Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 327

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Minimal Intensity Physical Activity (Standing and Walking) of Longer Duration Improves Insulin Action and Plasma Lipids More than Shorter Periods of Moderate to Vigorous Exercise (Cycling) in Sedentary Subjects When Energy Expenditure Is Comparable

Open access
Duvivier, Bernard M. F. M., Schaper, Nicolaas C., Bremers, Michelle A., van Crombrugge, Glenn, Menheere, Paul P. C. A., Kars, Marleen, Savelberg, Hans H. C. M.·2013·PLoS ONE
DOI 10.1371/journal.pone.0055542
Open this paper in CoChat — free account

Abstract

BACKGROUND: Epidemiological studies suggest that excessive sitting time is associated with increased health risk, independent of the performance of exercise. We hypothesized that a daily bout of exercise cannot compensate the negative effects of inactivity during the rest of the day on insulin sensitivity and plasma lipids. METHODOLOGY/PRINCIPAL FINDINGS: Eighteen healthy subjects, age 21±2 year, BMI 22.6±2.6 kgm(-2) followed randomly three physical activity regimes for four days. Participants were instructed to sit 14 hr/day (sitting regime); to sit 13 hr/day and to substitute 1 hr of sitting with vigorous exercise 1 hr (exercise regime); to substitute 6 hrs sitting with 4 hr walking and 2 hr standing (minimal intensity physical activity (PA) regime). The sitting and exercise regime had comparable numbers of sitting hours; compared to the exercise regime, the minimal intensity PA regime had a higher estimated daily energy expenditure (238kcal/day) [corrected]. PA was assessed continuously by an activity monitor (ActivPAL) and a diary. Measurements of insulin sensitivity (oral glucose tolerance test, OGTT) and plasma lipids were performed in the fasting state, the morning after the 4 days of each regime. In the sitting regime, daily energy expenditure was about 500 kcal lower than in both other regimes. Area under the curve for insulin during OGTT was significantly lower after the minimal intensity PA regime compared to both sitting and exercise regimes 6727.3±4329.4 vs 7752.0±3014.4 and 8320.4±5383.7 mU•min/ml, respectively. Triglycerides, non-HDL cholesterol and apolipoprotein B plasma levels improved significantly in the minimal intensity PA regime compared to sitting and showed non-significant trends for improvement compared to exercise. CONCLUSIONS: One hour of daily physical exercise cannot compensate the negative effects of inactivity on insulin level and plasma lipids if the rest of the day is spent sitting. Reducing inactivity by increasing the time spent walking/standing is more effective than one hour of physical exercise, when energy expenditure is kept constant.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0055542

