Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Developments of a water-maze procedure for studying spatial learning in the rat

Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature · doi:10.1038/369756a0 · Cited by 2,053

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892

Rapamycin promotes Schwann cell migration and nerve growth factor secretion

Yin, Y., Liu, F., Zhang, H., Zhang, K., Wang, X., & Li, S. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.130101 · Cited by 15

Stereoselective Synthesis of Rapamycin Fragment To Build a Macrocyclic Toolbox

Guduru, S. K. R., Jimmidi, R., Deora, G. S., & Arya, P. (2015) · Organic Letters · doi:10.1021/ol5034833 · Cited by 15

It may be possible to delay the onset of neurodegenerative diseases with an immunosuppressive drug (rapamycin)

Aso, E., & Ferrer, I. (2013) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2013.799129 · Cited by 15

The connection between autophagy and Alzheimer’s disease

Nechushtai, L., Chen, D., Dan, F., & Pinkas‐Kramarski, R. (2025) · Inflammation Research · doi:10.1007/s00011-025-02118-0 · Cited by 19

Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system

Bolukbasi, E., Woodling, N. S., Ivanov, D. K., Adcott, J., Foley, A., Rajasingam, A., Gittings, L. M., Aleyakpo, B., Niccoli, T., Thornton, J. M., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011491118 · Cited by 16

Effects of lifespan-extending interventions on cognitive healthspan

Čulig, L., Sahbaz, B. D., & Bohr, V. A. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2022.36 · Cited by 14

Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease

Sonsalla, M. M., & Lamming, D. W. (2023) · GeroScience · doi:10.1007/s11357-023-00782-w · Cited by 17

Autophagy and exosomes; inter-connected maestros in Alzheimer’s disease

Atya, H. B., Sharaf, N. M., Abdelghany, R. M., El-Helaly, S. N., & Taha, H. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01466-3 · Cited by 14

Novel prospects in targeting neurodegenerative disorders via autophagy

Khan, S., Upadhyay, S., & Hassan, M. I. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177060 · Cited by 15

How close is autophagy-targeting therapy for Alzheimer's disease to clinical use? A summary of autophagy modulators in clinical studies

Fernandes, S. M., Mayer, J., Nilsson, P., & Shimozawa, M. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1520949 · Cited by 17

Involvement of ‘stress–response’ kinase pathways in Alzheimer's disease progression

Mairet‐Coello, G., & Polleux, F. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.03.011 · Cited by 16

The Role of Aging in Alzheimer’s Disease

Kerchner, G. A., & Wyss‐Coray, T. (2015) · Springer eBooks · doi:10.1007/978-3-319-23246-1_7 · Cited by 14

TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics

Jensen, P., Myhre, C. L., Lassen, P. S., Metaxas, A., Khan, A. M., Lambertsen, K. L., Babcock, A. A., Finsen, B. R., Larsen, M. R., & Kempf, S. J. (2017) · Oncotarget · doi:10.18632/oncotarget.19428 · Cited by 14

NPD1 Enhances Autophagy and Reduces Hyperphosphorylated Tau and Amyloid-β42 by Inhibiting GSK3β Activation in N2a/APP695swe Cells

Dai, S.-Y., Zhou, F., Sun, J., & Li, Y. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210729 · Cited by 14

Is the Brain Undernourished in Alzheimer’s Disease?

