Cited by 1,032Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysMitochondrial Function and Pathology

The DOI matches its Crossref record; 160 of the 166 references it cites were found in a registry or an index.

Mitophagy: mechanisms, pathophysiological roles, and analysis

Open access

Ding, Wen-Xing, Yin, Xiao-Ming·2012·bchm

DOI 10.1515/hsz-2012-0119PMC PMC3630798

Open this paper in CoChat — free account Open PDF

Abstract

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury. Removal of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic recognition. Recent progress in mitophagy studies reveals that mitochondrial priming is mediated either by the Pink1-Parkin signaling pathway or the mitophagic receptors Nix and Bnip3. In this review, we summarize our current knowledge on the mechanisms of mitophagy. We also discuss the pathophysiological roles of mitophagy and current assays used to monitor mitophagy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1515/hsz-2012-0119

Cites

160 of 160 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., & Semenza, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800102200 · Cited by 1,601
Retracted
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Autophagy: process and functionPreprint
Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 4,104
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

Flagged first, then by citations

Show all 166 references

6 of the 166 references couldn’t be matched to a known paper.

Sorted by citations

Items 901–1,000 of 1,001

The influence of aging on oocyte quality and the importance of mitochondria
Trull, K. (2014) · Digital Repository Service (Northeastern University) · doi:10.17760/d20005089
Human skeletal muscle mitochondria: Changes with aging and role in sarcopenia
Distéfano, G. (2015) · D-Scholarship@Pitt (University of Pittsburgh)
Regulation of postnatal skeletal muscle growth and metabolism by peroxisome proliferator-activated receptor??/??
Chandrashekar, P. (2016) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/67320
Role of mitochondrial hexokinase-ii dissociation in the induction of mitophagy in cardiomyocytes
Ding, E. (2014) · eScholarship (California Digital Library)
Autophagy-linked FYVE protein mediates the turnover of mutant huntingtin and modifies pathogenesis in mouse models of Huntington’s disease
Fox, L. M. (2016) · doi:10.7916/d83b60cm
Vinyl chloride-diet interactions in liver disease : potential roles of autophagy and energy management.
Lang, A. L. (2016) · doi:10.18297/etd/2529
The Effects of Autophagic Deficiencies on the Leukemia Mitochondrial Phenotype and Implications in Strategic Drug Targeting
Rodrigo, R. (2016) · UWSpace (University of Waterloo)
Aluminium Adjuvants – a Nanomaterial used as Adjuvants in Human Vaccines for Decades
Eriksson, H., Sandberg, T., & Danielsson, R. (2017) · Current Bionanotechnology · doi:10.2174/2213529403666170310143243 · Cited by 1
Novel Therapeutic Approaches to Induce Autophagy in Brain Cancer
Conway, G. E. (2016) · Arrow - TU Dublin (Technological University Dublin) · doi:10.21427/d7632v
Regulation of Mitochondrial Fission by Ceramide-induced Bcl-2-related Ovarian Killer in Preeclampsia
Ausman, J. (2017) · TSpace (University of Toronto)
New mechanisms in cancer metastasis : tumor-endothelial contact-induced angiogenesis and autophagy in the progression of distant metastases
Chiew, G. G. Y. (2017) · doi:10.32657/10356/72070
Regulation of mitochondrial and nonmitochondrial protein turnover by the PINK1-Parkin pathway
Vincow, E. S. (2013) · ResearchWorks at the University of Washington (University of Washington)
Life and Death of Cytochrome c Oxidase: Influence of Subunit III on the D pathway, Proton Backflow and Suicide Inactivation
Ferguson-Miller, S. M., & Hosler, J. P. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781788010405-00215
Análise da via autofágica no músculo distrófico
Fernandes, S. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.41.2017.tde-17102017-161008
Effect of Lipotoxicity on ER Stress, Autophagy and Apoptosis in Skeletal Muscle and Regulation by Adiponectin
Priyanka, E. (2014) · YorkSpace (York University)
Role of autophagy in GM1-mediated neuroprotection in Huntington's Disease
Schmelz, S. (2016) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3sj1b59m
