Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Developments of a water-maze procedure for studying spatial learning in the rat

Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.

Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Bjørkøy, G., Lamark, T., Brech, A., Outzen, H., Perander, M., Øvervatn, A., Stenmark, H., & Johansen, T. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200507002 · Cited by 3,276

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Sarbassov, D. D., Ali, S. M., Sengupta, S., Sheen, J.-H., Hsu, P. P., Bagley, A. F., Markhard, A. L., & Sabatini, D. M. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.029 · Cited by 2,365

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature · doi:10.1038/369756a0 · Cited by 2,053

FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

Mammucari, C., Milan, G., Romanello, V., Masiero, E., Rudolf, R., Del Piccolo, P., Burden, S. J., Di Lisi, R., Sandri, C., Zhao, J., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.001 · Cited by 1,953

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892

Gintonin stimulates autophagic flux in primary cortical astrocytes

Rahman, M. A., Hwang, H., Nah, S.-Y., & Rhim, H. (2018) · Journal of Ginseng Research · doi:10.1016/j.jgr.2018.08.004 · Cited by 35

Pharmacological Interventions to Attenuate Alzheimer’s Disease Progression: The Story So Far

Bazzari, F. H., Abdallah, D. M., & El-Abhar, H. S. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666190301111120 · Cited by 39

Activate or Inhibit? Implications of Autophagy Modulation as a Therapeutic Strategy for Alzheimer’s Disease

Krishnan, S., Shrestha, Y., Jayatunga, D. P. W., Rea, S. L., Martins, R. N., & Bharadwaj, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186739 · Cited by 38

Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model

Pupyshev, A. B., Беличенко, В. М., Tenditnik, M. V., Bashirzade, A. A., Dubrovina, N. I., Ovsyukova, M. V., Akopyan, A. A., Fedoseeva, L. A., Короленко, Т. А., Amstislavskaya, T. G., et al. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173406 · Cited by 38

Neuroprotection in metabolism-based therapy

Hartman, A. L. (2011) · Epilepsy Research · doi:10.1016/j.eplepsyres.2011.04.016 · Cited by 39

mTOR-dependent TFEB activation and TFEB overexpression enhance autophagy-lysosome pathway and ameliorate Alzheimer's disease-like pathology in diabetic encephalopathy

Cheng, L., Chen, Y., Guo, D., Zhong, Y., Li, W., Lin, Y., & Miao, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01097-1 · Cited by 37

Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells

Lee, H. R., Shin, H. K., Park, S. Y., Kim, H. Y., Bae, S. S., Lee, W. S., Rhim, B. Y., Hong, K. W., & Kim, C. D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134486 · Cited by 36

Beneficial Role of Rapamycin in Experimental Autoimmune Myositis

Prevel, N., Allenbach, Y., Klatzmann, D., Salomon, B. L., & Benvéniste, O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074450 · Cited by 40

FASTKD2 is associated with memory and hippocampal structure in older adults

Ramanan, V. K., Nho, K. T., Shen, L., Risacher, S. L., Kim, S., McDonald, B. C., Farlow, M. R., Foroud, T., Gao, S., Soininen, H. S., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.142 · Cited by 37

Neuritin can normalize neural deficits of Alzheimer’s disease

An, K., Jung, J. H., Jeong, A. Y., Kim, H. G., Jung, S., Lee, K., Kim, H. J., Kim, S.-J., Jeong, T.-Y., Son, Y., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.478 · Cited by 35

Methyllycaconitine Alleviates Amyloid-β Peptides-Induced Cytotoxicity in SH-SY5Y Cells

Zheng, X., Xie, Z., Zhu, Z., Liu, Z., Wang, Y., Wei, L., Yang, H., Yang, H., Liu, Y., & Bi, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111536 · Cited by 36

A genetic screen identifies Tor as an interactor of VAPB in a Drosophila model of amyotrophic lateral sclerosis

Deivasigamani, S., Verma, H., Ueda, R., Ratnaparkhi, A., & Ratnaparkhi, G. S. (2014) · Biology Open · doi:10.1242/bio.201410066 · Cited by 33

Defective Autophagy and Mitophagy in Alzheimer’s Disease: Mechanisms and Translational Implications

Chen, J., He, H., Ye, Q., Feng, F., Wang, W., Gu, Y., Han, R., & Xie, C. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02487-7 · Cited by 37

A nexus of miR-1271, PAX4 and ALK/RYK influences the cytoskeletal architectures in Alzheimer's Disease and Type 2 Diabetes

