liu, Y. I. (2006) · Journal of Cell Science · doi:10.1242/jcs.02826 · Cited by 486

Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate.

Zhou, P., Byrne, C., Jacobs, J., & Fuchs, E. (1995) · Genes & Development · doi:10.1101/gad.9.6.700 · Cited by 474

Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice

Galceran, J., Farinas, I., Depew, M. J., Clevers, H., & Grosschedl, R. (1999) · Genes & Development · doi:10.1101/gad.13.6.709 · Cited by 462

β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

Hovanes, K., Li, T. W. H., Munguia, J. E., Truong, T., Milovanovic, T., Lawrence Marsh, J., Holcombe, R. F., & Waterman, M. L. (2001) · Nature Genetics · doi:10.1038/ng0501-53 · Cited by 458

Synergy Between Tumor Suppressor APC and the β-Catenin-Tcf4 Target Tcf1

Roose, J., Huls, G., Beest, M. V., Moerer, P., Horn, K. V. D., Goldschmeding, R., Logtenberg, T., & Clevers, H. (1999) · Science · doi:10.1126/science.285.5435.1923 · Cited by 456

Diversity of LEF/TCF action in development and disease

Arce, L., Yokoyama, N. N., & Waterman, M. L. (2006) · Oncogene · doi:10.1038/sj.onc.1210056 · Cited by 438

Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells

Lowry, W. E., Blanpain, C., Nowak, J. A., Guasch, G., Lewis, L., & Fuchs, E. (2005) · Genes & Development · doi:10.1101/gad.1324905 · Cited by 392

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

Waltzer, L., & Bienz, M. (1998) · Nature · doi:10.1038/26785 · Cited by 362

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

Waterman, M. L., Fischer, W. H., & Jones, K. A. (1991) · Genes & Development · doi:10.1101/gad.5.4.656 · Cited by 359

Regulation of Wnt Signaling by Sox Proteins

Zorn, A. M., Barish, G. D., Williams, B. O., Lavender, P., Klymkowsky, M. W., & Varmus, H. E. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80200-2 · Cited by 342

Transient activation of β-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

Celso, C. L., Prowse, D. M., & Watt, F. M. (2004) · Development · doi:10.1242/dev.01052 · Cited by 339

Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1

Okamura, R. M., Sigvardsson, M., Galceran, J., Verbeek, S., Clevers, H., & Grosschedl, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80454-9 · Cited by 333

WNT signalling and haematopoiesis: a WNT–WNT situation

Staal, F. J. T., & Clevers, H. C. (2005) · Nature Reviews Immunology · doi:10.1038/nri1529 · Cited by 330

Repression of Nanog Gene Transcription by Tcf3 Limits Embryonic Stem Cell Self-Renewal

Pereira, L., Yi, F., & Merrill, B. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00368-06 · Cited by 315

The canonical Wnt signalling pathway and its APC partner in colon cancer development

Schneikert, J., & Behrens, J. (2007) · Gut · doi:10.1136/gut.2006.093310 · Cited by 290

β-catenin, MAPK and Smad signaling during early Xenopus development

Schohl, A., & Fagotto, F. (2002) · Development · doi:10.1242/dev.129.1.37 · Cited by 269

XCtBP is a XTcf-3 co-repressor with roles throughout Xenopus development

Brannon, M., Brown, J. D., Bates, R., Kimelman, D., & Moon, R. T. (1999) · Development · doi:10.1242/dev.126.14.3159 · Cited by 247

Tcf3: a transcriptional regulator of axis induction in the early embryo

Merrill, B. J., Pasolli, H. A., Polak, L., Rendl, M., García-García, M. J., Anderson, K. V., & Fuchs, E. (2004) · Development · doi:10.1242/dev.00935 · Cited by 242

Human Naive CD8 T Cells Down-Regulate Expression of the WNT Pathway Transcription Factors Lymphoid Enhancer Binding Factor 1 and Transcription Factor 7 (T Cell Factor-1) following Antigen Encounter In Vitro and In Vivo

Willinger, T., Freeman, T., Herbert, M., Hasegawa, H., McMichael, A. J., & Callan, M. F. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.3.1439 · Cited by 200

Extensive Alternative Splicing and Dual Promoter Usage Generate Tcf-1 Protein Isoforms with Differential Transcription Control Properties

De Wetering, M. V., Castrop, J., Korinek, V., & Clevers, H. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.745 · Cited by 191

Sumoylation is involved in beta-catenin-dependent activation of Tcf-4

Yamamoto, H. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg204 · Cited by 173

The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines.