Estudio de la mitofagia en respuesta a un programa de entrenamiento de fuerza en personas mayores = Study of mitophagy in response to a strength training program for older people
Moreira, O. C. (2018) · Buleria (Universidad de León) · doi:10.18002/10612/8008
MITOCHONDRIAL OXIDATIVE STRESS AND BIOGENESIS DURING ACETAMINOPHEN HEPATOTOXICITY
Du, K. (2017) · KU ScholarWorks (The University of Kansas)
Characterization of the Mitochondrial Peptide Pβ
Tan, W. G. (2018) · TSpace (University of Toronto)
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
Wei, C.-W., Zhou, T.-A., Dzhagalov, I. L., & Hsu, C. (2019) · Journal of Visualized Experiments · doi:10.3791/58844
The Role of Nrf2 Signalling in Cell Proliferation and Tumorigenesis of Chromium Transformed Human Bronchial Epithelial Cells
Clementino, M. (2019) · UKnowledge (University of Kentucky) · doi:10.13023/etd.2019.047
SAT0050 TNF-α INDUCES MITOPHAGY FORMATION IN RHEUMATOID ARTHRITIS SYNOVIAL FIBROBLAST AND INHIBITION OF MITOPHAGY AMELIORATES SYNOVITIS IN COLLAGEN ANTIBODY-INDUCED ARTHRITIS
Jung, Y. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-eular.4641
SAT0052 PHOTODYNAMIC THERAPY TARGETING ACTIVATED FIBROBLASTS INDUCES SYNOVIAL CELL DEATH IN EXPERIMENTAL ARTHRITIS
Dorst, D. N., Rijpkema, M., Buitinga, M., Laverman, P., Boss, M., Klein, C., Freimoser–Grundschober, A., Walgreen, B., van der Kraan, P. M., Gotthardt, M., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2019-eular.7252
Controlled release of the histone deacetylase inhibitor sodium butyrate for increasing recombinant protein production /
McCabe, C. (2019) · Research@THEA
Obesity-induced hepatic changes during pregnancy
Grilo, L. F. (2019) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)
Molecular Mechanisms Underlying the Role of Mitophagy in Neurodegeneration
Ahlawat, A., Kaira, M., Walia, V., & Garg, M. (2020) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-7998-1317-0.ch003
The Effect of Apilarnil on The Autophagia Against Lipolysaccarite-Based Sepsıs in Liver
Doğanyiğit, Z., Köklü, B., Üner, A. K., Okan, A., Kaymak, E., & Sılıcı, S. (2020) · DergiPark (Istanbul University)
Heat Shock Protein 72 Regulation of Metabolism
Archer, A. E. (2018) · KU ScholarWorks (The University of Kansas)
Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer
Craig, J. (2020) · doi:10.21007/etd.cghs.2020.0512
Mitochondrial Biogenesis, Mitophagy, and Mitophagic Cell Death in Cancer Regulation: A Comprehensive Review
Praharaj, P. P., Behera, B. P., Mishra, S. R., Patra, S., Mahapatra, K. K., Panigrahi, D. P., Bhol, C. S., & Bhutia, S. K. (2020) · Springer eBooks · doi:10.1007/978-981-15-6930-2_7
Targeting Alzheimer's disease neuronal mitochondria as a therapeutic approach
Onyango, I. G., & Stokin, G. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819621-2.00015-2
Mitochondria transplantation in organ damage and repair
Rossi, A., Porporato, P. E., & Bussolati, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819451-5.00001-9
Mitochondrial dysfunction in skin and ocular surface disease: an interdisciplinary review
Memar, O. M. (2019) · Journal of Dermatology & Cosmetology · doi:10.15406/jdc.2019.03.00118
Muscle mitochondrial health : ageing, physical activity and molecular mechanisms
Lagerwaard, B. (2021) · doi:10.18174/537712
Role of Extracellular Vesicles in Neuroinflammatory Progression and Mitochondrial Functional Alterations
Russell, A. E. (2019) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.3947
Mecanismos moleculares envolvidos na redução da funcionalidade mitocondrial e autofagia do tecido adiposo marrom de ratos alimentados com dieta hiperproteica
da Silva, K. E. (2020) · doi:10.11606/d.17.2020.tde-07042021-144123
Fiddle Songs and Banjo Songs: A Description Index
Howard, G. W. (1981) · TopSCHOLAR (Western Kentucky University)
Investigating the relationship between Ambra1, Autophagy and Cell proliferation in Melanoma
Ibrahim, M. (2021) · Sunderland Repository (University of Sunderland)
Updates on mitochondria, calorie restriction, and aging
Yousefsani, B. S., Dadmehr, M., & Pourahmad, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822416-8.00005-1
Axotomy induce an increase in the expression of Pink1, Parkin and Сofilin in rat dorsal root ganglia
