The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System
Open accessAbstract
Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern. Here we report a novel role of an alternatively spliced hypervariable immunoglobulin domain-encoding gene, Dscam, in generating a broad range of PRRs implicated in immune defense in the malaria vector Anopheles gambiae. The mosquito Down syndrome cell adhesion molecule gene, AgDscam, has a complex genome organization with 101 exons that can produce over 31,000 potential alternative splice forms with different combinations of adhesive domains and interaction specificities. AgDscam responds to infection by producing pathogen challenge-specific splice form repertoires. Transient silencing of AgDscam compromises the mosquito's resistance to infections with bacteria and the malaria parasite Plasmodium. AgDscam is mediating phagocytosis of bacteria with which it can associate and defend against in a splice form-specific manner. AgDscam is a hypervariable PRR of the A. gambiae innate immune system.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Nucleic acid techniques in bacterial systematics
Stackebrandt, E. S., & Goodfellow, M. (1991) · Wiley eBooks · Cited by 9,460
Lane, D. (1991) · Medical Entomology and Zoology · Cited by 8,187
The immune response of Drosophila
Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553
Drosophila innate immunity: an evolutionary perspective
Hoffmann, J. A., & Reichhart, J.-M. (2002) · Nature Immunology · doi:10.1038/ni0202-121 · Cited by 1,142
Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity
Schmucker, D., Clemens, J. C., Shu, H., Worby, C. A., Xiao, J., Muda, M., Dixon, J. E., & Zipursky, S. L. (2000) · Cell · doi:10.1016/s0092-8674(00)80878-8 · Cited by 1,104
The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity
Ramirez, J. L., Garver, L. S., Brayner, F. A., Alves, L. C., Rodrigues, J., Molina-Cruz, A., & Barillas-Mury, C. (2014) · Journal of Innate Immunity · doi:10.1159/000353765 · Cited by 1,084
Immunity-Related Genes and Gene Families in Anopheles gambiae
Christophides, G. K., Zdobnov, E., Barillas-Mury, C., Birney, E., Blandin, S., Blass, C., Brey, P. T., Collins, F. H., Danielli, A., Dimopoulos, G., et al. (2002) · Science · doi:10.1126/science.1077136 · Cited by 967
Self-citationThe Toll and Imd pathways are the major regulators of the immune response in Drosophila
De Gregorio, E. (2002) · The EMBO Journal · doi:10.1093/emboj/21.11.2568 · Cited by 934
Extensive Diversity of Ig-Superfamily Proteins in the Immune System of Insects
Watson, F. L., Püttmann-Holgado, R., Thomas, F., Lamar, D. L., Hughes, M., Kondo, M., Rebel, V. I., & Schmucker, D. (2005) · Science · doi:10.1126/science.1116887 · Cited by 686
The Drosophila immune system detects bacteria through specific peptidoglycan recognition
Leulier, F., Parquet, C., Pili-Floury, S., Ryu, J.-H., Caroff, M., Lee, W.-J., Mengin-Lecreulx, D., & Lemaitre, B. (2003) · Nature Immunology · doi:10.1038/ni922 · Cited by 634
Choe, K.-M., Werner, T., Stöven, S., Hultmark, D., & Anderson, K. V. (2002) · Science · doi:10.1126/science.1070216 · Cited by 607
Blandin, S., Shiao, S.-H., Moita, L. F., Janse, C. J., Waters, A. P., Kafatos, F. C., & Levashina, E. A. (2004) · Cell · doi:10.1016/s0092-8674(04)00173-4 · Cited by 606
Drosophila immunity: paths and patterns
Hultmark, D. (2003) · Current Opinion in Immunology · doi:10.1016/s0952-7915(02)00005-5 · Cited by 600
Levashina, E. A., Moita, L. F., Blandin, S., Vriend, G., Lagueux, M., & Kafatos, F. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00267-7 · Cited by 551
A family of peptidoglycan recognition proteins in the fruit fly Drosophila melanogaster
Werner, T., Liu, G., Kang, D., Ekengren, S., Steiner, H., & Hultmark, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.25.13772 · Cited by 550
