A selective gut bacterial bile salt hydrolase alters host metabolism
Open accessAbstract
The human gut microbiota impacts host metabolism and has been implicated in the pathophysiology of obesity and metabolic syndromes. However, defining the roles of specific microbial activities and metabolites on host phenotypes has proven challenging due to the complexity of the microbiome-host ecosystem. Here, we identify strains from the abundant gut bacterial phylum Bacteroidetes that display selective bile salt hydrolase (BSH) activity. Using isogenic strains of wild-type and BSH-deleted Bacteroides thetaiotaomicron, we selectively modulated the levels of the bile acid tauro-β-muricholic acid in monocolonized gnotobiotic mice. B. thetaiotaomicron BSH mutant-colonized mice displayed altered metabolism, including reduced weight gain and respiratory exchange ratios, as well as transcriptional changes in metabolic, circadian rhythm, and immune pathways in the gut and liver. Our results demonstrate that metabolites generated by a single microbial gene and enzymatic activity can profoundly alter host metabolism and gene expression at local and organism-level scales.
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Bacteroides dorei possesses high BSH activity in vitro.
“B. Dorei possesses high BSH activity in vitro (Yao et al., 2018)”
From Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway (2023) · cites this paper as Yao et al., 2018
The Materials and methods list two Bacteroides dorei strains, and the Results describe an in vitro BSH-activity screen of the Bacteroidetes strains. The text available for that screen does not state that B. dorei had high activity; that degree of activity is unsupported. (LLM, conf=0.76)
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Identification and Characterization of Major Bile Acid 7α-Dehydroxylating Bacteria in the Human Gut
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Integrating the gut microbiome and pharmacology
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- Authors
- Yao, L., Seaton, S. C., Ndousse-Fetter, S., Adhikari, A. A., DiBenedetto, N., Mina, A. I., Banks, A. S., Bry, L., & Devlin, A. S.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Devlin, A Sloan
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2018-07-17
- Volume
- 7
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC6078496
- OpenAlex
- W2884910880
- Cited by
- 274
- References
- 90
- Citations by year
- 2026: 28 · 2025: 33 · 2024: 41 · 2023: 28 · 2022: 45 · 2021: 41 · 2020: 32 · 2019: 23 · 2018: 3
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (P30DK034854)
- Wellington Postdoctoral Fellowship
- Massachusetts Institute of Technology (Center for Microbiome Informatics and Therapeutics – Innovation Award)
- Karin Grunebaum Cancer Research Foundation (Junior Faculty Award)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- bile salt hydrolase, Bacteroides thetaiotaomicron, gut microbiota, host metabolism, bile acids, obesity, metabolic syndrome, gnotobiotic mice, respiratory exchange ratio, circadian rhythm, immune gene expression, microbial metabolites
- MeSH terms
- Bacteroides thetaiotaomicron, Host Microbial Interactions, Amidohydrolases, Animals, Body Weight, Circadian Rhythm, Germ-Free Life, Immunity, Intestines, Liver, Metabolism, Respiration, Taurocholic Acid, Gene Expression Profiling, Gastrointestinal Tract, Mice
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