Aquilani, R., Costa, A. C., Maestri, R., Ramusino, M. C., Perini, G., Boselli, M., Iadarola, P., Buonocore, D., Verri, M., Dossena, M., et al. (2022) · Nutrients · doi:10.3390/nu14091872 · Cited by 15

Dihydrotanshinone I Increase Amyloid-β Clearance and Decrease Tau Phosphorylation via Enhancing Autophagy

Bao, Z., Zhang, H., Jiao, H., Chu, X., Fu, J. X., & Wang, L. (2020) · Pharmacology · doi:10.1159/000503792 · Cited by 14

PS4DR: a multimodal workflow for identification and prioritization of drugs based on pathway signatures

Emon, M. A., Domingo‐Fernándéz, D., Hoyt, C. T., & Hofmann‐Apitius, M. (2020) · BMC Bioinformatics · doi:10.1186/s12859-020-03568-5 · Cited by 12

Beyond Host Defense: Deregulation of Drosophila Immunity and Age-Dependent Neurodegeneration

Arora, S., & Ligoxygakis, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01574 · Cited by 14

Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases

Li, H., Yu, Z., & Zhang, W. (2020) · STEMedicine · doi:10.37175/stemedicine.v1i4.63 · Cited by 14

Pushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression

Raab‐Graham, K. F., Workman, E. R., Namjoshi, S. V., & Niere, F. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.020 · Cited by 13

Fragment-based virtual screening identifies a first-in-class preclinical drug candidate for Huntington’s disease

Galyan, S. M., Ewald, C. Y., Jalencas, X., Masrani, S., Meral, S., Lamottke, K., & Mestres, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-21900-2 · Cited by 13

A common molecular and cellular pathway in developing Alzheimer and cancer

Ali, M., Wani, S. U. D., Dey, T., Sridhar, S. B., & QADRIE, Z. L. (2023) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2023.101625 · Cited by 14

Metformin Lysosomal Targeting: A Novel Aspect to Be Investigated for Metformin Repurposing in Neurodegenerative Diseases?

Papini, N., Giussani, P., & Tringali, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168884 · Cited by 16

Mitochondria at the crossroads: Quality control mechanisms in neuronal senescence and neurodegeneration

Zheng, Y., Yang, J., Li, X., Qi, L., Zheng, Z., Kong, J., Zhang, G., & Guo, Y. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106862 · Cited by 14

Evidence for autophagic gridlock in aging and neurodegeneration

Bakhoum, M. F., Bakhoum, C. Y., Ding, Z., Carlton, S. M., Campbell, G. A., & Jackson, G. R. (2014) · Translational research · doi:10.1016/j.trsl.2014.01.016 · Cited by 13

Key network approach reveals new insight into Alzheimer's disease

Schluesener, J. K., Zhu, X., Schluesener, H. J., Wang, G., & Ao, P. (2014) · IET Systems Biology · doi:10.1049/iet-syb.2013.0047 · Cited by 13

REDD1 Is Involved in Amyloid β-Induced Synaptic Dysfunction and Memory Impairment

Yi, J. H., Kwon, H., Cho, E., Jeon, J., Lee, J., Lee, Y. C., Cho, J. H., Jun, M., Moon, M., Ryu, J. H., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249482 · Cited by 14

Connectivity Map Analysis of a Single-Cell RNA-Sequencing -Derived Transcriptional Signature of mTOR Signaling

Mahi, N. A., Zhang, E. Y., Sherman, S. G., Yu, J. J., & Medvedovic, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094371 · Cited by 13

Improved autophagic flux is correlated with mTOR activation in the later recovery stage of experimental acute pancreatitis

Hu, Y., Zhou, C., Dou, W.-H., Tang, W., Hu, C.-Y., Hu, D., Feng, H., Wang, J.-Z., Qian, M.-J., Cheng, G., et al. (2015) · Pancreatology · doi:10.1016/j.pan.2015.06.004 · Cited by 13

AKT3 Gene Transfer Promotes Anabolic Reprogramming and Photoreceptor Neuroprotection in a Pre-clinical Model of Retinitis Pigmentosa

McDougald, D. S., Papp, T. E., Zezulin, A. U., Zhou, S., & Bennett, J. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.04.009 · Cited by 13

3, 14, 19‐Triacetyl Andrographolide alleviates the cognitive dysfunction of 3 × Tg‐AD mice by inducing initiation and promoting degradation process of autophagy

