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Cited by 161Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Inflammatory Proteins in Plasma Are Associated with Severity of Alzheimer’s Disease

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Leung, Rufina, Proitsi, Petroula, Simmons, Andrew, Lunnon, Katie, Güntert, Andreas, Kronenberg, Deborah, Pritchard, Megan, Tsolaki, Magda, Mecocci, Patrizia, Kloszewska, Iwona, Vellas, Bruno, Soininen, Hilkka, Wahlund, Lars-Olaf, Lovestone, Simon·2013·PLoS ONE
DOI 10.1371/journal.pone.0064971PMC PMC3677891
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Abstract

Markers of Alzheimer's disease (AD) are being widely sought with a number of studies suggesting blood measures of inflammatory proteins as putative biomarkers. Here we report findings from a panel of 27 cytokines and related proteins in over 350 subjects with AD, subjects with Mild Cognitive Impairment (MCI) and elderly normal controls where we also have measures of longitudinal change in cognition and baseline neuroimaging measures of atrophy. In this study, we identify five inflammatory proteins associated with evidence of atrophy on MR imaging data particularly in whole brain, ventricular and entorhinal cortex measures. In addition, we observed six analytes that showed significant change (over a period of one year) in people with fast cognitive decline compared to those with intermediate and slow decline. One of these (IL-10) was also associated with brain atrophy in AD. In conclusion, IL-10 was associated with both clinical and imaging evidence of severity of disease and might therefore have potential to act as biomarker of disease progression.

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Crossref · 10.1371/journal.pone.0064971

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Figure 1 Association between inflammatory proteins levels measured in plasma versus ventricular volume. Scatter diagram with regression lines show the relationship between proteins levels of IL-1ra (N = 86) (figure 1A), IL-6 (N = 83) (figure 1B) and IL-10 (N = 38)(figure 1C)and ventricular volume in the three separate diagnostic groups. Keys: Blue line and dots denote control samples; orange line and dots denote MCI samples; red line and dots denote AD samples; brown dotted line denotes 95% CI.
Figure 1 Association between inflammatory proteins levels measured in plasma versus ventricular volume. Scatter diagram with regression lines show the relationship between proteins levels of IL-1ra (N = 86) (figure 1A), IL-6 (N = 83) (figure 1B) and IL-10 (N = 38)(figure 1C)and ventricular volume in the three separate diagnostic groups. Keys: Blue line and dots denote control samples; orange line and dots denote MCI samples; red line and dots denote AD samples; brown dotted line denotes 95% CI.CC BY · PubMed Central
Figure 2 Inflammatory proteins levels at Visit 1 (baseline) and Visit 2 (one year follow up from baseline) for the three ADAS-cog cognitive decline groups. Linear mixed effects models indicated significant yearly changes in the log-transformed IL-2 (figure 2A), IL-4 (figure 2B), IL-10 (figure 2C), G-CSF (figure 2D), IFN-γ (figure 2E), and PDGF (figure 2F) (pg/ml) inflammatory protein levels between the three cognitive decline groups, after adjusting for covariates. Slow indicates slow decliner. Inter indicates intermediate decliner. Fast indicates fast decliner Key: 1– Visit 1(Baseline); 2– Visit 2 (one year follow up from baseline).
Figure 2 Inflammatory proteins levels at Visit 1 (baseline) and Visit 2 (one year follow up from baseline) for the three ADAS-cog cognitive decline groups. Linear mixed effects models indicated significant yearly changes in the log-transformed IL-2 (figure 2A), IL-4 (figure 2B), IL-10 (figure 2C), G-CSF (figure 2D), IFN-γ (figure 2E), and PDGF (figure 2F) (pg/ml) inflammatory protein levels between the three cognitive decline groups, after adjusting for covariates. Slow indicates slow decliner. Inter indicates intermediate decliner. Fast indicates fast decliner Key: 1– Visit 1(Baseline); 2– Visit 2 (one year follow up from baseline).CC BY · PubMed Central

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Research works printed but not linked: 1

  1. Soares HD, Potter WZ, Pickering E, Kuhn M, Immermann FW, <etal>et al</etal>.. (2012) Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease. Arch Neurol: 1–8. · DOI · Paper page

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Metadata

Authors
Leung, R., Proitsi, P., Simmons, A., Lunnon, K., Güntert, A., Kronenberg, D., Pritchard, M., Tsolaki, M., Mecocci, P., Kloszewska, I., Vellas, B., Soininen, H., Wahlund, L.-O., & Lovestone, S.
Affiliations
  • King's College London (GB)
  • Aristotle University of Thessaloniki (GR)
  • University of Perugia (IT)
  • Inserm (FR)
  • University of Eastern Finland (FI)
Corresponding author
Lovestone, Simon
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2013-06-10
Volume
8
Issue
6
Pages
e64971
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0064971
PMC
PMC3677891
OpenAlex
W2086474013
Cited by
160
References
43
Citations by year
2026: 4 · 2025: 15 · 2024: 18 · 2023: 12 · 2022: 13 · 2021: 19 · 2020: 13 · 2019: 9 · 2018: 15 · 2017: 10 · 2016: 6 · 2015: 15 · 2014: 9 · 2013: 2
FWCI
7.58
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Open Research Exeter (University of Exeter) (publishedVersion, other-oa)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Research Portal (King's College London) (submittedVersion, other-oa)
Funders
  • South London and Maudsley NHS Foundation Trust
  • Wellcome Trust (100140)
  • National Institute for Health and Care Research (NF-SI-0512-10053)
  • King's College London
  • European Commission (FP6-2004-LIFESCIHEALTH-5)
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, inflammatory proteins, cytokines, biomarkers, disease severity, mild cognitive impairment, brain atrophy, entorhinal cortex, ventriculomegaly, IL-10, cognitive decline, disease progression, neuroimaging
MeSH terms
Aged, Alzheimer Disease, Atrophy, Brain, Cognition Disorders, Enzyme-Linked Immunosorbent Assay, Female, Humans, Magnetic Resonance Imaging, Male, Prognosis, Severity of Illness Index, Cohort Studies, Biomarkers, Case-Control Studies, Cytokines, Disease Progression, Inflammation Mediators, Functional Neuroimaging

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