Cited by 1,032Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysMitochondrial Function and Pathology

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Mitophagy: mechanisms, pathophysiological roles, and analysis

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Ding, Wen-Xing, Yin, Xiao-Ming·2012·bchm

DOI 10.1515/hsz-2012-0119PMC PMC3630798

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Abstract

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury. Removal of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic recognition. Recent progress in mitophagy studies reveals that mitochondrial priming is mediated either by the Pink1-Parkin signaling pathway or the mitophagic receptors Nix and Bnip3. In this review, we summarize our current knowledge on the mechanisms of mitophagy. We also discuss the pathophysiological roles of mitophagy and current assays used to monitor mitophagy.

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Authors: Ding, W.-X., & Yin, X.-M.
Affiliations: University of Kansas Medical Center (US)
Indiana University School of Medicine (US)
ORCID: Ding, Wen-Xing
Yin, Xiao-Ming
Venue: bchm
Publisher: Walter de Gruyter GmbH
Published: 2012-07-01
Volume: 393
Issue: 7
Pages: 547-564
ISSN: 1431-6730 (ISSN-L)
1437-4315
DOI: 10.1515/hsz-2012-0119
PMC: PMC3630798
OpenAlex: W2076769172
Cited by: 1,032
References: 166
Citations by year: 2026: 47 · 2025: 77 · 2024: 83 · 2023: 99 · 2022: 90 · 2021: 115 · 2020: 111 · 2019: 98 · 2018: 67 · 2017: 64 · 2016: 59 · 2015: 44 · 2014: 50 · 2013: 25 · 2012: 1
FWCI: 4.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biological Chemistry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: National Institutes of Health (AA020518, RR016475)
National Institute on Alcohol Abuse and Alcoholism (R01AA020518, R21AA017421, R37AA020518)
National Cancer Institute (R01CA83817, R01CA083817)
National Institute of General Medical Sciences (P20GM103418)
National Center for Research Resources (P20RR021940, RR016475, P20RR016475)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitophagy, PINK1/Parkin pathway, Nix, BNIP3, mitochondrial priming, selective autophagy, neurodegenerative diseases, ischemia, energy homeostasis, cell death
MeSH terms: Aging, Animals, Disease, Humans, Mitochondria, Signal Transduction, Mitochondrial Proteins, Mitophagy

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