Majumder, P., Chanda, K., Das, D., Singh, B. K., Chakrabarti, P., Jana, N. R., & Mukhopadhyay, D. (2021) · Biochemical Journal · doi:10.1042/bcj20210175 · Cited by 38

Selenium-enriched yeast inhibited β-amyloid production and modulated autophagy in a triple transgenic mouse model of Alzheimer's disease

Song, G.-L., Chen, C., Wu, Q., Zhang, Z.-H., Zheng, R., Chen, Y., Jia, S.-Z., & Ni, J. (2018) · Metallomics · doi:10.1039/c8mt00041g · Cited by 38

Role and treatment of mitochondrial DNA-related mitochondrial dysfunction in sporadic neurodegenerative diseases

H. Swerdlow, R. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211798072535 · Cited by 35

Potential Clinical Implications of Senotherapies for Cardiovascular Disease

Suda, M., Katsuumi, G., Tchkonia, T., Kirkland, J. L., & Minamino, T. (2023) · Circulation Journal · doi:10.1253/circj.cj-23-0657 · Cited by 37

Genome-Wide Analysis of miRNA Signature in the APPswe/PS1ΔE9 Mouse Model of Alzheimer's Disease

Luo, H., Wu, Q., Ye, X., Xiong, Y., Zhu, J., Xu, J., Diao, Y., Zhang, D., Wang, M., JinHua, Q., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101725 · Cited by 35

Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues.

Bayod, S., del Valle, J., Pelegrı́, C., Vilaplana, J., Canudas, A. M., Camins, A., Jiménez, A., Sanchez‐Roige, S., Lalanza, J. F., Escorihuela, R. M., et al. (2014) · PubMed · Cited by 35

The Cutting Edge: The Role of mTOR Signaling in Laminopathies

Chiarini, F., Evangelisti, C., Cenni, V., Fazio, A., Paganelli, F., Martelli, A. M., & Lattanzi, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040847 · Cited by 36

Endolysosome and Autolysosome Dysfunction in Alzheimer’s Disease: Where Intracellular and Extracellular Meet

van Weering, J. R. T., & Scheper, W. (2019) · CNS Drugs · doi:10.1007/s40263-019-00643-1 · Cited by 38

Compounds that extend longevity are protective in neurodegenerative diseases and provide a novel treatment strategy for these devastating disorders

Soo, S. K., Rudich, P. D., Traa, A., Harris-Gauthier, N., Shields, H. J., & Raamsdonk, J. M. V. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111297 · Cited by 37

Lithium and the Interplay Between Telomeres and Mitochondria in Bipolar Disorder

Lundberg, M., Millischer, V., Backlund, L., Martinsson, L., Stenvinkel, P., Sellgren, C. M., Lavebratt, C., & Schalling, M. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.586083 · Cited by 38

Role of Herbal Teas in Regulating Cellular Homeostasis and Autophagy and Their Implications in Regulating Overall Health

Brimson, J. M., Prasanth, M. I., Malar, D. S., Sharika, R., Sivamaruthi, B. S., Kesika, P., Chaiyasut, C., Tencomnao, T., & Prasansuklab, A. (2021) · Nutrients · doi:10.3390/nu13072162 · Cited by 38

Astrocytes in Down Syndrome Across the Lifespan

Ponroy Bally, B., & Murai, K. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.702685 · Cited by 35

Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways

Song, G., LI, Y., Lin, L., & Cao, Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4382 · Cited by 37

Rapamycin for longevity: the pros, the cons, and future perspectives

Roark, K. M., & Iffland, P. H. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1628187 · Cited by 37

Genetics and Pharmacology of Longevity

Castillo-Quan, J. I., Kinghorn, K. J., & Bjedov, I. (2015) · Advances in genetics · doi:10.1016/bs.adgen.2015.06.002 · Cited by 37

Aging and TOR: interwoven in the fabric of life

Sharp, Z. D. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0542-0 · Cited by 35

Protein recycling pathways in neurodegenerative diseases

Fecto, F., Esengul, Y. T., & Siddique, T. (2014) · Alzheimer s Research & Therapy · doi:10.1186/alzrt243 · Cited by 34

Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease

Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2018) · BioMed Research International · doi:10.1155/2018/1483791 · Cited by 36

Intranasal insulin activates Akt2 signaling pathway in the hippocampus of wild-type but not in APP/PS1 Alzheimer model mice