Zhang, H., Xie, X., Shi, J.-Z., Zhao, Q., Luo, D., Hao, J., Zhou, Y., Han, G., & Pang, X. (2022) · Phytotherapy Research · doi:10.1002/ptr.7619 · Cited by 13

PPAR Gamma Coactivator 1 Beta (PGC-1β) Reduces Mammalian Target of Rapamycin (mTOR) Expression via a SIRT1-Dependent Mechanism in Neurons

Liu, Y., Gao, X., Zhang, Z., Lin, Z., & Zou, Q. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0425-5 · Cited by 13

mTOR : at the crossroads of aging, chaperones, and A lzheimer's disease

Gouras, G. K. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12098 · Cited by 13

Crosstalk between epigenetics and mTOR as a gateway to new insights in pathophysiology and treatment of Alzheimer's disease

Agarwal, D., Kumari, R., Ilyas, A., Tyagi, S., Kumar, R., & Poddar, N. K. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.10.026 · Cited by 12

HEXA-018, a Novel Inducer of Autophagy, Rescues TDP-43 Toxicity in Neuronal Cells

Lee, S., Jo, M., Lee, H., Jeon, Y., Kim, S., Kwon, Y., Woo, J., Han, S., Mun, J. Y., & Kim, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.747975 · Cited by 12

Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes

Levitin, M. O., Rawlins, L. E., Sánchez-Andrade, G., Arshad, O. A., Collins, S. C., Sawiak, S. J., Iffland, P. H., Andersson, M. H. L., Bupp, C. P., Cambridge, E. L., et al. (2023) · Brain · doi:10.1093/brain/awad231 · Cited by 13

A multi‐layered network model identifies Akt1 as a common modulator of neurodegeneration

Na, D., Lim, D., Hong, J., Lee, H., Cho, D., Yu, M., Shaker, B., Ren, J. T., Lee, B., Song, J. G., et al. (2023) · Molecular Systems Biology · doi:10.15252/msb.202311801 · Cited by 14

Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer’s Disease: A Systematic Review and Meta-analysis of Preclinical Studies

Cai, J., Xie, D., Kong, F., Zhai, Z., Zhu, Z., Zhao, Y., Xu, Y., & Sun, T. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231249 · Cited by 13

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer’s disease

Sonsalla, M. M., Babygirija, R., Johnson, M., Cai, Y. S., Cole, M., Yeh, C., Grunow, I., Liu, Y., Vertein, D., Calubag, M. F., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01337-3 · Cited by 14

Genetic Findings in Obsessive–Compulsive Disorder Connect to Brain‐Derived Neurotropic Factor and Mammalian Target of Rapamycin Pathways: Implications for Drug Development

Grados, M. A., Sung, H. M., Kim, S.-J., & Srivastava, S. (2014) · Drug Development Research · doi:10.1002/ddr.21223 · Cited by 11

Rapamycin prevents the long‐term impairing effects of adolescence Δ‐9‐tetrahydrocannabinol on memory and plasticity in male rats

Sabran‐Cohen, T., Bright, U., Zer‐Aviv, T. M., & Akirav, I. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15425 · Cited by 14

Restoration of Sleep and Circadian Behavior by Autophagy Modulation in Huntington's Disease

Sharma, A., Narasimha, K., Manjithaya, R. R., & Sheeba, V. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1894-22.2023 · Cited by 12

Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease

Kim, S., Hyun, D. G., Nam, Y., Shin, S. J., Im, D., Kim, H. S., Leem, S. H., Park, H. H., Kim, B., Park, Y., et al. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115770 · Cited by 13

The protein-interaction network with functional roles in tumorigenesis, neurodegeneration, and aging

Nahálková, J. (2016) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-016-2836-5 · Cited by 13

Brain targeted delivery of rapamycin using transferrin decorated nanostructured lipid carriers

