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Involvement of NRF2 in Perfluorooctanoic Acid-Induced Testicular Damage in Male Mice1

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Effects of an Environmentally Relevant PFAS Mixture on Dopamine and Steroid Hormone Levels in Exposed Mice

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Perfluorooctane Sulfonate (PFOS) Exposure Could Modify the Dopaminergic System in Several Limbic Brain Regions

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Perfluorooctane sulfonate exposure causes gonadal developmental toxicity in Caenorhabditis elegans through ROS-induced DNA damage

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Nrf2 Signaling Elicits a Neuroprotective Role Against PFOS-mediated Oxidative Damage and Apoptosis

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PFOS Disturbs BDNF-ERK-CREB Signalling in Association with Increased MicroRNA-22 in SH-SY5Y Cells

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More Signs of Neurotoxicity of Surfactants and Flame Retardants - Neonatal PFOS and PBDE 99 Cause Transcriptional Alterations in Cholinergic Genes in the Mouse CNS

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Developmental Perfluorooctanesulfonic acid (PFOS) exposure as a potential risk factor for late-onset Alzheimer’s disease in CD-1 mice and SH-SY5Y cells

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ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells

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PFHxS induces apoptosis of neuronal cells via ERK1/2-mediated pathway

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Perfluorooctane sulfonate mediates secretion of IL-1β through PI3K/AKT NF-кB pathway in astrocytes

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Connexin 43 mediates PFOS-induced apoptosis in astrocytes

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Involvement of mitogen‐activated protein kinase and NF‐κB signaling pathways in perfluorooctane sulfonic acid‐induced inflammatory reaction in BV2 microglial cells

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PFOS-induced apoptosis through mitochondrion-dependent pathway in human–hamster hybrid cells

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Possible role of serotonin and neuropeptide Y on the disruption of the reproductive axis activity by perfluorooctane sulfonate

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Postnatal exposure to PFOS, but not PBDE 99, disturb dopaminergic gene transcription in the mouse CNS

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Glioma is associated with exposure to legacy and alternative per- and polyfluoroalkyl substances

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Effects of subchronic exposure of perfluorooctane sulfonate on cognitive function of mice and its mechanism

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Perfluorooctane Sulfonate Induces Neuronal Vulnerability by Decreasing GluR2 Expression

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Integrative omics analyses uncover the mechanism underlying the immunotoxicity of perfluorooctanesulfonate in human lymphocytes

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Embryonic exposure to PFAS causes long-term, compound-specific behavioral alterations in zebrafish

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Prenatal exposure to per- and polyfluoroalkyl substances, fetal thyroid function, and intelligence quotient at 7 years of age: Findings from the Sheyang Mini Birth Cohort Study

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N-acetyl cysteine abates hepatorenal toxicities induced by perfluorooctanoic acid exposure in male rats

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Perfluorooctanesulfonic acid exposure altered hypothalamic metabolism and disturbed male fecundity

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Proteomic analysis of perfluorooctane sulfonate‐induced apoptosis in human hepatic cells using the iTRAQ technique

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Perfluoroalkyl acids potentiate glutamate excitotoxicity in rat cerebellar granule neurons

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Extensive literature search and provision of summaries of studies related to the oral toxicity of perfluoroalkylated substances (PFASs), their precursors and potential replacements in experimental animals and humans. Area 1: Data on toxicokinetics (absorption, distribution, metabolism, excretion) in in vitro studies, experimental animals and humans. Area 2: Data on toxicity in experimental animals. Area 3: Data on observations in humans

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Developing integrated PBPK/PD coupled mechanistic pathway model (miRNA-BDNF): An approach towards system toxicology

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Simvastatin inhibits the apoptosis of hippocampal cells in a mouse model of Alzheimer's disease

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Initial study on the possible mechanisms involved in the effects of high doses of perfluorooctane sulfonate (PFOS) on prolactin secretion

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Developmental perfluorooctane sulfonate exposure inhibits long-term potentiation by affecting AMPA receptor trafficking

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Perfluorooctane sulfonate induces apoptosis of hippocampal neurons in rat offspring associated with calcium overload

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Association between dietary exposure to chemical contaminants and risk of dementia in older persons

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The role of per‐ and polyfluoroalkyl substances in cognitive impairment and dementia

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Inhalation of air polluted with gasoline vapours alters the levels of amino acid neurotransmitters in the cerebral cortex, hippocampus, and hypothalamus of the rat

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The association between maternal perfluoroalkyl substances exposure and early attention deficit hyperactivity disorder in children: a systematic review and meta-analysis

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[Corrigendum] Simvastatin inhibits the apoptosis of hippocampal cells in a mouse model of Alzheimer's disease

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Perinatal exposure to PFOS and sustained high-fat diet promote neurodevelopmental disorders via genomic reprogramming of pathways associated with neuromotor development

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Exploring the neurodegenerative potential of per- and polyfluoroalkyl substances through an adverse outcome pathway network

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Interaction between Per- and Polyfluorinated Substances (PFAS) and Acetaminophen in Disease Exacerbation—Focusing on Autism and the Gut–Liver–Brain Axis