Cites

10 of 10 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 10 references

Research works printed but not linked: 24

  1. KI Proper, 2011, Sedentary Behaviors and Health Outcomes Among Adults: A Systematic Review of Prospective Studies, American Journal of Preventive Medicine, 40, 174, 10.1016/j.amepre.2010.10.015 · DOI · Paper page
  2. L Bey, 2003, Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity, The Journal of Physiology, 551, 673, 10.1113/jphysiol.2003.045591 · DOI · Paper page
  3. Healy GN, Dunstan DW, Salmon J, Shaw JE, ZIimmet PZ, <etal>et al</etal>.. (2008) Television Time and Continuous Metabolic Risk in Physically Active Adults. Medicine & Science in Sports & Exercise 40: 639–645 610.1249/MSS.1240b1013e3181607421. · DOI · Paper page
  4. A Bankoski, 2011, Sedentary Activity Associated With Metabolic Syndrome Independent of Physical Activity, Diabetes Care, 34, 497, 10.2337/dc10-0987 · DOI · Paper page
  5. BR Stephens, 2011, Effects of 1 day of inactivity on insulin action in healthy men and women: interaction with energy intake, Metabolism, 60, 941, 10.1016/j.metabol.2010.08.014 · DOI
  6. J Hawley, 2012, What’s new since Hippocrates? Preventing type 2 diabetes by physical exercise and diet, Diabetologia, 55, 535, 10.1007/s00125-012-2460-1 · DOI
  7. JM Tucker, 2011, Physical Activity in U.S. Adults: Compliance with the Physical Activity Guidelines for Americans, American Journal of Preventive Medicine, 40, 454, 10.1016/j.amepre.2010.12.016 · DOI · Paper page
  8. PM Grant, 2006, The validation of a novel activity monitor in the measurement of posture and motion during everyday activities, Br J Sports Med, 40, 992, 10.1136/bjsm.2006.030262 · DOI · Paper page
  9. HK Hiilloskorpi, 2003, Use of heart rate to predict energy expenditure from low to high activity levels, Int J Sports Med, 24, 332, 10.1055/s-2003-40701 · DOI
  10. WT Friedewald, 1972, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin Chem, 18, 499, 10.1093/clinchem/18.6.499 · DOI · Paper page
  11. M Matsuda, 1999, Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp, Diabetes Care, 22, 1462, 10.2337/diacare.22.9.1462 · DOI · Paper page
  12. C Tudor-Locke, 2004, How Many Steps/Day Are Enough?: Preliminary Pedometer Indices for Public Health, Sports Medicine, 34, 1, 10.2165/00007256-200434010-00001 · DOI · Paper page
  13. Sp Blanc, 2000, Fuel Homeostasis during Physical Inactivity Induced by Bed Rest, Journal of Clinical Endocrinology & Metabolism, 85, 2223
  14. R Yanagibori, 1997, The effects of 20 days bed rest on serum lipids and lipoprotein concentrations in healthy young subjects, J Gravit Physiol, 4, S82
  15. F Magkos, 2006, No effect of menstrual cycle phase on basal very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics, American Journal of Physiology - Endocrinology And Metabolism, 291, E1243, 10.1152/ajpendo.00246.2006 · DOI
  16. S Praet, 2008, Brisk walking compared with an individualised medical fitness programme for patients with type 2 diabetes: a randomised controlled trial, Diabetologia, 51, 736, 10.1007/s00125-008-0950-y · DOI
  17. TT van Sloten, 2011, Peripheral neuropathy, decreased muscle strength and obesity are strongly associated with walking in persons with type 2 diabetes without manifest mobility limitations, Diabetes Research and Clinical Practice, 91, 32, 10.1016/j.diabres.2010.09.030 · DOI
  18. EP Meijer, 1999, Effect of exercise training on total daily physical activity in elderly humans, Eur J Appl Physiology Occup Physiol, 80, 16, 10.1007/s004210050552 · DOI
  19. CE Matthews, 2012, Amount of time spent in sedentary behaviors and cause-specific mortality in US adults, The American Journal of Clinical Nutrition, 95, 437, 10.3945/ajcn.111.019620 · DOI · Paper page
  20. HP van der Ploeg, 2012, Sitting Time and All-Cause Mortality Risk in 222 497 Australian Adults, Arch Intern Med, 172, 494, 10.1001/archinternmed.2011.2174 · DOI · Paper page
  21. R Yanagibori, 1994, Carbohydrate and lipid metabolism after 20 days of bed rest, Acta Physiol Scand, 616, 51
  22. A Bergouignan, 2011, Physical inactivity as the culprit of metabolic inflexibility: evidence from bed-rest studies, Journal of Applied Physiology, 111, 1201, 10.1152/japplphysiol.00698.2011 · DOI · Paper page
  23. DW Dunstan, 2012, Breaking up prolonged sitting reduces postprandial glucose and insulin responses, Diabetes Care, 35, 976, 10.2337/dc11-1931 · DOI · Paper page
  24. E Ekblom-Bak, 2011, Are we facing a new paradigm of inactivity physiology?, Br J Sport Med, 44, 834, 10.1136/bjsm.2009.067702 · DOI

Cited by

Metadata

Authors
Duvivier, B. M. F. M., Schaper, N. C., Bremers, M. A., van Crombrugge, G., Menheere, P. P. C. A., Kars, M., & Savelberg, H. H. C. M.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-02-13
Volume
8
Issue
2
Pages
e55542
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0055542
OpenAlex
W2081838234
Cited by
327
References
10
FWCI
27.34
Type
journal article
Language
en
Update notices
correction (2014-08-05)
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.