Khonsari, F., Heydari, M., Dinarvand, R., Sharifzadeh, M. S., & Atyabi, F. (2021) · Bioimpacts · doi:10.34172/bi.2021.23389 · Cited by 13

Functional neuroimaging: a physiological perspective

Lin, A. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00017 · Cited by 13

Current aspects of targeting cellular senescence for the therapy of neurodegenerative diseases

Jaganathan, R., Iyaswamy, A., Krishnamoorthi, S., Thakur, A., Durairajan, S. S. K., Yang, C., & Wankhar, D. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1627921 · Cited by 12

mTOR Signaling: Recent Progress

Gargalionis, A. N., Papavassiliou, K. A., & Papavassiliou, A. G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052587 · Cited by 12

mTOR inhibition enhances synaptic and mitochondrial function in Alzheimer’s disease in an APOE genotype-dependent manner

Sanganahalli, B. G., Mihailovic, J. M., Vekaria, H. J., Coman, D., Yackzan, A. T., Flemister, A., Aware, C. B., Wenger, K., Hubbard, W. B., Sullivan, P. G., et al. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241261942 · Cited by 12

Molecular and Cellular Foundations of Aging of the Brain: Anti-aging Strategies in Alzheimer’s Disease

Dziewa, M., Złotek, M., Herbet, M., & Piątkowska‐Chmiel, I. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01514-0 · Cited by 11

Autophagy Dysfunction and Neurodegeneration: Where Does It Go Wrong?

Oettinger, D., & Yamamoto, A. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169219 · Cited by 10

Downregulation of miR-33 Has Protective Effect Against Aβ25–35-Induced Injury in SH-SH-SY5Y Cells

Wang, X.-P., Li, X.-J., Huang, B., Yang, L., Chen, K., Zhao, D., Luo, X., & Wang, Y. (2020) · Medical Science Monitor · doi:10.12659/msm.921026 · Cited by 15

Recent Advances Towards Diagnosis and Therapeutic Fingerprinting for Alzheimer’s Disease

Pradhan, L. K., Sahoo, P. K., Chauhan, S., & Das, S. K. (2022) · Journal of Molecular Neuroscience · doi:10.1007/s12031-022-02009-7 · Cited by 11

Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice

Shahani, N., Huang, W., Varnum, M. M., Page, D. T., & Subramaniam, S. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.11.006 · Cited by 11

Nicotine inhibits rapamycin-induced pain through activating mTORC1/S6K/IRS-1-related feedback inhibition loop

Li, S., Guan, S., Wang, Y., Cheng, L., Yang, Q., Tian, Z., Zhao, M., Wang, X., & Feng, B. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.04.016 · Cited by 11

Biomarkers, interventions and healthy ageing

Kenessary, A., Zhumadilov, Z. S., Nurgozhin, T. S., Kipling, D., Yeoman, M. S., Cox, L. S., Ostler, E. L., & Faragher, R. (2012) · New Biotechnology · doi:10.1016/j.nbt.2012.11.018 · Cited by 11

Role of PIM Kinase Inhibitor in the Treatment of Alzheimer’s Disease

Meur, S., Mukherjee, S., Roy, S., & Karati, D. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04257-7 · Cited by 10

Pharmacokinetic analysis of intermittent rapamycin administration in early-stage Alzheimer's Disease

Wallgren, H. A., Kivipelto, M., Plavén‐Sigray, P., & Svensson, J. E. (2025) · GeroScience · doi:10.1007/s11357-025-01911-3 · Cited by 12

Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy

Streubel-Gallasch, L., Zyśk, M., Beretta, C., & Erlandsson, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-02371-3 · Cited by 11

Epigenetic regulation and autophagy modulation debilitates insulin resistance associated Alzheimer’s disease condition in rats

Kakoty, V., Sarathlal, K. C., Dubey, S. K., Yang, C., Marathe, S. A., & Taliyan, R. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-021-00846-w · Cited by 12

An Update on Autophagy as a Target in the Treatment of Alzheimer’s Disease

Sose, P. M., Doshi, G., & Kale, P. P. (2023) · Current Drug Targets · doi:10.2174/1389450124666230417104325 · Cited by 10

Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model

Yang, D., Zhu, L., Ren, J., Ma, R., Zhu, H., & Xu, J. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1541-9 · Cited by 10

A derangement of the brain wound healing process may cause some cases of Alzheimer's disease.

