Cited by 1,032Autophagy in Disease and TherapyUbiquitin and proteasome pathwaysMitochondrial Function and Pathology

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Mitophagy: mechanisms, pathophysiological roles, and analysis

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Ding, Wen-Xing, Yin, Xiao-Ming·2012·bchm

DOI 10.1515/hsz-2012-0119PMC PMC3630798

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Abstract

Mitochondria are essential organelles that regulate cellular energy homeostasis and cell death. The removal of damaged mitochondria through autophagy, a process called mitophagy, is thus critical for maintaining proper cellular functions. Indeed, mitophagy has been recently proposed to play critical roles in terminal differentiation of red blood cells, paternal mitochondrial degradation, neurodegenerative diseases, and ischemia or drug-induced tissue injury. Removal of damaged mitochondria through autophagy requires two steps: induction of general autophagy and priming of damaged mitochondria for selective autophagic recognition. Recent progress in mitophagy studies reveals that mitochondrial priming is mediated either by the Pink1-Parkin signaling pathway or the mitophagic receptors Nix and Bnip3. In this review, we summarize our current knowledge on the mechanisms of mitophagy. We also discuss the pathophysiological roles of mitophagy and current assays used to monitor mitophagy.

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1 retracted

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., & Semenza, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800102200 · Cited by 1,601
Retracted
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,615
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Autophagy: process and functionPreprint
Mizushima, N. (2007) · Genes & Development · doi:10.1101/gad.1599207 · Cited by 4,104
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026
Autophagy regulates lipid metabolism
Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

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RETRACTED: Guidelines for the role of autophagy in drug delivery vectors uptake pathways
Dowaidar, M. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30238 · Cited by 5
Retracted
Mitochondrial DNA Instability Supersedes Parkin Mutations in Driving Mitochondrial Proteomic Alterations and Functional Deficits in Polg Mutator Mice
Trease, A. J., Totusek, S., Lichter, E. Z., Stauch, K. L., & Fox, H. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126441 · Cited by 5
Alpha-Asarone attenuates alcohol-induced hepatotoxicity in a murine model by ameliorating oxidative stress, inflammation, and modulating apoptotic-Autophagic cell death
Ali, N. A. M., Abdelhamid, A. M., El-Sayed, N. M., & Radwan, A. M. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.117041 · Cited by 5
Mitochondrial dynamics in Angiostrongylus cantonensis-infected mouse brain
Lam, H. Y. P., Chen, C.-C., Chen, T. T.-W., Chang, K.-C., Wu, W.-J., Yang, T.-H., Liang, T.-R., Cheng, P.-C., & Peng, S.-Y. (2020) · Parasitology International · doi:10.1016/j.parint.2020.102231 · Cited by 5
[Effect of cordycepin on apoptosis and autophagy of tongue cancer cells in vitro and the molecular mechanism].
Zheng, Q., Gao, S., Lv, J., Chen, D., Chen, J., Li, H., & Guan, J. (2018) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-4254.2018.04.04 · Cited by 5
H2S alleviates Parkinson-like phenotypes by modulating lncRNA-CasC7/miR-30c/BNIP3L signaling pathway
Long, L., Cai, X., Liao, J., Ma, X., Liu, Y., Huang, Y., Liu, X., & Chen, X. (2021) · Archives of Medical Science · doi:10.5114/aoms/114038 · Cited by 5
Targeting cellular batteries for the therapy of neurological diseases
Arora, A., Behl, T., Sehgal, A., Singh, S., Sharma, N., Mathew, B., & BUNGAU, S. G. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14665-0 · Cited by 5
Adult and Cancer Stem Cells: Perspectives on Autophagic Fate Determinations and Molecular Intervention
Chen, K. G., & Calderone, R. (2016) · Current cancer research · doi:10.1007/978-3-319-42740-9_6 · Cited by 5
Silencing of PCK1 mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission
Zhang, L., Chen, Y., Pan, Q., Fang, S., Zhang, Z., Wang, J., Yang, Y., Yang, D., & Sun, X. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024154 · Cited by 4
Amoxicillin, a β-lactam antibiotic, enhances cisplatin sensitivity in cancer cells affecting mitochondria
Takami, Y., Tomita, K., Igarashi, K., Kuwahara, Y., Kitanaka, J., Kitanaka, N., Roudkenar, M. H., Roushandeh, A. M., Saijo, H., Kurimasa, A., et al. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.151888 · Cited by 4
CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation
Fu, S., Nie, Y., Ping, P., Gao, Z., Zhao, Y., Wang, W., Li, Z., & Liu, Q. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003757 · Cited by 4
Super-Resolution Imaging Captures Mitophagy Dynamics: Tricolor Fluorescence Labels Mitochondria, Autophagosomes, and Lysosomes
Peng, W., Li, M., Li, W., Wang, Y., Tian, C., Zhao, Z., Gao, M., & Yang, L. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c03247 · Cited by 4
Hazards related to the presence of paracetamol in the environment – ultrastructural analysis of the midgut epithelium of tardigrade Hypsibius exemplaris (Eutardigrada, Hypsibiidae)
Wieczorkiewicz, F., Sojka, J., Arslan, A., Krakowska, A., Kowalska, M., & Poprawa, I. (2025) · Aquatic Toxicology · doi:10.1016/j.aquatox.2025.107597 · Cited by 4
The Metabolic Heart: Reframing Heart Failure With Preserved Ejection Fraction as a Systemic Cardio-Metabolic Syndrome
Baidya, D., Kshatri, A. H. S., Zerzan, E. K., Menon, G. J., Sawale, M., & Bhalodiya, S. S. (2026) · Cureus · doi:10.7759/cureus.100590 · Cited by 4
Crosstalk Between Autophagy and Paraptosis: A New Frontier in Cancer Therapy
Hanson, S., Murugan, D., Jinsha, P. V., Binoy, A., Nair, B. G., & Mishra, N. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052234 · Cited by 4
Distribution and Localization of Mahogunin Ring Finger 1 in the Mouse Central Nervous System
Nakadate, K., & Kawakami, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168956 · Cited by 4
NRF-2α and mitophagy underlie enhanced mitochondrial functions and biogenesis induced by T-2 toxin in GH3 cells
Guo, J., Ye, X., Zhao, Y., Huang, D., Wu, Q., Ihsan, A., & Wang, X. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113687 · Cited by 4
The conserved cellular roles of CLN proteins: Novel insights from Dictyostelium discoideum
Remtulla, A. A. N., & Huber, R. J. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151305 · Cited by 4
Silver nanoparticles affect bidirectional crosstalk between mitochondria and lysosomes in hemocyte subtypes of the oyster Crassostrea hongkongensis
Luo, Y., & Wang, W. (2023) · Environmental Science Nano · doi:10.1039/d3en00181d · Cited by 4
Knockdown of mitochondrial sirtuin sir-2.2 reduces alpha-synuclein clearance and impairs energy homeostasis in a model of ageing
Naseer, A., Toppo, P., Akbar, M., & Nazir, A. (2025) · Disease Models & Mechanisms · doi:10.1242/dmm.052197 · Cited by 4
Continuous treatment with FTS confers resistance to apoptosis and affects autophagy
Schmukler, E., Wolfson, E., Elazar, Z., Kloog, Y., & Pinkas‐Kramarski, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171351 · Cited by 4
Quality Control Mechanisms of Mitochondria: Another Important Target for Treatment of Peripheral Neuropathy
Zhang, T., Li, J., & Zhao, G. (2021) · DNA and Cell Biology · doi:10.1089/dna.2021.0529 · Cited by 4
The Complex Crosstalk Between Autophagy and ROS Signalling Pathways
Airiau, K., & Djavaheri‐Mergny, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-30079-5_3 · Cited by 4
Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice
Li, B., Yang, S., Ye, J.-R., Chu, S., Chen, N., & An, Z. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136222 · Cited by 4
Ginsenoside Rg1 improves ischemic brain injury by balancing mitochondrial biogenesis and mitophagy
Tang, X., Chen, N., & Long, X. (2017) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v16i10.22 · Cited by 4

