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Biological roles and mechanistic actions of co-repressor complexes

Jepsen, Kristen, Rosenfeld, Michael G.·2002·Journal of Cell Science
DOI 10.1242/jcs.115.4.689
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Abstract

Transcriptional repression, which plays a crucial role in diverse biological processes, is mediated in part by non-DNA-binding co-repressors. The closely related co-repressor proteins N-CoR and SMRT, although originally identified on the basis of their ability to associate with and confer transcriptional repression through nuclear receptors, have been shown to be recruited to many classes of transcription factor and are in fact components of multiple protein complexes containing histone deacetylase proteins. This association with histone deacetylase activity provides an important component of the mechanism that allows DNA-binding proteins interacting with N-CoR or SMRT to repress transcription of specific target genes. Both N-CoR and SMRT are important targets for cell signaling pathways, which influence their expression levels, subcellular localization and association with other proteins. Recently, the biological importance of these proteins has been revealed by studies of genetically engineered mice and human diseases such as acute promyelocytic leukemia (APL) and resistance to thyroid hormone(RTH).

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Metadata

Authors
Jepsen, K., & Rosenfeld, M. G.
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2002-02-15
Volume
115
Issue
4
Pages
689-698
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
DOI
10.1242/jcs.115.4.689
OpenAlex
W1952721216
Cited by
317
References
11
FWCI
10.15
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Biological roles and mechanistic actions of co-repressor complexes. https://app.cochat.ai/papers/10.1242/jcs.115.4.689
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Jepsen, K., & Rosenfeld, M. G. (2002). Biological roles and mechanistic actions of co-repressor complexes. Journal of Cell Science. https://doi.org/10.1242/jcs.115.4.689

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