Cited by 85Skin Protection and AgingProbiotics and Fermented Foodsmelanin and skin pigmentation

Oral administration of Lactobacillus plantarum HY7714 protects hairless mouse against ultraviolet B-induced photoaging

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Kim, Hyun Mee, Lee, Dong Eun, Park, Soo Dong, Kim, Yong-Tae, Kim, Yu Jin, Jeong, Ji Woong, Jang, Sung Sik, Ahn, Young-Tae +4 more·2014·Journal of Microbiology and Biotechnology

Abstract

Ultraviolet (UV) irradiation alters multiple molecular pathways in the skin, thereby inducing skin damage, including photoaging. In recent years, probiotics have gained interest due to their beneficial effects on skin health, such as inhibiting atopic dermatitis and improving skin immunity or inflammation. However, little is known about the effects of probiotics on UVBinduced photoaging. In this study, we evaluated the effect of Lactobacillus plantarum HY7714 against UVB-induced photoaging in human dermal fibroblasts and hairless mice. The results showed that L. plantarum HY7714 treatment effectively rescued UVB-reduced procollagen expression through the inhibition of UVB-induced matrix metalloproteinase (MMP)-1 expression in human dermal fibroblasts. Data from a western blot showed that L. plantarum HY7714 inhibited the phosphorylation of Jun N-terminal kinase, thereby suppressing the UVB-induced phosphorylation and expression of c-Jun. Oral administration of L. plantarum HY7714 clearly inhibited the number, depth, and area of wrinkles in hairless mouse skin. Histological data showed that L. plantarum HY7714 significantly inhibited UVB-induced epidermal thickness in mice. Western blot and zymography data also revealed that L. plantarum HY7714 effectively inhibited MMP-13 expression as well as MMP-2 and -9 activities in dermal tissue. Collectively, these results provide further insight regarding the skin biological actions of L. plantarum HY7714, a potential skin anti-photoaging agent.

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Crossref · 10.4014/jmb.1406.06038

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  • Oral probiotics may counteract UV damage and relieve inflammatory dermatoses by regulating immune-related signal pathways.

    “Oral probiotics may counteract UV damage [80] and relieve inflammatory dermatoses [81] by regulating immune-related signal pathways.”

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Research works printed but not linked: 1

  1. Foolad N, Brezinski EA, Chase EP, Armstrong AW. 2013. Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids. JAMA Dermatol. 149: 350-355.

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Authors
Kim, H. M., Lee, D. E., Park, S. D., Kim, Y.-T., Kim, Y. J., Jeong, J. W., Jang, S. S., Ahn, Y.-T., Sim, J.-H., Huh, C.-S., Chung, D. K., & Lee, J.-H.
Affiliations
  • Korea Yakult (South Korea) (KR)
  • Seoul National University (KR)
  • Kyung Hee University (KR)
Venue
Journal of Microbiology and Biotechnology
Published
2014-11-28
Volume
24
Issue
11
Pages
1583-1591
ISSN
  • 1017-7825 (ISSN-L)
  • 1738-8872
OpenAlex
W2397476561
Cited by
85
References
27
Citations by year
2026: 6 · 2025: 4 · 2024: 9 · 2023: 12 · 2022: 18 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 1
FWCI
4.01
Type
journal article
Language
en
Open access
Locations
  • Journal of Microbiology and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
probiotics, photoaging, UVB irradiation, skin aging, dermal fibroblasts, MMP-1, matrix metalloproteinase-13, JNK phosphorylation, c-Jun, wrinkles, epidermal thickness, MMP-2, MMP-9, hairless mouse skin
MeSH terms
Administration, Oral, Animals, Cell Line, Female, Humans, Mice, Hairless, Procollagen, Ultraviolet Rays, Skin Aging, Probiotics, Matrix Metalloproteinase 1, Lactiplantibacillus plantarum, Mice

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