Authors: Ding, W.-X., & Yin, X.-M.
Affiliations: University of Kansas Medical Center (US)
Indiana University School of Medicine (US)
ORCID: Ding, Wen-Xing
Yin, Xiao-Ming
Venue: bchm
Publisher: Walter de Gruyter GmbH
Published: 2012-07-01
Volume: 393
Issue: 7
Pages: 547-564
ISSN: 1431-6730 (ISSN-L)
1437-4315
DOI: 10.1515/hsz-2012-0119
PMC: PMC3630798
OpenAlex: W2076769172
Cited by: 1,032
References: 166
Citations by year: 2026: 47 · 2025: 77 · 2024: 83 · 2023: 99 · 2022: 90 · 2021: 115 · 2020: 111 · 2019: 98 · 2018: 67 · 2017: 64 · 2016: 59 · 2015: 44 · 2014: 50 · 2013: 25 · 2012: 1
FWCI: 4.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biological Chemistry (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: National Institutes of Health (AA020518, RR016475)
National Institute on Alcohol Abuse and Alcoholism (R01AA020518, R21AA017421, R37AA020518)
National Cancer Institute (R01CA83817, R01CA083817)
National Institute of General Medical Sciences (P20GM103418)
National Center for Research Resources (P20RR021940, RR016475, P20RR016475)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitophagy, PINK1/Parkin pathway, Nix, BNIP3, mitochondrial priming, selective autophagy, neurodegenerative diseases, ischemia, energy homeostasis, cell death
MeSH terms: Aging, Animals, Disease, Humans, Mitochondria, Signal Transduction, Mitochondrial Proteins, Mitophagy

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