Pitinova, M., Kalyuzhnaya, Y. N., & Demyanenko, S. V. (2022) · Saratov Fall Meeting: Optical and Nanotechnologies for Biology and Medicine (SFM) · doi:10.1117/12.2623566
Potencial terapêutico das células-tronco mesenquimais na doença renal diabética é mediado pelo efeito antioxidante e modulador no programa de controle de qualidade mitocondrial
Silva, C. (2020) · doi:10.31744/pg2020.106863
Dietary restriction and mTOR and IIS inhibition: the potential to antiaging drug approach
Tsou, S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90235-9.00003-3
The role of hepatic mitochondrial function and mitochondrial turnover in the development and progression of nonalcoholic fatty liver disease and lifestyle modifications to treat the disease
Moore, M. P. (2021) · MOspace Institutional Repository (University of Missouri) · doi:10.32469/10355/91011
Tea polyphenols stimulate mt bioenergetics in cardiometabolic diseases
Srividhya, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-90256-4.00012-6
Autophagy in Embryonic Stem Cells and Neural Stem Cells
Puri, D., Bivalkar-Mehla, S., & Subramanyam, D. (2022) · Stem cell biology and regenerative medicine · doi:10.1007/978-3-031-17362-2_3
Receptores LXR e seu papel na modulação do metabolismo e função de macrófagos residentes do tecido adiposo: uma nova ferramenta para o tratamento de doenças metabólicas
Pereira, J. A. D. S. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2022.tde-06052022-145847
Donut and spheroid mitochondria: eating, regenerating or trash them out?
Ding, W., & Shen, H. (2023) · Life Metabolism · doi:10.1093/lifemeta/load008
Self-citation
ผลการปกปองของสารสกดใบรางจดจากการเหนยวนำความเปนพษดวยกลตาเมตในเซลลประสาท HT-22 ผานวถออโตฟาจ
วงศ์ทิพย์, ว. (2019) · doi:10.58837/chula.the.2019.785
RETRACTED: Investigation of Mitophagy Relation Genes Expression in Mice Fed a High-Fat Diet and ExercisedPreprint
Durak, Ş., Sezgin, S. B. A., Çelik, F., Yılmazer, Y., Çevik, A., Küçükhüseyin, Ö., Yaylım, İ., & Zeybek, Ü. (2023) · Research Square · doi:10.21203/rs.3.rs-3792150/v1
Retracted
Nutritional programming of white adipose tissue and mitochondrial function : Fat quality matters
Kodde, F. D. (2024) · doi:10.18174/644648
Additional file 5 of Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity
Fu, W., Cao, X., An, T., Zhao, H., Zhang, J., Li, D., Jin, X., & Liu, B. (2022) · Figshare · doi:10.6084/m9.figshare.20329465
Additional file 3 of Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity
Fu, W., Cao, X., An, T., Zhao, H., Zhang, J., Li, D., Jin, X., & Liu, B. (2022) · Figshare · doi:10.6084/m9.figshare.20329459
Additional file 2 of Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity
Fu, W., Cao, X., An, T., Zhao, H., Zhang, J., Li, D., Jin, X., & Liu, B. (2022) · Figshare · doi:10.6084/m9.figshare.20329456
The Application of Framework Nucleic Acid‐Based Nanomaterials in the Treatment of Mitochondrial Dysfunction
Yao, L., & Zhang, T. (2024) · Wiley eBooks · doi:10.1002/9783527841912.ch4
Güncel Biyokimya Çalışmaları VII
Atıcı, Y., Ökten, Z., Kasebi, S., Arıkan, B. S., Erdem, M., Kıran, T. R., Yağız, A. K., Aktolun, B., Demirağcı, Y. G., Kara, H., et al. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3109
Protein Restriction in Aging and Disease
Brandhorst, S. (2024) · Springer eBooks · doi:10.1007/978-3-031-49622-6_2
Bioinformatics and Machine Learning-Based Screening of Key Genes in Alzheimer's Disease
Hou, M., Bao, J., Zheng, S. X., Li, S. T., & Li, X. (2024) · International Journal of Web Services Research · doi:10.4018/ijwsr.349590
Cancer and mitochondrial transplantation, and novel insights into its application in the cancer-like phenotype of pulmonary arterial hypertension
Sanni, O., Payne, C., & Maarman, G. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18858-9.00021-4
Both Splice Variants of Zebrafish Tmem11 Localize to the Outer Membrane of Mitochondria
Tadesse, S. S., Schille, M. E., Cordon, P. C., & Walsh, S. (2024) · PubMed Central · doi:10.17912/micropub.biology.001162
Role of individual structural and functional elements of myelin in Parkinson’s disease
Shulskaya, M. V., Slominsky, P. A., Shadrina, M. I., & Alieva, A. K. (2024) · Журнал высшей нервной деятельности им И П Павлова · doi:10.31857/s0044467724030011
Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis
Ma, X., Zhang, C., & Ding, W. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15260-3.00016-8