Jiang, D. Q. Y., & Guo, T. L. (2024) · Toxics · doi:10.3390/toxics12010039 · Cited by 13

Effects of perfluorooctane sulfonate (PFOS) on cognitive behavior and autophagy of male mice

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Per- and polyfluoroalkyl substances (PFAS), perceived stress, and depressive symptoms in a prospective cohort study of black women

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The impact of early life exposure to individual and combined PFAS on learning, memory, and bioaccumulation in C. elegans

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Mitochondrial and inflammatory dysfunctions underlie perfluorooctane sulfonic acid (PFOS)-induced neurotoxicity in adult zebrafish

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Identification of the mechanisms underlying per- and polyfluoroalkyl substance-induced hippocampal neurotoxicity as determined by network pharmacology and molecular docking analyses

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Perfluorooctane sulfonate induces apoptosis via activation of FoxO3a and upregulation of proapoptotic Bcl-2 proteins in PC12 cells

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Persistent organic pollutants: Neurotoxic mechanisms and insights from organoid models

Ji, Z., Chen, L., & Ming, D. (2026) · Toxicology · doi:10.1016/j.tox.2026.154408 · Cited by 5

Perfluorooctane Sulfonate (PFOS) Negatively Impacts Prey Capture Capabilities in Larval Zebrafish

Zoodsma, J. D., Boonkanon, C., Running, L. S., Basharat, R., Atilla‐Gokcumen, G. E., Aga, D. S., & Sirotkin, H. I. (2023) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5819 · Cited by 5

Neurochemical mechanisms of perfluoroalkyl substances (PFAS) neurotoxic action

Brown-Leung, J. M., & Cannon, J. R. (2023) · Advances in neurotoxicology · doi:10.1016/bs.ant.2023.08.002 · Cited by 5

PFOS sub-chronic exposure selectively activates Aβ clearance pathway to improve the cognitive ability of AD mice

Zhang, H., Zhang, C., Wang, Q., Fu, W., Xing, W., Jin, P., Wu, H., Bu, Y., Xu, D., & Xu, D. (2024) · Environmental Pollution · doi:10.1016/j.envpol.2024.125031 · Cited by 4

Impact of Redox Imbalance and Mitochondrial Dysfunction on Neurotoxicity Induced by Perfluorooctanoic Acid in Male Wistar Albino Rats ( Rattus norvegicus )

Hongal, L., & David, M. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.70009 · Cited by 4

Experimental evidence of a limited impact of new-generation perfluoroalkyl substance C6O4 on differentiating human dopaminergic neurons from induced pluripotent stem cells

Nisio, A. D., Trevisan, M., Dall’Acqua, S., Pannella, M., Pappalardo, C., Ferlin, A., Foresta, C., & Toni, L. D. (2022) · Toxicology Reports · doi:10.1016/j.toxrep.2022.12.006 · Cited by 4

PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model

Yang, J., Wang, Y., Xia, Y., Ren, Y., Wang, Z., Meng, X., Li, S., Liu, X., & Shao, J. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04109-9 · Cited by 5

A toxicogenomics-based identification of potential mechanisms and signaling pathways involved in PFCs-induced cancer in human

Dehghani, Z., Ranjbar, S., Shahabinezhad, F., Sabouri, P., & Mohammadi‐Bardbori, A. (2024) · Toxicology Research · doi:10.1093/toxres/tfae151 · Cited by 4

Thyroid Hormone Neuroprotection Against Perfluorooctane Sulfonic Acid Cholinergic and Glutamatergic Disruption and Neurodegeneration Induction

Moyano, P. M., Guzmán, G., Flores, A., García, J., Guerra-Menéndez, L., Sanjuan, J., Plaza, J. C., Abascal, L., Sierra, O. M., & del Pino, J. (2024) · Biomedicines · doi:10.3390/biomedicines12112441 · Cited by 3

PFOS promotes Alzheimer’s disease through aggravating the cell apoptosis and AKT/GSK3β/NF-κB/NLRP3 pathway mediated inflammation

Li, M., Ping, X., Song, H., Sun, J. W., Yang, Q., & Gao, L. (2026) · Toxicology · doi:10.1016/j.tox.2026.154423 · Cited by 3

Impact of per- and polyfluoroalkyl substances (PFAS) on brain development and function

Ko, M. Y., Min, E., Hyun, S., & Ka, M. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116348 · Cited by 3

Neurotoxicity of poly- and perfluoroalkyl substances (PFAS): Epidemiological and rodent studies of behavioral outcomes

O’Shaughnessy, K. L., Oshiro, W. M., Jackson, T. W., Starnes, H. M., Sasser, A. L., & McMichael, B. D. (2023) · Advances in neurotoxicology · doi:10.1016/bs.ant.2023.09.002 · Cited by 2

Distinct Effects of PFOS and OBS on Neurotoxicity via PMK-1 Mediated Pathway in Caenorhabditis elegans

Jiang, J., Liu, Q., Zhang, B., Zhao, L., & Xu, D. (2025) · Toxics · doi:10.3390/toxics13080662 · Cited by 2