Lehrer, S. P., & Rheinstein, P. H. (2016) · PubMed · Cited by 10

Beta Amyloid Peptides: Extracellular and Intracellular Mechanisms of Clearance in Alzheimer’s Disease

Hernández-Zimbrón, L. F., Gorostieta-Salas, E., Díaz-Hung, M.-L., Pérez-Garmendia, R., Gevorkian, G., & Quiroz-Mercado, H. (2016) · InTech eBooks · doi:10.5772/64744 · Cited by 10

Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons and the hippocampus of a mouse model of FINCA disease

Hiltunen, A. E., Kangas, S. M., Ohlmeier, S., Pietilä, I., Hiltunen, J., Tanila, H., McKerlie, C., Govindan, S., Tuominen, H. J., Kaarteenaho, R. L., et al. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00245-4 · Cited by 10

Involvement of astrocyte senescence in Alzheimer's disease

Tüzer, F., & Torres, C. A. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102594 · Cited by 10

Deciphering the enigmatic crosstalk between prostate cancer and Alzheimer's disease: A current update on molecular mechanisms and combination therapy

Poddar, N. K., Agarwal, D., Agrawal, Y., Wijayasinghe, Y. S., Mukherjee, A., & Khan, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166524 · Cited by 10

Identifying Disease Signatures in the Spinocerebellar Ataxia Type 1 Mouse Cortex

Luttik, K. P., Olmos, V., Owens, A., Khan, A., Yun, J., Driessen, T. M., & Lim, J. (2022) · Cells · doi:10.3390/cells11172632 · Cited by 9

Unravelling the Alzheimer's pathogenesis: Molecular and cellular pathways to neurodegeneration and therapeutic targets

Chauhan, P., Wadhwa, K., & Singh, G. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156109 · Cited by 12

Autophagy activator AA-20 improves proteostasis and extends Caenorhabditis elegans lifespan

Tan, E. P., Lyang, N., Doroodian, S., Sanz-Martinez, P., Xu, J., Zaretski, S., Nieto-Torres, J. L., Ebata, H., Lim, S. H. Y., Hou, W. C., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2423455122 · Cited by 10

Rethinking neurodegeneration through a co-proteinopathy lens

Zhang, Y. P., Kedia, S., & Klenerman, D. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.10.006 · Cited by 13

Activation of PI3k/Akt/mTOR Signaling Induces Deposition of p-tau to Promote Aluminum Neurotoxicity

Xu, Y., Zhang, G., Zhao, Y., Bu, F., & Zhang, Y. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00573-9 · Cited by 9

Autophagy at the synapse, an early site of dysfunction in neurodegeneration

Jasutkar, H. G., & Yamamoto, A. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2023.100631 · Cited by 9

Exploitation of Autophagy Inducers in the Management of Dementia: A Systematic Review

Corasaniti, M. T., Bagetta, G., Nicotera, P., Maione, S., Tonin, P., Guida, F., & Scuteri, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021264 · Cited by 10

Aging, Metabolism, Synaptic Activity, and Aβ in Alzheimer's Disease

Gouras, G. K. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00185 · Cited by 10

Diabetes influences the fusion of autophagosomes with lysosomes in SH-SY5Y cells and induces Aβ deposition and cognitive dysfunction in STZ-induced diabetic rats

Ma, L., Liu, S., Guo, Y.-G., Ma, Z.-Q., Li, Y., Wang, S., Niu, Y., Li, M., Zhai, J., Shang, S., et al. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114286 · Cited by 9