Self-citation
The aging brain, mitochondria, and neurodegenerative disorders
Amin, S. N., Alhanaktah, B., Mohd, O. B., & ShamsEldeen, A. M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15702-8.00003-8
Myelin Genes Whose Expression Is Linked with Parkinson’s Disease
Shulskaya, M. V., Slominsky, P. A., Shadrina, M. I., & Alieva, A. K. (2024) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-024-01733-4
Reviewer #1 (Public review): The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism
(2025) · eLife · doi:10.7554/elife.105541.1.sa2
Hormesis-induced neuroplasticity: Targeting neuroinflammation signaling cascades for therapeutic insights in aging and neurodegenerative diseases
Santiago, T. C., & Scavone, C. (2025) · Progress in brain research · doi:10.1016/bs.pbr.2025.05.008
PLEKHF1 Induces Mitochondrial Dysfunction to Inhibit Osteosarcoma Growth and Metastasis
Wan, J., Cai, X., Liao, Z., Liu, Y., Liu, Q., Zhang, C., & Long, F. (2025) · IUBMB Life · doi:10.1002/iub.70048
Chronic administration of the hydrogen sulfide prodrug SG1002 partially protects against erectile dysfunction resulting from long-term androgen deprivation
Ihrig, C. M., Pierre, C. J., Azeez, T. A., & Favor, J. D. L. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123976
The RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolismPreprint
Lapão, A., Johnson, L. S., Trachsel-Moncho, L., Rodgers, S. J., Singh, S., Ng, M. Y. W., Nakken, S., Eskelinen, E., & Simonsen, A. (2025) · eLife · doi:10.7554/elife.105541.2
Sex- and age-differences in cellular hallmarks of aging in a species with female-biased longevity and environmental sex determinationPreprint
Marks, J. R., Janzen, F. J., Reinke, B. A., Addis, E. A., Adesioye, O., Bock, S. L., Clark, M. A., Crowther, C., Hoekstra, L. A., Judson, J. M., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.10.693506
Additional file 1 of Ginkgolide B inhibits lung cancer cells promotion via beclin-1-dependent autophagy
Wang, X., Shao, Q.-H., Zhou, H., 吴军录, 权文强, Ji, P., 姚懿雯, Li, D., & Sun, Z.-J. (2020) · Figshare · doi:10.6084/m9.figshare.12552686
Additional file 1 of Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease
Li, C., Liu, Q., Chang, Q., Xie, M., Weng, J., Wang, X., Li, M., Chen, J., Huang, Y., Yang, X., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24864159
Additional file 1 of Liver metabolomics reveals potential mechanism of Jieduan-Niwan formula against acute-on-chronic liver failure (ACLF) by improving mitochondrial damage and TCA cycle
Liang, J., Wei, X., Hou, W., Wang, H., Ma, R., Gao, Y., Du, Y., & Zhang, Q. (2024) · Figshare · doi:10.6084/m9.figshare.26647884
Additional file 2 of Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion
Liu, Q., Weng, J., Li, C., Feng, Y., Xie, M., Wang, X., Chang, Q., Li, M., Chung, K. F., Adcock, I. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706929
Additional file 1 of Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity
Fu, W., Cao, X., An, T., Zhao, H., Zhang, J., Li, D., Jin, X., & Liu, B. (2022) · Figshare · doi:10.6084/m9.figshare.20329453
Additional file 1 of Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells
Krajčová, A., Skagen, C., Džupa, V., Urban, T., Rustan, A. C., Jiroutková, K., Bakalář, B., Thoresen, G. H., & Duška, F. (2022) · Figshare · doi:10.6084/m9.figshare.21522070
Additional file 1 of The economics of organellar gene loss and endosymbiotic gene transfer
Kelly, S. (2021) · Figshare · doi:10.6084/m9.figshare.17304771
Additional file 2 of Ginkgolide B inhibits lung cancer cells promotion via beclin-1-dependent autophagy
Wang, X., Shao, Q.-H., Zhou, H., 吴军录, 权文强, Ji, P., 姚懿雯, Li, D., & Sun, Z. (2020) · Figshare · doi:10.6084/m9.figshare.12552695
Additional file 4 of Genome-wide identification of resistance genes and transcriptome regulation in yeast to accommodate ammonium toxicity
Fu, W., Cao, X., An, T., Zhao, H., Zhang, J., Li, D., Jin, X., & Liu, B. (2022) · Figshare · doi:10.6084/m9.figshare.20329462
Additional file 1 of Attenuation of PM2.5-induced alveolar epithelial cells and lung injury through regulation of mitochondrial fission and fusion
Liu, Q., Weng, J., Li, C., Feng, Y., Xie, M., Wang, X., Chang, Q., Li, M., Chung, K. F., Adcock, I. M., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23706926