Gabbouj, S., Natunen, T., Koivisto, H., Jokivarsi, K. T., Takalo, M., Marttinen, M., Wittrahm, R., Kemppainen, S., Naderi, R., Posado-Fernández, A., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.11.008 · Cited by 37

Periodic dietary restriction ameliorates amyloid pathology and cognitive impairment in PDAPP-J20 mice: Potential implication of glial autophagy

Gregosa, A., Vinuesa, Á., Todero, M. F., Pomilio, C. J., Rossi, S. P., Bentivegna, M., Presa, J., Wenker, S. D., Saravia, F., & Beauquis, J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104542 · Cited by 34

DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling

Bai, X., Wu, J., Zhang, M., Xu, Y., Duan, L., Yao, K., Zhang, J., Bo, J., Zhao, Y., Xu, G., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.513605 · Cited by 33

Research Progress on Mechanism of Neuroprotective Roles of Apelin-13 in Prevention and Treatment of Alzheimer’s Disease

Wan, T., Fu, M., Jiang, Y., Jiang, W., Li, P., & Zhou, S. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03448-1 · Cited by 38

Neurons die with heightened but functional macro- and chaperone mediated autophagy upon increased amyloid-ß induced toxicity with region-specific protection in prolonged intermittent fasting

Ntsapi, C., & Loos, B. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112840 · Cited by 35

Chronic oral rapamycin decreases adiposity, hepatic triglycerides and insulin resistance in male mice fed a diet high in sucrose and saturated fat

den Hartigh, L. J., Goodspeed, L., Wang, S. A., Kenerson, H. L., Omer, M., O’Brien, K. D., Ladiges, W., Yeung, R. S. W., & Subramanian, S. (2018) · Experimental Physiology · doi:10.1113/ep087207 · Cited by 33

Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons

Shen, W., Henry, A. G., Paumier, K. L., Li, L., Mou, K., Dunlop, J., Berger, Z., & Hirst, W. D. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12672 · Cited by 36

Rapamycin, anti-aging, and avoiding the fate of Tithonus

Richardson, A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70800 · Cited by 35

Use of Zebrafish Genetic Models to Study Etiology of the Amyloid-Beta and Neurofibrillary Tangle Pathways in Alzheimer's Disease

Freeman, J. L., & Kiper, K. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210524155944 · Cited by 33

‘Click’ assembly of glycoclusters and discovery of a trehalose analogue that retards Aβ40 aggregation and inhibits Aβ40-induced neurotoxicity

Rajaram, H., Palanivelu, M. K., Arumugam, T. V., Rao, V. M., Shaw, P. N., McGeary, R. P., & Ross, B. P. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.07.077 · Cited by 32

Molecular Targets in Alzheimer’s Disease: From Pathogenesis to Therapeutics

Cheng, X., Zhang, L., & Lian, Y. (2015) · BioMed Research International · doi:10.1155/2015/760758 · Cited by 36

Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer’s and Parkinson’s disease models of neurodegeneration

Griffin, E. F., Yan, X., Caldwell, K. A., & Caldwell, G. A. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy308 · Cited by 34

Pharmacological Tools to Modulate Autophagy in Neurodegenerative Diseases

Suresh, S., Chakravorty, A., Giridharan, M., Garimella, L., & Manjithaya, R. R. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.02.023 · Cited by 34

Everolimus improves memory and learning while worsening depressive- and anxiety-like behavior in an animal model of depression.

Russo, E., Leo, A., Crupi, R., Aiello, R., Lippiello, P., Spiga, R., Chimirri, S., Citraro, R., Cuzzocrea, S., Constanti, A., et al. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.03.008 · Cited by 29

Autophagy and Alzheimer’s Disease: Mechanisms and Impact Beyond the Brain

Hein, Z. M., Vishnumukkala, T., Karikalan, B., Alkatiri, A., Hussan, F., Jagadeesan, S., Kamaruzzaman, M. A., Ramli, M. D. C., Nassir, C. M. N. C. M., & Gopalakrishna, P. K. (2025) · Cells · doi:10.3390/cells14120911 · Cited by 37

Age-related increase of VGF-expression in T lymphocytes

Busse, S., Steiner, J. H., Micheel, J., Dobrowolny, H., Mawrin, C., Krause, T. J., Adamaszek, M., Bogerts, B., Bommhardt, U., Hartig, R., et al. (2014) · Aging · doi:10.18632/aging.100656 · Cited by 30

