Cited by 44Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

Efferocytosis Creates a Tumor Microenvironment Supportive of Tumor Survival and Metastasis

Open access
David Vaught, Jamie C. Stanford, Rebecca S. Cook·2015·Cancer Cell & Microenvironment

Abstract

Programmed cell death, or apoptosis, occurs in nearly all tissues of all multi-cellular organisms. In order to avoid leakage of intracellular contents, which could generate tissue damaging inflammation, apoptotic cells are cleared from tissues by phagocytes, which then dispatch the engulfed dying cell through the lysosomal pathway. Phagocytic clearance of apoptotic cells is referred to as efferocytosis. One key feature of efferocytosis is the production and release of wound healing cytokines by the phagocyte, which acts to resolve inflammation, and promote tissue repair. Phagocytic engulfment of apoptotic cells coupled with cytokine modulation aimed at immune suppression ensures that physiological programmed cell death does not induce inflammation and tissue damage. However, cytokines involved in wound healing and immune suppression are notorious for their role in the tumor microenvironment, increasing tumor cell motility and promoting evasion of anti-tumor immunity. Therefore, current and future studies aimed at targeting important players of efferocytosis should reveal new and efficacious therapeutic approaches for limiting cancer progression and relapse.

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Crossref · 10.14800/ccm.666

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  • Efferocytosis is seen as a major hurdle to using antigen presenting cells in cell-based therapies.

    “It is seen as a major hurdle to using antigen presenting cells in cell-based therapies (61–64).”

    From Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells (2026) · cites this paper as [62]

    The Introduction (page not provided) says efferocytosis causes antigen-presenting macrophages to promote immune tolerance and suppress adaptive immune responses. It does not describe efferocytosis as a major hurdle to using antigen-presenting cells in cell-based therapies; that application and degree of difficulty are unsupported. (LLM, conf=0.78)

    Experimental — accuracy not yet measured

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Authors
Vaught, D., Stanford, J. C., & Cook, R. S.
Affiliations
Vanderbilt University (US)
Venue
Cancer Cell & Microenvironment
Published
2015-03-18
Volume
2
Issue
1
ISSN
  • 2331-091X (ISSN-L)
  • 2331-0928
OpenAlex
W1666037483
Cited by
44
References
114
Citations by year
2026: 4 · 2025: 6 · 2024: 2 · 2023: 5 · 2022: 9 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 1
FWCI
0.66
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell & Microenvironment (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Cancer Institute (R01CA143126, T32CA009592)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
efferocytosis, tumor microenvironment, apoptosis, phagocytes, immunosuppression, metastasis, tumor cell motility, cancer therapy targets

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