Additional file 7 of The economics of organellar gene loss and endosymbiotic gene transfer
Kelly, S. (2021) · Figshare · doi:10.6084/m9.figshare.17304792
The potential of phytochemicals in mitophagy-driven treatment of metabolic diseases
Banerjee, A., Banerjee, S., & Singh, A. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-31698-2.00009-6
βラクタム系の抗菌薬であるアモキシシリンは、ミトコンドリアに影響しがん細胞のシスプラチン感受性を増強する
Takami, Y. (2025) · Kagoshima University Repository
An elementary model of homeostasis and immunity that generates symbiosisPreprint
Eberl, G. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.15.695950
Understanding liver and digestive diseases: a paved road to improve diagnosis, management, and treatment
Bergheim, I., Cadranel, J. F. D., Chen, J., Ding, W., Eferl, R., García‐Ruiz, C., Jaeschke, H., Kazerouni, F., Lonardo, A., Mann, D. A., et al. (2026) · Exploration of Digestive Diseases · doi:10.37349/edd.2026.1005110
Self-citation
Mitochondrial-Endoplasmic Reticulum Axis (MERA) in Pulmonary Hypertension
Bai, J., Sun, H., Huang, C., Bai, D., Zhu, J., Yang, L., Bao, C., Liang, S., Wang, Q., Wang, Y.-X., et al. (2026) · Springer eBooks · doi:10.1007/978-3-031-55254-0_29-1
Mitochondrial–nuclear crosstalk and its role in cancer
Vliora, M., & Καλτσάτου, Α. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40535-8.00021-1
Metabolic axis of autophagy: A key player in tumor maintenance and opportunities for therapeutic exploitation
Garg, M. (2026) · World Journal of Clinical Oncology · doi:10.5306/wjco.v17.i3.115094
AATF supports proliferation of glioblastoma cells by sustaining mitochondrial respiration through an NRF-1-dependent mechanism
Sorino, C., Giovenale, S. D., Falcone, I., Auciello, F. R., Pulito, C., Sardo, F. L., Scalera, S., Nicola, F. D., Catena, V., Ciuffreda, L., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08617-0
Implication of mitochondria endoplasmic-reticulum interactions in the control of hepatic metabolism
Theurey, P. (2015) · theses.fr (ABES) · doi:10.70675/c827066dz5c76z4f0azb465z409dc90bb0e5
Analyse du mécanisme et du rôle de l'inhibition de l'autophagie par deux protéines complémentaires du cytomégalovirus humain
Mouna, L. (2015) · theses.fr (ABES) · doi:10.70675/1dc124dez24f3z4b44z9ad2z25779481814f
Étude de la dynamique mitochondriale dans des cellules cutanées humaines : Mise en place de modèles pour des applications en cosmétologie
Jugé, R. (2016) · theses.fr (ABES) · doi:10.70675/9292bf9bz12caz4c3az8bdaz1397a0351584
Étude des modifications sub-cellulaires associées au vieillissement musculaire chez Caenorhabditis elegans-Rôle du facteur de transcription UNC-120/SRF
Lamarche, A. M. D. (2016) · theses.fr (ABES) · doi:10.70675/9ce6267dz94c3z4e2ez8a69z5f6b5ac9b808
Une nouvelle mutation du collagène V conduisant, chez le patient, à des atteintes cutanées et musculaires
Badara, S. N. (2016) · theses.fr (ABES) · doi:10.70675/4c7f6348zf660z439cz836fz8324fff72f95
Etude de la dysfonction cellulaire et moléculaire du syndrome mitochondrial MELAS.
Geffroy, G. (2017) · theses.fr (ABES) · doi:10.70675/a2ae3815zb7a8z4cbcz9a2dz22dbcd055adb
Rôles du stress oxydant et de ses dérivés dans les mécanismes physiopathologiques de l’insuffisance cardiaque
Santin, Y. (2019) · theses.fr (ABES) · doi:10.70675/6d1ffd1dz8c9dz41e9z9369z790c21447a0f
Modulation de l'autophagie des macrophages : rôle des lipides de l'enveloppe
Bah, A. (2017) · theses.fr (ABES) · doi:10.70675/0170380fz0af5z4c02za7aezd5ac5153ffd8
PGC-1α régule un programme onco-métabolique capable de réprimer l’agressivité du cancer de la prostate
Kaminski, L. (2018) · theses.fr (ABES) · doi:10.70675/7f6ae88bz4f3cz49d3zafcdz8682254b2be3
Le donneur de rein décédé, principes physiopathologiques et innovations thérapeutiques
Kerforne, T. (2018) · theses.fr (ABES) · doi:10.70675/f25441cfz0e1bz40f5zbae0z0ea1d0037f9f
Phénotypes et endotypes de l'asthme sévère préscolaire de l’enfant : rôle du muscle lisse bronchique dans le remodelage précoce
Siao-Him-Fa, V. (2018) · theses.fr (ABES) · doi:10.70675/1b0e6d94z9f98z4cb1za25ezc5d2f59d2e4f
Détection et quantification de l'ADN circulant : conditions pré-analytiques et applications pour le suivi des patients atteints de cancer colorectal
Meddeb, R. (2019) · theses.fr (ABES) · doi:10.70675/43aaefbdz9b84z4530z9f7az31734d0d3d36

