CoChat
Sign Up
Cited by 143Ovarian function and disordersEndometriosis Research and TreatmentReproductive Biology and Fertility

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

Recent advances in the understanding and management of polycystic ovary syndrome

Open access
Rocha, Ana L., Oliveira, Flávia R., Azevedo, Rosana C., Silva, Virginia A., Peres, Thais M., Candido, Ana L., Gomes, Karina B., Reis, Fernando M.·2019·F1000Research
DOI 10.12688/f1000research.15318.1PMC PMC6489978
Open this paper in CoChat — free accountOpen PDF

Abstract

Polycystic ovary syndrome (PCOS) is a multifaceted condition characterized by chronic anovulation and excess ovarian activity, in contrast to other causes of anovulation that involve ovarian dormancy or primary insufficiency. Recent studies indicated that PCOS is associated with low-grade chronic inflammation and that women with PCOS are at increased risk of non-alcoholic fatty liver disease. The inflammatory and metabolic derangements associated with PCOS are explained in part by the coexistence of insulin resistance and obesity but are further fueled by the androgen excess. New insights into the regulation of hormones and cytokines in muscle and fat tissue support the concept that PCOS is a systemic syndrome. The therapeutic plan should be tailored to the patient phenotype, complaints, and reproductive desire. Of note, the aromatase inhibitor letrozole seems to be more effective than the reference drug clomiphene citrate to treat infertility due to PCOS. Integral management by a multidisciplinary team may help the patients to adhere to lifestyle interventions and thereby reduce body adiposity and recover their metabolic and reproductive health.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.12688/f1000research.15318.1

Cites

73 of 73 references verified0 citation errors · 0 not checkable

Statistics

Figures

Figure 1. Schematic representation of some pathophysiological mechanisms of polycystic ovary syndrome. The main clinical manifestations are shown in rectangular boxes. Androgens are responsible for dermatological symptoms, while sustained estrogen production by the ovaries and subcutaneous fat without progesterone opposition produces menstrual irregularity and increases the risk of endometrial hyperplasia. Adipokines and myokines may also be involved in the metabolic alterations associated with the syndrome. Insulin resistance and the compensatory hyperinsulinemia are central mechanisms that perpetuate anovulation and lead to metabolic complications. AMH, anti-Müllerian hormone; FSH, follicle-stimulating hormone; IGF-I, insulin-like growth factor I; LH, luteinizing hormone; NAFLD, non-alcoholic fatty liver disease; SHBG, sex hormone–binding globulin.
Figure 1. Schematic representation of some pathophysiological mechanisms of polycystic ovary syndrome. The main clinical manifestations are shown in rectangular boxes. Androgens are responsible for dermatological symptoms, while sustained estrogen production by the ovaries and subcutaneous fat without progesterone opposition produces menstrual irregularity and increases the risk of endometrial hyperplasia. Adipokines and myokines may also be involved in the metabolic alterations associated with the syndrome. Insulin resistance and the compensatory hyperinsulinemia are central mechanisms that perpetuate anovulation and lead to metabolic complications. AMH, anti-Müllerian hormone; FSH, follicle-stimulating hormone; IGF-I, insulin-like growth factor I; LH, luteinizing hormone; NAFLD, non-alcoholic fatty liver disease; SHBG, sex hormone–binding globulin.CC BY · PubMed Central
Figure 2. Patient-centered care by a multidisciplinary team may help reach the main goals of polycystic ovary syndrome management. These goals are symptom relief, safe fertility planning, general well-being, and prevention of long-term complications.
Figure 2. Patient-centered care by a multidisciplinary team may help reach the main goals of polycystic ovary syndrome management. These goals are symptom relief, safe fertility planning, general well-being, and prevention of long-term complications.CC BY · PubMed Central
Figure 3. Objectives of assessing the quality of life in women with polycystic ovary syndrome.
Figure 3. Objectives of assessing the quality of life in women with polycystic ovary syndrome.CC BY · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

1 retracted

Cited by

Sorted by citations

See all 143

Related

See all

Metadata

Authors
Rocha, A. L., Oliveira, F. R., Azevedo, R. C., Silva, V. A., Peres, T. M., Candido, A. L., Gomes, K. B., & Reis, F. M.
Affiliations
Universidade Federal de Minas Gerais (BR)
ORCID
Venue
F1000Research
Publisher
F1000 Research Ltd
Published
2019-04-26
Volume
8
Pages
565
ISSN
2046-1402 (ISSN-L)
DOI
10.12688/f1000research.15318.1
PMC
PMC6489978
OpenAlex
W2940491682
Cited by
142
References
73
Citations by year
2026: 7 · 2025: 24 · 2024: 22 · 2023: 30 · 2022: 29 · 2021: 18 · 2020: 9 · 2019: 2
FWCI
2.05
Type
journal article
Language
en
Open access
Licence
Locations
  • F1000Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Keywords
polycystic ovary syndrome, anovulation, low-grade inflammation, non-alcoholic fatty liver disease, insulin resistance, obesity, hyperandrogenism, systemic inflammation, letrozole, clomiphene citrate, multidisciplinary management, lifestyle intervention, adiposity
MeSH terms
Letrozole, Clomiphene, Female, Humans, Insulin Resistance, Obesity, Polycystic Ovary Syndrome, Aromatase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review