Identification of potential mechanisms of cognitive dysfunction induced by environmentally relevant PFAS mixture in male rats

Li, B., Xu, Y., Guo, X., Wang, M., Li, X., Chen, Z., Wei, Z., Ma, D., & Yun, K. (2026) · Environment International · doi:10.1016/j.envint.2026.110093 · Cited by 2

Photoperiod perturbations impact perfluorohexane sulfonate (PFHxS) induced developmental toxicity

Ferdous, S. R., Rojas, A., Frank, C., Berry, Y., Sabatini, H. M., Luo, X., Sharma, S., Thummel, R., Chouinard, C. D., & Dasgupta, S. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141607 · Cited by 2

Insights into the Neurotoxicology of Traditional and Emerging Per- and Polyfluoroalkyl Substances: Mechanisms and Research Frontiers

Ren, Z., Wang, X., Meng, L., Ren, D., Sun, J., Cai, Y., Duan, Y., Ning, X., Ku, T., & Sang, N. (2026) · Environment & Health · doi:10.1021/envhealth.5c00628 · Cited by 2

Involvement of HECT-type E3 ubiquitin ligase genes in salt chemotaxis learning in Caenorhabditis elegans

Ike, Y., Tomioka, M., & Iino, Y. (2022) · Genetics · doi:10.1093/genetics/iyac025 · Cited by 2

Metabolomics using high-resolution magic angle spinning nuclear magnetic resonance: Neurotoxicological applications

Neita, R., Hynes, K., Mercer, G. V., Schneider, C., & Cahill, L. S. (2025) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2025.108382 · Cited by 2

Tracking Contaminant Trends: PFAS, Metals and Metalloids in Indo-Pacific Bottlenose (Tursiops aduncus) and Common Dolphins (Delphinus delphis) from South Australia

Souter, R., Lettoof, D. C., Kemper, C. M., Woolford, L., Chaber, A., Möller, L. M., Gaylard, S. G., Tomo, I., Bossley, M. I., Stevenson, G. J., et al. (2026) · Archives of Environmental Contamination and Toxicology · doi:10.1007/s00244-025-01179-w · Cited by 2

Associations of per- and polyfluoroalkyl substances with risk for depressive disorder: mixtures approachPreprint

Wang, M., Liu, J., Zhang, L., He, Y., Zhao, Y., & Zheng, S. (2024) · Research Square · doi:10.21203/rs.3.rs-3852505/v1 · Cited by 2

Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization

Jiang, Z., Wei, C., & Ma, A. (2026) · Neurotoxicity Research · doi:10.1007/s12640-026-00780-8 · Cited by 1

Neurobehavioral Impacts of the Autism Risk Gene, WAC: Studies Involving C. elegans and Mice

Boonpraman, N., Kim, D.-W., Tislerics, E., Barot, J., Pacheco-Cruz, D., Kuhn, N. C., Vogt, D. L., & Sammi, S. R. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05964-z · Cited by 1

Cellular Lipid Homeostasis and Oxidative Stress Responses in the Liver of Atlantic Cod (Gadus morhua) Exposed to a Quantifiable Measure of Climate Change (CO2) and Perfluorooctane Sulfonate (PFOS)

Lorentzen, K. (2013) · BIBSYS Brage (BIBSYS (Norway)) · Cited by 1

Examining perfluorohexane sulfonate (PFHxS) impacts on sensorimotor and circadian rhythm developmentPreprint

Ferdous, S. R., Rojas, A., Frank, C., Sabatini, H. M., Luo, X., Sharma, S., Thummel, R., Chouinard, C. D., & Dasgupta, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.08.617320 · Cited by 1

PERFLUOROOCTANESULFONIC ACID (PFOS) AS A POTENTIAL RISK FACTOR FOR LATE-ONSET ALZHEIMER’S DISEASE

Basaly, V. (2020) · doi:10.23860/thesis-basaly-veronia-2020

Effects of perfluorooctane sulphonate subchronic exposure on learning and memory abilities and hippocampal neurons in mice

Chen, N. (2013) · Journal of environmental health · Cited by 1

Neurotoxic effects of lactational exposure to perfluorooctane sulfonate on learning and memory in adult male mouse

Mshaty, A., Haijima, A., Takatsuru, Y., Ninomiya, A., Yajima, H., Kokubo, M., Khairinisa, M. A., Miyazaki, W., Amano, I., & Koibuchi, N. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111710 · Cited by 50

Perfluorooctane sulfonate (PFOS) and calcium channel downstream signaling molecules

Wang, Y., & Jin, Y. (2012) · Toxicology Research · doi:10.1039/c2tx20017a · Cited by 9

Effects of subchronic perfluorooctane sulfonate exposure of rats on calcium-dependent signaling molecules in the brain tissue

Liu, X., Liu, W., Jin, Y., Yu, W., Liu, L., & Yu, H. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0517-9 · Cited by 50

Perfluorooctane Sulfonate (PFOS) Exposure Could Modify the Dopaminergic System in Several Limbic Brain Regions

Salgado, R., López-Doval, S., Pereiro, N., & Lafuente, A. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2015.10.023 · Cited by 58