G‐ CSF and cognitive dysfunction in elderly diabetic mice with cerebral small vessel disease: Preventive intervention effects and underlying mechanisms

Guan, Z., Tao, Y., Zhang, X., Guo, Q., Liu, Y., Zhang, Y., Wang, Y., Ji, G., Wu, G., Wang, N., et al. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12691 · Cited by 30

Autophagy and lysosomal pathways in nervous system disorders

Bingol, B. (2018) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2018.04.009 · Cited by 32

Withaferin-A Treatment Alleviates TAR DNA-Binding Protein-43 Pathology and Improves Cognitive Function in a Mouse Model of FTLD

Kumar, S., Phaneuf, D., & Julien, J. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00952-0 · Cited by 32

Autophagy in ageing and ageing-related neurodegenerative diseases

Karabiyik, C., Frake, R. A., Park, S. J., Tanasa, M. P., & Rubinsztein, D. C. (2021) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2021.05 · Cited by 31

Protein farnesylation is upregulated in Alzheimer’s human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer’s model mice

Jeong, A., Cheng, S., Zhong, R., Bennett, D. A., Bergö, M. O., & Li, L. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01231-5 · Cited by 31

Therapeutic modulation of JAK-STAT, mTOR, and PPAR-γ signaling in neurological dysfunctions

Kumar, S., Mehan, S., & Narula, A. S. (2022) · Journal of Molecular Medicine · doi:10.1007/s00109-022-02272-6 · Cited by 33

Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs

Santini, E., & Klann, E. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00076 · Cited by 34

Inositol Hexakisphosphate Kinases Induce Cell Death in Huntington Disease

Nagata, E., Saiardi, A., Tsukamoto, H., Okada, Y., Itoh, Y., Satoh, T., Itoh, J., Margolis, R. L., Takizawa, S., Sawa, A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.220749 · Cited by 33

Lamotrigine Reduces β-Site AβPP-Cleaving Enzyme 1 Protein Levels Through Induction of Autophagy

Wu, H., Lu, M., Wang, W., Zhang, M., Zhu, Q.-Q., Xia, Y., Xu, R., Yang, Y., Chen, L., & Ma, Q. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-143162 · Cited by 31

On the relevance of precision autophagy flux control in vivo – Points of departure for clinical translation

Loos, B., Klionsky, D. J., du Toit, A., & Hofmeyr, J. S. (2019) · Autophagy · doi:10.1080/15548627.2019.1687211 · Cited by 32

A new method to measure autophagy flux in the nervous system

Matus, S., Valenzuela, V., & Hetz, C. (2014) · Autophagy · doi:10.4161/auto.28434 · Cited by 29

TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1

Heo, H., Park, H., Lee, M., Kim, J., Kim, J., Jung, S.-Y., Kim, S. K., Lee, S., & Chang, J. (2023) · Autophagy · doi:10.1080/15548627.2023.2287925 · Cited by 31

Heavy metal-induced disruption of the autophagy-lysosomal pathway: implications for aging and neurodegenerative disorders

Das, S., Murumulla, L., Ghosh, P., & Challa, S. (2025) · BioMetals · doi:10.1007/s10534-025-00665-x · Cited by 30

Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis

Cho, I., Jackson, M. R., & Swift, J. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0439-6 · Cited by 32

Novel therapeutic approaches to target neurodegeneration

de la Fuente, A. G., Pelucchi, S., Mertens, J., Luca, M. D., Mauceri, D., & Marcello, E. E. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16078 · Cited by 32

Modulation of amyloid precursor protein expression reduces β‐amyloid deposition in a mouse model

Asuni, A. A., Guridi, M., Pankiewicz, J. E., Sanchez, S., & Sadowski, M. J. (2014) · Annals of Neurology · doi:10.1002/ana.24149 · Cited by 28

Overexpression of let-7a increases neurotoxicity in a PC12 cell model of Alzheimer's disease via regulating autophagy

Gu, H., Li, L., Cui, C., Zhao, Z., & Song, G. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4977 · Cited by 28

Biomedical Implications of Autophagy in Macromolecule Storage Disorders

Palhegyi, A. M., Seranova, E., Dimova, S., Hoque, S., & Sarkar, S. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00179 · Cited by 30

Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice

Xue, T., Yan, M., Wang, L., Zhou, Y., Wang, Z., Xia, T., Liu, X., Pan, R., & Chang, Q. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.57 · Cited by 32

mTOR signalling: jack-of-all-trades

Hiani, Y. E., Egom, E. E. A., & Dong, X. (2018) · Biochemistry and Cell Biology · doi:10.1139/bcb-2018-0004 · Cited by 30