The impact of proteostasis dysfunction secondary to environmental and genetic causes on neurodegenerative diseases progression and potential therapeutic intervention

Elmatboly, A. M., Sherif, A., Deeb, D. A., Benmelouka, A. Y., Bin-Jumah, M. N., Aleya, L., & Abdel‐Daim, M. M. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-07914-1 · Cited by 9

Dietary and Metabolic Approaches for Treating Autism Spectrum Disorders, Affective Disorders and Cognitive Impairment Comorbid with Epilepsy: A Review of Clinical and Preclinical Evidence

Iyer, S. H., Yeh, M. Y., Netzel, L., Lindsey, M. G., Wallace, M., Simeone, K. A., & Simeone, T. A. (2024) · Nutrients · doi:10.3390/nu16040553 · Cited by 8

Gut microbiota: A new window for the prevention and treatment of neuropsychiatric disease

Tang, Y., Zhang, Y., Chen, C., Cao, Y., Wang, Q., & Tang, C. (2025) · Journal of Central Nervous System Disease · doi:10.1177/11795735251322450 · Cited by 10

Unlocking the therapeutic potential of protein kinase inhibitors in neurodegenerative and psychiatric disorders

Angela Asir, R., V, Buzaeva, P., & Michaelevski, I. (2025) · Exploration of Drug Science · doi:10.37349/eds.2025.100892 · Cited by 8

Ginsenoside Rg1 improves autophagy dysfunction to ameliorate Alzheimer's disease via targeting FGR proto-oncogene

Quan, Q., Ma, X., Feng, J., Li, W., & Li, X. (2025) · Neuropeptides · doi:10.1016/j.npep.2025.102514 · Cited by 9

Autophagy–NAD+ axis: emerging insights into neuronal homeostasis and neurodegenerative diseases

Koçak, G., Dimas, M. M., Silva, L., Silva-Amaral, D., Sun, C., Cruddas, S., Barrett, T. G., Martins‐de‐Souza, D., Cunha‐Neto, E., Brocardo, P. S., et al. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1695486 · Cited by 8

Dietary Impact on Neuronal Autophagy Control and Brain Health

Ntsapi, C., du Toit, A., & Loos, B. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85228 · Cited by 8

Autophagy and Cell Death in Alzheimer’s, Parkinson’s and Prion Diseases

Ribarič, S., & Ribarič, I. M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.86706 · Cited by 9

Modifying Dietary Protein Impacts mTOR Signaling and Brain Deposition of Amyloid β in a Knock-In Mouse Model of Alzheimer Disease

Bensalem, J., Hein, L. K., Hassiotis, S., Trim, P. J., Proud, C. G., Heilbronn, L. K., & Sargeant, T. J. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.02.035 · Cited by 8

Antimicrobial therapy and the potential mechanisms in Alzheimer’s disease

Song, X., Chen, J., Hou, Z., & Xie, N. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135464 · Cited by 8

Potential mechanisms underlying lithium treatment for Alzheimer's disease and COVID-19.

Wei, H.-F., Anchipolovsky, S., Vera, R., Liang, G., & Chuang, D. M. (2022) · PubMed · doi:10.26355/eurrev_202203_28369 · Cited by 8

Protein kinase inhibitors as therapeutics in neurodegenerative and psychiatric disorders

Tridente, G., Jana, A., Nath, A., & Ashraf, G. M. (2023) · Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders · doi:10.1016/b978-0-443-18677-6.00015-4 · Cited by 8

The mTOR Signaling Pathway in Neurodegenerative Diseases

Francois, A., Vérité, J., Bilan, A. R., Janet, T., Calon, F., Fauconneau, B., Paccalin, M., & Page, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00011-6 · Cited by 8

A Therapeutic Target for Inhibition of Neurodegeneration: Autophagy

Pupyshev, A. B., Короленко, Т. А., & Tikhonova, M. A. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0519-7 · Cited by 8