Duval, A., Rolland, S., Tubacher, E., Bui, H., Thomas, G. D., & Hamelin, R. (2000) · PubMed · Cited by 171

C‐terminal‐binding protein directly activates and represses Wnt transcriptional targets in Drosophila

Fang, M., Li, J., Blauwkamp, T., Bhambhani, C., Campbell, N., & Cadigan, K. M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601153 · Cited by 164

The APC Tumor Suppressor Binds to C-Terminal Binding Protein to Divert Nuclear β-Catenin from TCF

Hamada, F., & Bienz, M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.022 · Cited by 159

Human sebaceous tumors harbor inactivating mutations in LEF1

Takeda, H., Lyle, S. R., Lazar, A. J., Zouboulis, C. C., Smyth, I., & Watt, F. M. (2006) · Nature Medicine · doi:10.1038/nm1386 · Cited by 153

The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha enhancer in T cells.Preprint

Carlsson, P., Waterman, M. L., & Jones, K. A. (1993) · Genes & Development · doi:10.1101/gad.7.12a.2418 · Cited by 151

Armadillo/β-catenin signals in the nucleus – proof beyond a reasonable doubt?

Bienz, M., & Clevers, H. C. (2003) · Nature Cell Biology · doi:10.1038/ncb0303-179 · Cited by 149

Sequence-specific HMG box factors recognize 10-12 base pair minor groove motifs

van Beest, M., Dooijes, D., van de Wetering, M. D., Kjærulff, S., Bonvin, A. M. J. J., Nielsen, O., & Clevers, H. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004102200 · Cited by 130

Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules

Weerkamp, F., Baert, M. R. M., Naber, B. A. E., Koster, E. E. L., de Haas, E. F. E., Atkuri, K. R., van Dongen, J. J. M., Herzenberg, L. A., & Staal, F. J. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511299103 · Cited by 123

Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer

Shulewitz, M. J., Soloviev, I., Wu, T., Koeppen, H., Polakis, P. G., & Sakanaka, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209470 · Cited by 111

Wnt Activation and Alternative Promoter Repression of LEF1 in Colon Cancer

Li, T. W. H., Ting, J.-H. T., Yokoyama, N. N., Bernstein, A., van de Wetering, M., & Waterman, M. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00105-06 · Cited by 107

Repression of organizer genes in dorsal and ventralXenopuscells mediated by maternal XTcf3

Houston, D. W., Kofron, M. J., Resnik, E., Langland, R., Destrée, O., Wylie, C. C., & Heasman, J. (2002) · Development · doi:10.1242/dev.129.17.4015 · Cited by 107

Distinct roles forXenopusTcf/Lef genes in mediating specific responses to Wnt/β-catenin signalling in mesoderm development

Liu, F., van den Broek, O., Destrée, O., & Hoppler, S. (2005) · Development · doi:10.1242/dev.02152 · Cited by 105

Sequence-specific High Mobility Group Box Factors Recognize 10–12-Base Pair Minor Groove Motifs

van Beest, M., Dooijes, D., van de Wetering, M., Kjærulff, S., Bonvin, A. M. J. J., Nielsen, O., & Clevers, H. C. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61506-1 · Cited by 101

Identification of a Promoter-specific Transcriptional Activation Domain at the C Terminus of the Wnt Effector Protein T-cell Factor 4

Hecht, A., & Stemmler, M. P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210081200 · Cited by 92

HIC1 attenuates Wnt signaling by recruitment of TCF‐4 and β‐catenin to the nuclear bodies

Valenta, T., Lukas, J., Doubravska, L., Fafilek, B., & Korinek, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601147 · Cited by 91