Authors: Ding, W.-X., & Yin, X.-M.
Affiliations: University of Kansas Medical Center (US)
Indiana University School of Medicine (US)
ORCID: Ding, Wen-Xing
Yin, Xiao-Ming
Venue: bchm
Publisher: Walter de Gruyter GmbH
Published: 2012-07-01
Volume: 393
Issue: 7
Pages: 547-564
ISSN: 1431-6730 (ISSN-L)
1437-4315
DOI: 10.1515/hsz-2012-0119
PMC: PMC3630798
OpenAlex: W2076769172
Cited by: 1,032
References: 166
Citations by year: 2026: 47 · 2025: 77 · 2024: 83 · 2023: 99 · 2022: 90 · 2021: 115 · 2020: 111 · 2019: 98 · 2018: 67 · 2017: 64 · 2016: 59 · 2015: 44 · 2014: 50 · 2013: 25 · 2012: 1
FWCI: 4.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biological Chemistry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: National Institutes of Health (AA020518, RR016475)
National Institute on Alcohol Abuse and Alcoholism (R01AA020518, R21AA017421, R37AA020518)
National Cancer Institute (R01CA83817, R01CA083817)
National Institute of General Medical Sciences (P20GM103418)
National Center for Research Resources (P20RR021940, RR016475, P20RR016475)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitophagy, PINK1/Parkin pathway, Nix, BNIP3, mitochondrial priming, selective autophagy, neurodegenerative diseases, ischemia, energy homeostasis, cell death
MeSH terms: Aging, Animals, Disease, Humans, Mitochondria, Signal Transduction, Mitochondrial Proteins, Mitophagy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitophagy: mechanisms, pathophysiological roles, and analysis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks