Oxidative Stress in COPD

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010.

Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., Abraham, J., Adair, T., Aggarwal, R., Ahn, S. Y., et al. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61728-0 · Cited by 14,070

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

Beckman, J. S., & Koppenol, W. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1424 · Cited by 5,513

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622

The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease

Hogg, J. C., Chu, F. S. F., Utokaparch, S., Woods, R. R., Elliott, W. M., Buzatu, L., Cherniack, R. M., Rogers, R. M., Sciurba, F. C., Coxson, H. O., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032158 · Cited by 3,828

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system1 1This review is based on the licentiate thesis “Thioredoxin reductase—interactions with the redox active compounds 1-chloro-2,4-dinitrobenzene and lipoic acid” by Jonas Nordberg, 2001, Karolinska Institute, Stockholm, ISBN 91-631-1064-4.

Nordberg, J., & Arnér, E. S. J. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00724-9 · Cited by 2,720

Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis

Gold, R., Kappos, L., Arnold, D. L., Bar‐Or, A., Giovannoni, G., Selmaj, K. W., Tornatore, C., Sweetser, M. T., Yang, M., Sheikh, S. I., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114287 · Cited by 1,765

Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial

Burge, P. S. (2000) · BMJ · doi:10.1136/bmj.320.7245.1297 · Cited by 1,669

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496

Immunology of asthma and chronic obstructive pulmonary disease

Barnes, P. J. (2008) · Nature reviews. Immunology · doi:10.1038/nri2254 · Cited by 1,444

Chronic obstructive pulmonary disease in non-smokers

Salvi, S., & Barnes, P. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61303-9 · Cited by 1,384

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

McDonough, J. E., Yuan, R., Suzuki, M., Seyednejad, N., Elliott, W. M., Sánchez, P. G., Wright, A. C., Gefter, W. B., Litzky, L. A., Coxson, H. O., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1106955 · Cited by 1,208

Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea

Pryor, W. A., & Stone, K. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39148.x · Cited by 1,179

Heme Oxygenase-1: Function, Regulation, and Implication of a Novel Stress-Inducible Protein in Oxidant-Induced Lung Injury

Choi, A. M., & Alam, J. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.1.8679227 · Cited by 1,126

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

Kasahara, Y., Tuder, R. M., Taraseviciene‐Stewart, L., Cras, T. D. L., Abman, S. H., Hirth, P., Waltenberger, J. L., & Voelkel, N. F. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10259 · Cited by 1,110

Antioxidant Therapy: A New Pharmacological Approach in Shock, Inflammation, and Ischemia/Reperfusion Injury

Cuzzocrea, S., Riley, D. P., Caputi, A. P., & Salvemini, D. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01484-4 · Cited by 1,087

Long-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking

PAUWELS, R. A., Löfdahl, C., Laitinen, L. A., Schouten, J. P., Postma, D. S., Pride, N. B., & Ohlsson, S. V. (1999) · New England Journal of Medicine · doi:10.1056/nejm199906243402503 · Cited by 1,071

Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease

Ito, K., Ito, M., Elliott, W. M., Cosío, B. G., Caramori, G., Kon, O. M., Barczyk, A., Hayashi, S., Adcock, I. M., Hogg, J. C., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa041892 · Cited by 987

Glucocorticoid resistance in inflammatory diseases

Barnes, P. J., & Adcock, I. M. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60326-3 · Cited by 983

Protein carbonylation in human diseases

Dalle-Donne, I., Giustarini, D., Colombo, R., Rossi, R., & Milzani, A. (2003) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(03)00031-5 · Cited by 961

Reactive oxygen species and cell signaling: Respiratory burst in macrophage signaling

Forman, H. J., & Torres, M. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2206007 · Cited by 891

The Pathology of Chronic Obstructive Pulmonary Disease

Hogg, J. C., & Timens, W. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092145 · Cited by 887

Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

Kobayashi, M., & Yamamoto, M. P. (2006) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2006.01.007 · Cited by 862

Oxidative Stress in Chronic Obstructive Pulmonary Disease

Repine, J. E., Bast, A., & Lankhorst, I. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.2.9611013 · Cited by 848

Exhaled Markers of Pulmonary Disease

Kharitonov, S. A., & Barnes, P. J. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.7.2009041 · Cited by 837

Effect of Inhaled Triamcinolone on the Decline in Pulmonary Function in Chronic Obstructive Pulmonary Disease

The Lung Health Study Research Group (2000) · New England Journal of Medicine · doi:10.1056/nejm200012283432601 · Cited by 824

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

Cosío, M. G., Saetta, M. P., & Agustí, A. G. N. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804752 · Cited by 823

Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial

Vestbo, J., Søorensen, T., Lange, P., Brix, A., Torre, P., & Viskum, K. (1999) · The Lancet · doi:10.1016/s0140-6736(98)10019-3 · Cited by 814

Systemic oxidative stress in asthma, COPD, and smokers

Rahman, I., Morrison, D., Donaldson, K., & MacNee, W. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.4.8887607 · Cited by 774

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

Ito, K., Barnes, P. J., & Adcock, I. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6891-6903.2000 · Cited by 723

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

Barnes, P. J. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1564 · Cited by 708

Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial

Decramer, M., Mölken, M. R., Dekhuijzen, P. R., Troosters, T., van Herwaarden, C., Pellegrino, R., van Schayck, O. C. P., Olivieri, D., Donno, M. D., Backer, W. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66456-2 · Cited by 680

Recent advances torwards understanding redox mechanisms in the activation of nuclear factor κb

Janssen-Heininger, Y. M. W., Poynter, M. E., & Baeuerle, P. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00218-5 · Cited by 666

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

Negre‐Salvayre, A., Coatrieux, C., Ingueneau, C., & Salvayre, R. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707395 · Cited by 641

COPD as a Disease of Accelerated Lung Aging

Ito, K., & Barnes, P. J. (2009) · CHEST Journal · doi:10.1378/chest.08-1419 · Cited by 634

Histone acetylation and deacetylation: importance in inflammatory lung diseases

Barnes, P. J., Adcock, I. M., & Ito, K. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00117504 · Cited by 571

Oxidative stress and lung inflammation in airways disease

MacNee, W. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)01320-6 · Cited by 557

Effects of Inhaled and Oral Glucocorticoids on Inflammatory Indices in Asthma and COPD

Keatings, V. M., Jatakanon, A., Worsdell, Y. M., & Barnes, P. J. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032192 · Cited by 549

Exhaled 8-Isoprostane as an In Vivo Biomarker of Lung Oxidative Stress in Patients with COPD and Healthy Smokers

Montuschi, P., Collins, J. V., Ciabattoni, G., Lazzeri, N., Corradi, M., Kharitonov, S. A., & Barnes, P. J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.3.2001063 · Cited by 548

Increased Exhalation of Hydrogen Peroxide in Patients With Stable and Unstable Chronic Obstructive Pulmonary Disease

Dekhuijzen, P. N., Aben, K. K., Dekker, I., Aarts, L. P., Wielders, P. L., van Herwaarden, C. L., & Bast, A. (1996) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.154.3.8810624 · Cited by 503

Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages

Ito, K., LIM, S., Caramori, G., Chung, K. F., Barnes, P. J., & Adcock, I. M. (2001) · The FASEB Journal · doi:10.1096/fj.00-0432fje · Cited by 482

Oxidative stress and glutathione in TGF-β-mediated fibrogenesis

Liu, R.-M., & Pravia, K. A. G. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.026 · Cited by 473

Granulocyte Inflammatory Markers and Airway Infection during Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Aaron, S. D., Angel, J. B., Lunau, M., Wright, K. E., Fex, C., Saux, N. L., & Dales, R. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.2.2003122 · Cited by 463

Acute and Chronic Effects of Cigarette Smoking on Exhaled Nitric Oxide

Kharitonov, S. A., Robbins, R. A., Yates, D. H., Keatings, V. M., & Barnes, P. J. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7543345 · Cited by 461

4-Hydroxy-2-Nonenal, a Specific Lipid Peroxidation Product, Is Elevated in Lungs of Patients with Chronic Obstructive Pulmonary Disease

Rahman, I., van Schadewijk, A. M., Crowther, A. J. L., Hiemstra, P. S., Stolk, J. N., MacNee, W., & de Boer, W. I. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2110101 · Cited by 460

Oxidants/antioxidants and COPD.

Macnee, W. (2000) · Chest · doi:10.1378/chest.117.5_suppl_1.303s-a · Cited by 456

Burying the Dead

Vandivier, R. W., Henson, P. M., & Douglas, I. S. (2006) · CHEST Journal · doi:10.1378/chest.129.6.1673 · Cited by 450

Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

Stefano, A. D., Caramori, G., Oates, T. M., Capelli, A., Lusuardi, M., Gnemmi, I., Ioli, F., Chung, K. F., Donner, C. F., Barnes, P. J., et al. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00272002 · Cited by 434

The Cytokine Network in Chronic Obstructive Pulmonary Disease

Barnes, P. J. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0220tr · Cited by 426

Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease

Rahman, I., & MacNee, W. (1999) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1999.277.6.l1067 · Cited by 420

Effect of High Dose Inhaled Steroid on Cells, Cytokines, and Proteases in Induced Sputum in Chronic Obstructive Pulmonary Disease

Culpitt, S. V., Maziak, W., Loukidis, S., Nightingale, J. A., MATTHEWS, J. L., & Barnes, P. J. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.5.9811058 · Cited by 414

Granulocyte Activation Markers in Induced Sputum: Comparison Between Chronic Obstructive Pulmonary Disease, Asthma, and Normal Subjects

Keatings, V. M., & Barnes, P. J. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.2.9032177 · Cited by 404

Oxidative stress and airway inflammation in severe exacerbations of COPD

Drost, E. M. (2005) · Thorax · doi:10.1136/thx.2004.027946 · Cited by 389

How Do Corticosteroids Work in Asthma?

Barnes, P. J., & Adcock, I. M. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-5_part_1-200309020-00012 · Cited by 373

Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema

Majo, J., Ghezzo, H., & Cosio, M. G. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.17509460 · Cited by 371

Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration

Ito, K., Hanazawa, T., Tomita, K., Barnes, P. J., & Adcock, I. M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.01.046 · Cited by 370

Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study

Zheng, J.-P., Kang, J., Huang, S., Chen, P., Yao, W.-Z., Yang, L., Bai, C., Wang, C., Wang, C., Chen, B.-Y., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60869-7 · Cited by 357

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

To, Y., Ito, K., Kizawa, Y., Failla, M., Ito, M., Kusama, T., Elliott, W. M., Hogg, J. C., Adcock, I. M., & Barnes, P. J. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200906-0937oc · Cited by 356

Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction

Gotoh, Y., & Cooper, J. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17477 · Cited by 355

Increase in Reactive Nitrogen Species Production in Chronic Obstructive Pulmonary Disease Airways

Ichinose, M., Sugiura, H., Yamagata, S., Koarai, A., & Shirato, K. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9908132 · Cited by 347

Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice

Sussan, T. E., Rangasamy, T., Blake, D. J., Malhotra, D., El-Haddad, H., Bedja, D., Yates, M. S., Kombairaju, P., Yamamoto, M., Liby, K. T., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804333106 · Cited by 346

Oxidative Stress Causes Mucin Synthesis Via Transactivation of Epidermal Growth Factor Receptor: Role of Neutrophils

Takeyama, K., Dabbagh, K., Shim, J. J., Dao-Pick, T., Ueki, I. F., & Nadel, J. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.3.1546 · Cited by 346

Environmental toxicity, redox signaling and lung inflammation: The role of glutathione

Biswas, S. K., & Rahman, I. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.07.001 · Cited by 345

T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients

Stefano, A. D., Caramori, G., Gnemmi, I., Contoli, M., Vicari, C., Capelli, A., Magno, F., D’Anna, S. E., Zanini, A., Brun, P., et al. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03965.x · Cited by 343

Impaired Inhibition by Dexamethasone of Cytokine Release by Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease

Culpitt, S. V., Rogers, D. F., Shah, P. L., de Matos, C., Russell, R. E. K., Donnelly, L., & Barnes, P. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200204-298oc · Cited by 337

Lifetime risk of developing chronic obstructive pulmonary disease: a longitudinal population study

Gershon, A. S., Warner, L., Cascagnette, P., Victor, J. C., & To, T. M. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60990-2 · Cited by 329

Impact of oxidative stress on lung diseases

Park, H. S., Kim, S. R., & Lee, Y. C. (2008) · Respirology · doi:10.1111/j.1440-1843.2008.01447.x · Cited by 327

Exhaled Nitric Oxide in Chronic Obstructive Pulmonary Disease

Maziak, W., Loukides, S., Culpitt, S. V., SULLIVAN, P., Kharitonov, S. A., & Barnes, P. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.3.97-05009 · Cited by 323

Transcription factors and asthma

Barnes, P. J., & Adcock, I. M. (1998) · European Respiratory Journal · doi:10.1183/09031936.98.12010221 · Cited by 321

Antioxidant responses to oxidant-mediated lung diseases

COMHAIR, S. A. A., & ERZURUM, S. C. (2002) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00491.2001 · Cited by 307

Reactive Nitrogen Species and Tyrosine Nitration in the Respiratory Tract: Epiphenomena or a Pathobiologic Mechanism of Disease?

van der Vliet, A., Eiserich, J. P., Shigenaga, M. K., & Cross, C. E. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.1.9807044 · Cited by 300

Exhaled Ethane, a Marker of Lipid Peroxidation, is Elevated in Chronic Obstructive Pulmonary Disease

Paredi, P., Kharitonov, S. A., LEAK, D., Ward, S. P., CRAMER, D., & Barnes, P. J. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.2.9909025 · Cited by 298

Oxidation of either methionine super351 or methionine super358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity

Taggart, C. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004850200 · Cited by 297

Glutathione, Stress Responses, and Redox Signaling in Lung Inflammation

Rahman, I., Biswas, S. K., Jimenez, L. A., Torrès, M., & Forman, H. J. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.42 · Cited by 295

Reactive Oxygen Species as Mediators in Asthma

Henricks, P. A. J., & Nijkamp, F. P. (2001) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2001.0319 · Cited by 295

Oxidative Stress, Chromatin Remodeling and Gene Transcription in Inflammation and Chronic Lung Diseases

Rahman, I. (2003) · BMB Reports · doi:10.5483/bmbrep.2003.36.1.095 · Cited by 292

Dietary Antioxidant Vitamin Intake and Lung Function in the General Population

Britton, J. R., Pavord, I. D., Richards, K., Knox, A. J., Wisniewski, A. F. Z., Lewis, S., Tattersfield, A., & Weiss, S. T. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.151.5.7735589 · Cited by 284

Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD

Biernacki, W. (2003) · Thorax · doi:10.1136/thorax.58.4.294 · Cited by 277

Autoimmunity and oxidatively modified autoantigens

Kurien, B. T., & Scofield, R. H. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.04.019 · Cited by 273

Cigarette Smoke–induced Oxidative Stress: A Role in Chronic Obstructive Pulmonary Disease Skeletal Muscle Dysfunction

Barreiro, E., Peinado, V. I., Galdiz, J. B., Ferrer, E., Marin-Corral, J., Sánchez, F., Gea, J., & Barberà, J. A. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200908-1220oc · Cited by 272

Autoantibodies in Patients with Chronic Obstructive Pulmonary Disease

Feghali‐Bostwick, C. A., Gadgil, A. S., Otterbein, L. E., Pilewski, J. M., Stoner, M. W., Csizmadia, E., Zhang, Y., Sciurba, F. C., & Duncan, S. R. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-014oc · Cited by 268

Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: A meta-analysis of published double-blind, placebo-controlled clinical trials

Grandjean, E. M., Berthet, P., Ruffmann, R., & Leuenberger, P. (2000) · Clinical Therapeutics · doi:10.1016/s0149-2918(00)88479-9 · Cited by 267

Enhanced neutrophil response in chronic obstructive pulmonary disease

Noguera, A., Batle, S., Miralles, C., Iglesias, J., Busquets, X., MacNee, W., & Agustí, A. G. N. (2001) · Thorax · doi:10.1136/thorax.56.6.432 · Cited by 266

Antioxidant Nutrients and Pulmonary Function: The Third National Health and Nutrition Examination Survey (NHANES III)

Hu, G., & Cassano, P. A. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010141 · Cited by 260

Accumulation of Dendritic Cells and Increased CCL20 Levels in the Airways of Patients with Chronic Obstructive Pulmonary Disease

Demedts, I., Bracke, K. R., Pottelberge, G. R. V., Testelmans, D., Verleden, G. M., Vermassen, F. E. G., Joos, G., & Brusselle, G. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200608-1113oc · Cited by 258

Chronic Obstructive Pulmonary Disease and Lung Cancer: New Molecular Insights

Adcock, I. M., Caramori, G., & Barnes, P. J. (2011) · Respiration · doi:10.1159/000324601 · Cited by 257

Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review

Poole, P. J., & Black, P. N. (2001) · BMJ · doi:10.1136/bmj.322.7297.1271 · Cited by 256

Oxidative Stress Induces NFκB DNA Binding and Inducible NOS mRNA in Human Epithelial Cells

Adcock, I. M., Brown, C., Kwon, O. J., & Barnes, P. J. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1403 · Cited by 255

Chronic Obstructive Pulmonary Disease Is Associated with an Increase in Urinary Levels of Isoprostane F2 α-III, an Index of Oxidant Stress

Praticò, D., Basili, S., Vieri, M., Cordova, C., Violi, F., & FitzGerald, G. A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.6.9709066 · Cited by 254

Mitochondrial Dysfunction Increases Allergic Airway Inflammation

Aguilera-Aguirre, L., Bácsi, A., Saavedra‐Molina, A., Kurosky, A., Sur, S. A., & Boldogh, I. R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900228 · Cited by 251

Oxidative Stress and Respiratory Muscle Dysfunction in Severe Chronic Obstructive Pulmonary Disease

Barreiro, E., de la Puente, B., Minguella, J., Corominas, J. M., Serrano, S., Hussain, S. N. A., & Gea, J. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-887oc · Cited by 244

Nrf2 protects against airway disorders

Cho, H., & Kleeberger, S. R. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.07.024 · Cited by 238

Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite

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Defective Phagocytosis in Airways Disease

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