Dissecting nuclear Wingless signalling: Recruitment of the transcriptional co-activator Pygopus by a chain of adaptor proteins

Städeli, R., & Basler, K. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.07.004 · Cited by 91

Zygotic Wnt Activity Is Required for Brachyury Expression in the Early Xenopus laevis Embryo

Vonica, A., & Gumbiner, B. M. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0786 · Cited by 83

A New β-Catenin-dependent Activation Domain in T Cell Factor

Atcha, F. A., Munguia, J. E., Li, T. W. H., Hovanes, K., & Waterman, M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213218200 · Cited by 79

A role for maternal β‐catenin in early mesoderm induction in Xenopus

Schohl, A., & Fagotto, F. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg328 · Cited by 74

Desumoylation Activity of Axam, a Novel Axin-Binding Protein, Is Involved in Downregulation of β-Catenin

Kadoya, T., Yamamoto, H., Suzuki, T., Yukita, A., Fukui, A., Michiue, T., Asahara, T., Tanaka, K., Asashima, M., & Kikuchi, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3803-3819.2002 · Cited by 71

The canonical Wnt pathway in embryonic axis polarity

Croce, J. C., & McClay, D. R. (2006) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2006.04.004 · Cited by 70

Redundant functions of TCF‐1 and LEF‐1 during T and NK cell development, but unique role of TCF‐1 for Ly49 NK cell receptor acquisition

Held, W., Clevers, H. C., & Grosschedl, R. (2003) · European Journal of Immunology · doi:10.1002/eji.200323840 · Cited by 69

Functional Diversity of Xenopus Lymphoid Enhancer Factor/T-cell Factor Transcription Factors Relies on Combinations of Activating and Repressing Elements

Gradl, D., König, A. O., & Wedlich, D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107055200 · Cited by 62

Identification of Two Regulatory Elements within the High Mobility Group Box Transcription Factor XTCF-4

Pukrop, T., Gradl, D., Henningfeld, K. A., Knöchel, W., Wedlich, D., & Kühl, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007533200 · Cited by 61

Difference in XTcf-3 dependency accounts for change in response to β-catenin-mediated Wnt signalling inXenopusblastula

Hamilton, F. S., Wheeler, G. N., & Hoppler, S. (2001) · Development · doi:10.1242/dev.128.11.2063 · Cited by 59

Autoregulation of canonical Wnt signaling controls midbrain development

Kunz, M., Herrmann, M., Wedlich, D., & Gradl, D. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.06.015 · Cited by 52

Maternal XTcf1 and XTcf4 have distinct roles in regulating Wnt target genes

Standley, H. J., Destrée, O., Kofron, M. J., Wylie, C., & Heasman, J. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.012 · Cited by 52

Expression and splice variant analysis of the zebrafish tcf4 transcription factor

Young, R., Reyes, A. E., & Allende, M. L. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00180-6 · Cited by 41

Ectopic activation of lymphoid high mobility group-box transcription factor TCF-1 and overexpression in colorectal cancer cells

Mayer, K., Hieronymus, T., Castrop, J., Clevers, H. C., & Ballhausen, W. G. (1997) · International Journal of Cancer · Cited by 34

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583

MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches

Kufe, D. W. (2013) · Oncogene · doi:10.1038/onc.2012.158 · Cited by 437

The functional consequences of alternative promoter use in mammalian genomes

Davuluri, R. V., Suzuki, Y., Sugano, S., Plass, C., & Huang, T. H.-M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.01.008 · Cited by 408

Wnt-Pathway Activation in Two Molecular Classes of Hepatocellular Carcinoma and Experimental Modulation by Sorafenib

Lachenmayer, A., Alsinet, C., Savic, R., Cabellos, L., Toffanin, S., Hoshida, Y., Villanueva, A., Minguez, B., Newell, P., Tsai, H.-W., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2322 · Cited by 306

Maintaining embryonic stem cell pluripotency with Wnt signaling

Sokol, S. Y. (2011) · Development · doi:10.1242/dev.066209 · Cited by 257