Evidence Linking Protein Misfolding to Quality Control in Progressive Neurodegenerative Diseases

Kabir, M. T., Uddin, M. S., Abdeen, A., Ashraf, G. M., Perveen, A., Hafeez, A., Bin-Jumah, M. N., & Abdel‐Daim, M. M. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200618114924 · Cited by 29

Brain insulin resistance linked Alzheimer’s and Parkinson’s disease pathology: An undying implication of epigenetic and autophagy modulation

Kakoty, V., Sarathlal, K. C., Kumari, S., Yang, C., Dubey, S. K., Sahebkar, A., Kesharwani, P., & Taliyan, R. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01187-z · Cited by 30

Comparative analysis of autophagy and tauopathy related markers in cerebral ischemia and Alzheimer’s disease animal models

Villamil-Ortiz, J., & Cardona-Gómez, G. P. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00084 · Cited by 29

Alteration of Aging‐Dependent Micro RNA s in Idiopathic Pulmonary Fibrosis

Nho, R. S. (2015) · Drug Development Research · doi:10.1002/ddr.21272 · Cited by 27

HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway

Zhu, T., Zhao, D., Song, Z., Yuan, Z., Li, C., Wang, Y., Zhou, X., Yin, X., Hassan, M. F., & Yang, L. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.09.021 · Cited by 29

Targeting PRAS40 for multiple diseases

Chong, Z. Z. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.04.005 · Cited by 28

Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration

Ryan, K. C., Ashkavand, Z., Sarasija, S., Laboy, J. T., Samarakoon, R., & Norman, K. R. (2021) · Aging Cell · doi:10.1111/acel.13472 · Cited by 27

High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4

Khamrui, S., Ung, P. M. U., Secor, C., Schlessinger, A., & Lazarus, M. B. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10458 · Cited by 28

Mitochondrial mechanisms in Alzheimer’s disease: Quest for therapeutics

Kalani, K., Chaturvedi, P., Chaturvedi, P., Verma, V. K., Lal, N., Awasthi, S. K., & Kalani, A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103547 · Cited by 28

Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice

Li, X., Zhang, H., Liu, Y., Dong, X., Han, Y., Su, Y., Li, W., & Li, W. (2023) · Behavioral and Brain Functions · doi:10.1186/s12993-023-00209-8 · Cited by 28

Pharmacological Treatment of Alzheimer’s Disease: Insights from Drosophila melanogaster

Cheng, X., Song, C., Du, Y., Gaur, U., & Yang, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134621 · Cited by 28

Activating autophagy to eliminate toxic protein aggregates with small molecules in neurodegenerative diseases

Fu, Y., Zhang, J., Qin, R., Ren, Y., Zhou, T., Han, B., & Liu, B. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100053 · Cited by 29

Chronic administration of theobromine inhibits mTOR signal in rats

Sugimoto, N., Katakura, M., Matsuzaki, K., Sumiyoshi, E., Yachie, A., & Shido, O. (2018) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13175 · Cited by 26

Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells

Liang, J., Zhou, F., Xiong, X., Zhang, X., Li, S., Li, X., Gao, M., & Yu, W. H. (2019) · Aging · doi:10.18632/aging.102235 · Cited by 27

Signalling Pathways Implicated in Alzheimer′s Disease Neurodegeneration in Individuals with and without Down Syndrome

Martínez‐Cué, C., & Rueda, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186906 · Cited by 26

Endogenous Mechanisms of Neuroprotection: To Boost or Not to Be

Marmolejo-Martínez-Artesero, S., Casas, C., & Romeo-Guitart, D. (2021) · Cells · doi:10.3390/cells10020370 · Cited by 28

Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions

Magalhães, J. D., Fão, L., Vilaça, R., Cardoso, S. M., & Rego, A. C. (2021) · Biomedicines · doi:10.3390/biomedicines9111625 · Cited by 29

Aging and cancer: can mTOR inhibitors kill two birds with one drug?