Franke-Fayard, B., Trueman, H., Ramesar, J., Mendoza, J., van der Keur, M., van der Linden, R., Sinden, R. E., Waters, A. P., & Janse, C. J. (2004) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2004.04.007 · Cited by 474
Han, Y. S. (2000) · The EMBO Journal · doi:10.1093/emboj/19.22.6030 · Cited by 381
Coagulation in arthropods: defence, wound closure and healing
Theopold, U., Schmidt, O., Söderhäll, K., & Dushay, M. S. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.03.004 · Cited by 370
D rosophila : The Genetics of Innate Immune Recognition and Response
Brennan, C. A., & Anderson, K. V. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104626 · Cited by 356
Reverse genetics in the mosquito Anopheles gambiae : targeted disruption of the Defensin gene
Blandin, S., Moita, L. F., Köcher, T., Wilm, M., Kafatos, F. C., & Levashina, E. A. (2002) · EMBO reports · doi:10.1093/embo-reports/kvf180 · Cited by 355
Immune signalling in neural development, synaptic plasticity and disease
Boulanger, L. M., & Shatz, C. J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1428 · Cited by 334
Wojtowicz, W. M., Flanagan, J. J., Millard, S. S., Zipursky, S. L., & Clemens, J. C. (2004) · Cell · doi:10.1016/j.cell.2004.08.021 · Cited by 331
Dimopoulos, G., Christophides, G. K., Meister, S., Schultz, J., White, K. P., Barillas-Mury, C., & Kafatos, F. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092274999 · Cited by 300
Self-citationGraveley, B. R. (2005) · Cell · doi:10.1016/j.cell.2005.07.028 · Cited by 295
Adaptive innate immunity? Responsive-mode prophylaxis in the mealworm beetle,Tenebrio molitor
Moret, Y., & Siva-Jothy, M. T. (2003) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2003.2511 · Cited by 284
Müller, H.-M., Dimopoulos, G., Blass, C., & Kafatos, F. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.11727 · Cited by 270
Self-citationStochastic yet biased expression of multiple Dscam splice variants by individual cells
Neves, G., Zucker, J., Daly, M., & Chess, A. (2004) · Nature Genetics · doi:10.1038/ng1299 · Cited by 268
Lundquist, E. A., Reddien, P. W., Hartwieg, E., Horvitz, H. R., & Bargmann, C. I. (2001) · Development · doi:10.1242/dev.128.22.4475 · Cited by 242
Functional Dissection of an Innate Immune Response by a Genome-Wide RNAi Screen
Foley, E., & O'Farrell, P. H. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020203 · Cited by 238
Manfruelli, P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.12.3380 · Cited by 219
Lee, W. J., Lee, J. D., Kravchenko, V. V., Ulevitch, R. J., & Brey, P. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7888 · Cited by 211
Functional Genomic Analysis of Midgut Epithelial Responses in Anopheles during Plasmodium Invasion
Vlachou, D., Schlegelmilch, T., Christophides, G. K., & Kafatos, F. C. (2005) · Current Biology · doi:10.1016/j.cub.2005.06.044 · Cited by 199
Weiner, O. D., Rentel, M. C., Ott, A., Brown, G. E., Jedrychowski, M., Yaffe, M. B., Gygi, S. P., Cantley, L. C., Bourne, H. R., & Kirschner, M. W. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040038 · Cited by 178
Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe
Zhu, H., Hummel, T., Clemens, J. C., Berdnik, D., Zipursky, S. L., & Luo, L. (2006) · Nature Neuroscience · doi:10.1038/nn1652 · Cited by 174
Nair, S. V., Del Valle, H., Gross, P. S., Terwilliger, D. P., & Smith, L. C. (2005) · Physiological Genomics · doi:10.1152/physiolgenomics.00052.2005 · Cited by 173
Neuronal plasticity and cellular immunity: shared molecular mechanisms
Boulanger, L. M., Huh, G. S., & Shatz, C. J. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00251-8 · Cited by 171
Insect immunity and its implication in mosquito-malaria interactions
