Randomised double-blind placebo-controlled study of the effect of Lactobacillus paracasei NCC 2461 on skin reactivity
Open accessAbstract
In recent decades, the prevalence of subjects with reactive skin has considerably increased in industrialised countries. 50% of women and 30% of men report cutaneous discomfort classified under reactive/sensitive skin. Several topical approaches have been proposed, in particular through improvement of galenic forms or protection of epidermal surface. We propose to act differently, deeply from inside the body via an innovative nutritional approach. To this purpose, Lactobacillus paracasei NCC 2461 (ST11) was selected because of its specific beneficial skin properties discovered in in vitro studies, i.e. diminution of neurogenic inflammation and promotion of the recovery of skin barrier function. We designed a randomised double-blind placebo-controlled clinical study with a two-month supplementation in two female treatment groups (n=32 per group). A capsaicin test was performed to monitor the time course of skin sensitivity. Moreover, transepidermal water loss was assessed to analyse the rate of skin barrier function recovery; dryness of the leg and roughness of the cheeks was investigated by a dermatologist as well as by self-assessment. The results of the present clinical trial show that oral supplementation with the probiotic decreases skin sensitivity and increases the rate of barrier function recovery. Thus, the data provide evidence that daily intake of ST11 could improve reactive skin condition.
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In a randomized double-blind placebo-controlled clinical trial, lactobacillus paracasei NCC 2461 decreased skin sensitivity through inhibition of release of neuromediators involved in sensitivity reaction, and improved skin barrier function in leg and cheek skin.
“A randomized, double-blind, placebo-controlled clinical trial showed that lactobacillus paracasei NCC 2461 decreased skin sensitivity through inhibition of the release of the neuromediators involved in sensitivity reaction, and improved skin barrier function in leg and cheek skin [142].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [142]
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Peaux sensibles, peaux réactives
Misery, L. (2017)
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- Authors
- Gueniche, A., Philippe, D., Bastien, P., Reuteler, G., Blum, S., Castiel-Higounenc, I., Breton, L., & Benyacoub, J.
- Affiliations
- L’Oréal Research and Innovation, 1 avenue Eugène shueller, 93 601 Aulnay sous Bois, France
- Nestlé (Switzerland) (CH)
- L'Oréal (France) (FR)
- Venue
- Beneficial Microbes
- Publisher
- Walter de Gruyter GmbH
- Published
- 2014-06-01
- Volume
- 5
- Issue
- 2
- Pages
- 137-145
- ISSN
- 1876-2883 (ISSN-L)
- 1876-2891
- OpenAlex
- W2104922674
- Cited by
- 114
- References
- 35
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 8 · 2022: 17 · 2021: 20 · 2020: 14 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 1
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Beneficial Microbes (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- probiotics, sensitive skin, skin barrier function, transepidermal water loss, oral supplementation, neurogenic inflammation, dry skin, skin roughness
- MeSH terms
- Administration, Oral, Capsaicin, Dehydration, Dermatitis, Double-Blind Method, Humans, Lactobacillus, Placebos, Skin Diseases, Skin Physiological Phenomena, Treatment Outcome, Probiotics
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