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Cited by 327

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable

Open access
Duvivier, Bernard M. F. M., Schaper, Nicolaas C., Bremers, Michelle A., van Crombrugge, Glenn, Menheere, Paul P. C. A., Kars, Marleen, Savelberg, Hans H. C. M.·2013·PLoS ONE
DOI 10.1371/journal.pone.0055542
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Abstract

BACKGROUND: Epidemiological studies suggest that excessive sitting time is associated with increased health risk, independent of the performance of exercise. We hypothesized that a daily bout of exercise cannot compensate the negative effects of inactivity during the rest of the day on insulin sensitivity and plasma lipids. METHODOLOGY/PRINCIPAL FINDINGS: Eighteen healthy subjects, age 21±2 year, BMI 22.6±2.6 kgm(-2) followed randomly three physical activity regimes for four days. Participants were instructed to sit 14 hr/day (sitting regime); to sit 13 hr/day and to substitute 1 hr of sitting with vigorous exercise 1 hr (exercise regime); to substitute 6 hrs sitting with 4 hr walking and 2 hr standing (minimal intensity physical activity (PA) regime). The sitting and exercise regime had comparable numbers of sitting hours; compared to the exercise regime, the minimal intensity PA regime had a higher estimated daily energy expenditure (238kcal/day) [corrected]. PA was assessed continuously by an activity monitor (ActivPAL) and a diary. Measurements of insulin sensitivity (oral glucose tolerance test, OGTT) and plasma lipids were performed in the fasting state, the morning after the 4 days of each regime. In the sitting regime, daily energy expenditure was about 500 kcal lower than in both other regimes. Area under the curve for insulin during OGTT was significantly lower after the minimal intensity PA regime compared to both sitting and exercise regimes 6727.3±4329.4 vs 7752.0±3014.4 and 8320.4±5383.7 mU•min/ml, respectively. Triglycerides, non-HDL cholesterol and apolipoprotein B plasma levels improved significantly in the minimal intensity PA regime compared to sitting and showed non-significant trends for improvement compared to exercise. CONCLUSIONS: One hour of daily physical exercise cannot compensate the negative effects of inactivity on insulin level and plasma lipids if the rest of the day is spent sitting. Reducing inactivity by increasing the time spent walking/standing is more effective than one hour of physical exercise, when energy expenditure is kept constant.

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Citations

Cites

Show all 10 references

Research works printed but not linked: 24

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Metadata

Authors
Duvivier, B. M. F. M., Schaper, N. C., Bremers, M. A., van Crombrugge, G., Menheere, P. P. C. A., Kars, M., & Savelberg, H. H. C. M.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-02-13
Volume
8
Issue
2
Pages
e55542
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0055542
OpenAlex
W2081838234
Cited by
327
References
10
FWCI
27.34
Type
journal article
Language
en
Update notices
correction (2014-08-05)
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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CoChat. (2026). Citation check: Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable. https://app.cochat.ai/papers/10.1371/journal.pone.0055542
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Duvivier, B. M. F. M., Schaper, N. C., Bremers, M. A., van Crombrugge, G., Menheere, P. P. C. A., Kars, M., & Savelberg, H. H. C. M. (2013). Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable. PLoS ONE. https://doi.org/10.1371/journal.pone.0055542

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