Dimopoulos, G. (2003) · Cellular Microbiology · doi:10.1046/j.1462-5822.2003.00252.x · Cited by 168
Self-citationBlood cells of Drosophila: cell lineages and role in host defence
Meister, M. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.11.002 · Cited by 168
Memory in the innate and adaptive immune systems
Kurtz, J. (2004) · Microbes and Infection · doi:10.1016/j.micinf.2004.10.002 · Cited by 135
Drevets, D. A., & Campbell, P. A. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90289-r · Cited by 133
Alternative Splicing of the DrosophilaDscamPre-mRNA Is Both Temporally and Spatially Regulated
Celotto, A. M., & Graveley, B. R. (2001) · Genetics · doi:10.1093/genetics/159.2.599 · Cited by 122
Natural insect host-parasite systems show immune priming and specificity: puzzles to be solved
Schmid‐Hempel, P. (2005) · BioEssays · doi:10.1002/bies.20282 · Cited by 118
Vogel, C., Teichmann, S. A., & Chothia, C. (2003) · Development · doi:10.1242/dev.00848 · Cited by 113
Tahar, R., Boudin, C., Thiery, I., & Bourgouin, C. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf664 · Cited by 101
Graveley, B. R., Kaur, A., Gunning, D., Zipursky, S. L., Rowen, L., & Clemens, J. C. (2004) · RNA · doi:10.1261/rna.7105504 · Cited by 89
Care and maintenance of anopheline mosquito colonies
Benedict, M. Q. (1997) · Springer eBooks · doi:10.1007/978-94-009-1535-0_1 · Cited by 85
Agarwala, K. L., Ganesh, S., Tsutsumi, Y., Suzuki, T., Amano, K., & Yamakawa, K. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5214 · Cited by 71
Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum?
Barlow, G. M., Micales, B. K., Chen, X., Lyons, G. E., & Korenberg, J. R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00307-8 · Cited by 58
Insects Diversify One Molecule to Serve Two Systems
Pasquier, L. D. (2005) · Science · doi:10.1126/science.1118828 · Cited by 52
Tracking the evolution of alternatively spliced exons within the Dscam family
Crayton, M. E., Powell, B. C., Vision, T., & Giddings, M. C. (2006) · BMC Evolutionary Biology · doi:10.1186/1471-2148-6-16 · Cited by 52
Generation of Recognition Diversity in the Nervous System
Schmucker, D., & Flanagan, J. G. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.004 · Cited by 39
The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis
Yimlamai, D., Konnikova, L., Moss, L. G., & Jay, D. G. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.001 · Cited by 38
Innate Immunity in Fruit Flies: A Textbook Example of Genomic Recycling
Govind, S., & Nehm, R. H. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020276 · Cited by 23
Cited by
Implication of the Mosquito Midgut Microbiota in the Defense against Malaria Parasites
Dong, Y., Manfredini, F., & Dimopoulos, G. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000423 · Cited by 801
Self-citationInsect immunology and hematopoiesis
Hillyer, J. F. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2015.12.006 · Cited by 561
Immune proteins in brain development and synaptic plasticity
Boulanger, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.001 · Cited by 555
Crompton, P. D., Moebius, J., Portugal, S., Waisberg, M., Hart, G., Garver, L. S., Miller, L. H., Barillas-Mury, C., & Pierce, S. K. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120220 · Cited by 317
Highly diversified innate receptor systems and new forms of animal immunity
Messier-Solek, C., Buckley, K. M., & Rast, J. P. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2009.11.007 · Cited by 87
Metadata
- Authors
- Dong, Y., Taylor, H. E., & Dimopoulos, G.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-06-20
- Volume
- 4
- Issue
- 7
- Pages
- e229
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2142903380
- Cited by
- 465
- References
- 54
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