Sharp, Z. D., & Richardson, A. G. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0168-7 · Cited by 27

Ligands for FKBP12 Increase Ca2+ Influx and Protein Synthesis to Improve Skeletal Muscle Function

Lee, C. S., Georgiou, D. K., Dagnino-Acosta, A., Xu, J., Ismailov, I. I., Knoblauch, M. A., Monroe, T. O., Ji, R., Hanna, A. D., Joshi, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.586289 · Cited by 27

Mathematical Modelling of Metabolic Regulation in Aging

Auley, M. T. M., Mooney, K., Angell, P. J., & Wilkinson, S. J. (2015) · Metabolites · doi:10.3390/metabo5020232 · Cited by 28

Brain metabolism as a modulator of autophagy in neurodegeneration

Lim, Y., Cho, H., & Kim, E. K. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.049 · Cited by 27

Rapamycin-induced autophagy activity promotes bone fracture healing in rats

Yang, G., Duan, X., Lin, D., LI, T., Luo, D., Wang, L., & Lian, K. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2660 · Cited by 27

Experimental modeling of Alzheimer's disease: Translational lessons from cross‐taxon analyses

Yenkoyan, K. B., Kotova, M. M., Apukhtin, K. V., Galstyan, D. S., Amstislavskaya, T. G., Strekalova, T. V., de Abreu, M. S., Chavushyan, V. A., Lim, L. W., Yang, L., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70273 · Cited by 30

Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats

Xue, Q., Yang, H., Li, H.-F., Abadir, P. M., Burks, T. N., Koch, L. G., Britton, S. L., Carlson, J., Chen, L., Walston, J. D., et al. (2016) · Aging · doi:10.18632/aging.100929 · Cited by 27

The Molecular Mechanism of Glucagon-Like Peptide-1 Therapy in Alzheimer’s Disease, Based on a Mechanistic Target of Rapamycin Pathway

Lin, L. (2017) · CNS Drugs · doi:10.1007/s40263-017-0431-2 · Cited by 27

mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model

Polchi, A., Magini, A., Meo, D. D., Tancini, B., & Emiliani, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051474 · Cited by 29

Molecular interplay between hyperactive mammalian target of rapamycin signaling and Alzheimer’s disease neuropathology in the NS-Pten knockout mouse model

Hodges, S. L., Reynolds, C. D., Smith, G. D., Jefferson, T. S., Nolan, S. O., & Lugo, J. N. (2018) · Neuroreport · doi:10.1097/wnr.0000000000001081 · Cited by 26

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases

McAlary, L., Plotkin, S. S., & Cashman, N. R. (2019) · CNS Drugs · doi:10.1007/s40263-019-00657-9 · Cited by 26

Reduction of NgR in perforant path decreases amyloid-β peptide production and ameliorates synaptic and cognitive deficits in APP/PS1 mice

Jiang, R., Wu, X., Wang, B., Guan, R.-X., Lv, L., Li, A.-P., Lei, L., Ma, Y., Li, N., Li, Q., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00616-3 · Cited by 26

From Seeds to Fibrils and Back: Fragmentation as an Overlooked Step in the Propagation of Prions and Prion-Like Proteins

Marrero-Winkens, C., Sankaran, C., & Schätzl, H. M. (2020) · Biomolecules · doi:10.3390/biom10091305 · Cited by 26

Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions

Martins, W. K., Silva, M. N., Pandey, K. R., Maejima, I., Ramalho, E. D. S., Olivon, V. C., Diniz, S. N., & Grasso, D. (2021) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2021.100033 · Cited by 27

Cell Cycle Inhibition without Disruption of Neurogenesis Is a Strategy for Treatment of Aberrant Cell Cycle Diseases: An Update

Liu, D., & Ander, B. P. (2012) · The Scientific World JOURNAL · doi:10.1100/2012/491737 · Cited by 26

Cell type specific contributions of mTOR inhibition that drive neuroprotective mechanisms in Alzheimer’s disease

Haynes, K. A., dos Santos, D. F. D. S., Williams, S. G., Hart, J. T., Lehman, A. M., Eckels, S. E., Nepali, U., Reddy, A., Finkel, T., & Rizzo, S. J. S. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.092635

O4‐07‐05: The role of mTOR in Alzheimer's disease: Lessons from animal models

Oddo, S. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.1675

P3‐151: mTOR regulates chaperone networks and cognitive outcomes in mice modeling Alzheimer's disease

Pierce, A. P., Podlutskaya, N., & Galván, V. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.1591

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

Caccamo, A., Majumder, S., Richardson, A., Strong, R., & Oddo, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.100420 · Cited by 881

Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies.

Tramutola, A., Lanzillotta, C., & Di Domenico, F. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1244482 · Cited by 69