Observational research, randomised trials, and two views of medical science
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Two views exist of medical science, says the author, one emphasizing discovery and explanation, the other emphasizing evaluation of interventions.
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The strengths and limitations of methods used to conduct research with routinely collected data may be contentious.
“Because the strengths and limitations of methods used to conduct research with routinely collected data may be contentious, a clear description of a study’s objectives is essential [23,24].”
From The Reporting of Studies Conducted Using Observational Routinely-Collected Health Data (RECORD) statement. (2015) · cites this paper as [23]
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- Authors
- Vandenbroucke, J. P.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Vandenbroucke, Jan P
- ORCID
- Vandenbroucke, Jan P
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-03-11
- Volume
- 5
- Issue
- 3
- Pages
- e67
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- PMC
- PMC2265762
- OpenAlex
- W2090226269
- Cited by
- 416
- References
- 66
- Citations by year
- 2026: 15 · 2025: 5 · 2024: 15 · 2023: 32 · 2022: 22 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 14 · 2017: 14 · 2016: 17 · 2015: 26 · 2014: 20 · 2013: 36 · 2012: 31
- FWCI
- 30.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- London School of Hygiene and Tropical Medicine
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy and History of Science
- Health Sciences › Health Professions › Health Information Management › Methodologies in Health Research and Practice
- Keywords
- observational studies, randomised trials, medical sciences, intervention evaluation, philosophy of medicine
- MeSH terms
- Contraceptives, Oral, Evaluation Studies as Topic, Factor V, Female, Follow-Up Studies, Humans, Prospective Studies, Retrospective Studies, Case-Control Studies, Randomized Controlled Trials as Topic, Biomedical Research, Venous Thromboembolism
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