Yishen Huazhuo Decoction Induces Autophagy to Promote the Clearance of Aβ1-42 in SAMP8 Mice: Mechanism Research of a Traditional Chinese Formula Against Alzheimer’s Disease

Wang, K., Sun, W., Xu, J., Qijing, Q., Yu, Z., Cheng, R., Zhang, L., Liu, S., Zhou, Z., Zhang, Y., et al. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319666200604174223 · Cited by 7

Physostigmine Restores Impaired Autophagy in the Rat Hippocampus after Surgery Stress and LPS Treatment

von Haefen, C., Sifringer, M., Endesfelder, S., Kalb, A., González-López, A., Tegethoff, A., Paeschke, N., & Spies, C. (2018) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-018-9790-9 · Cited by 8

Rapamycin Joins the Aging Fray: Maybe Ponce de Leon Visited Rapa Nui, not Florida

Sierra, F. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq049 · Cited by 8

Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects of Euterpe oleracea Mart. (Açaí) in Improving Cognition Deficits: Potential Therapeutic Implications for Alzheimer’s Disease

Ferreira, F. D. S., de Mattos, J. L. A., da Silva, P. H. F., da Costa, C. A., Ognibene, D. T., Resende, Â. C., & de Bem, G. F. (2025) · Plants · doi:10.3390/plants14132010 · Cited by 7

Repurposing oncology drugs for Alzheimer’s: multi-omic convergence targeting cell-cycle, proteostasis, immunometabolism, and senescence

Gopukumar, S. T., Dwivedi, D., Gowri, K., Karpakavalli, M., Nair, C., Singh, D., & Das, U. (2025) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2025.100237 · Cited by 11

Gamma Frequency Inhibits the Secretion and Aggregation of Amyloid-β and Decreases the Phosphorylation of mTOR and Tau Proteins in vitro

Yang, Y.-H., Hsieh, S., Chang, H., Sung, J.-L., Chuu, C., Yen, C., & Hour, T. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220307 · Cited by 8

Autophagy as a Promising Therapeutic Target in Age-Associated Neurodegenerative Disorders

Bhaduri, I., Trisal, A., & Singh, A. K. (2023) · Springer eBooks · doi:10.1007/978-981-19-7443-4_3 · Cited by 7

Rapamycin and mTOR inhibitors probably have therapeutic effects for post-operative cognitive dysfunction

Yang, C., Zhu, B., Shen, J., Hu, T., Li, Z., & Hong, T. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.06.017 · Cited by 7

Altered Cholesterol Intracellular Trafficking and the Development of Pathological Hallmarks of Sporadic AD

Chen, X., Liang, H., Soliman, M. L., & Geiger, J. D. (2014) · Journal of Parkinson’s Disease and Alzheimer’s Disease · doi:10.13188/2376-922x.1000002 · Cited by 7

3-methyladenine, an autophagic inhibitor, attenuates therapeutic effects of sirolimus on scopolamine-induced cognitive dysfunction in a rat model.

Zhu, B., Yang, C., Ding, L., & Liu, N. (2014) · PubMed Central · Cited by 7

Cell type specific contributions of mTOR inhibition that drive neuroprotective mechanisms in Alzheimer’s disease

Haynes, K. A., dos Santos, D. F. D. S., Williams, S. G., Hart, J. T., Lehman, A. M., Eckels, S. E., Nepali, U., Reddy, A., Finkel, T., & Rizzo, S. J. S. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.092635

O4‐07‐05: The role of mTOR in Alzheimer's disease: Lessons from animal models

Oddo, S. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1675

P3‐151: mTOR regulates chaperone networks and cognitive outcomes in mice modeling Alzheimer's disease

Pierce, A. P., Podlutskaya, N., & Galván, V. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.1591

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.

Tramutola, A., Lanzillotta, C., & Di Domenico, F. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1244482 · Cited by 69