Cited by 79Memory and Neural MechanismsNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Fast gamma rhythms in the hippocampus promote encoding of novel object-place pairings

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Zheng, Chenguang, Bieri, Kevin Wood, Hwaun, Ernie, Colgin, Laura Lee·2016·eNeuro

Abstract

Hippocampal gamma rhythms increase during mnemonic operations (Johnson and Redish, 2007; Montgomery and Buzsáki, 2007; Sederberg et al., 2007; Jutras et al., 2009; Trimper et al., 2014) and may affect memory encoding by coordinating activity of neurons that code related information (Jensen and Lisman, 2005). Here, a hippocampal-dependent, object-place association task (Clark et al., 2000; Broadbent et al., 2004; Eacott and Norman, 2004; Lee et al., 2005; Winters et al., 2008; Barker and Warburton, 2011) was used in rats to investigate how slow and fast gamma rhythms in the hippocampus relate to encoding of memories for novel object-place associations. In novel object tasks, the degree of hippocampal dependence has been reported to vary depending on the type of novelty (Eichenbaum et al., 2007; Winters et al., 2008). Therefore, gamma activity was examined during three novelty conditions: a novel object presented in a location where a familiar object had been (NO), a familiar object presented in a location where no object had been (NL), and a novel object presented in a location where no object had been (NO+NL). The strongest and most consistent effects were observed for fast gamma rhythms during the NO+NL condition. Fast gamma power, CA3-CA1 phase synchrony, and phase-locking of place cell spikes increased during exploration of novel, compared to familiar, object-place associations. Additionally, place cell spiking during exploration of novel object-place pairings was increased when fast gamma rhythms were present. These results suggest that fast gamma rhythms promote encoding of memories for novel object-place associations.

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Authors
Zheng, C., Bieri, K. W., Hwaun, E., & Colgin, L. L.
Affiliations
The University of Texas at Austin (US)
Corresponding author
  • Zheng, Chenguang
  • Colgin, Laura Lee
Venue
eNeuro
Published
2016-03
Volume
3
Issue
2
Pages
ENEURO.0001-16.2016
ISSN
2373-2822 (ISSN-L)
OpenAlex
W2344354198
Cited by
79
References
49
Citations by year
2026: 3 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 5 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 7 · 2016: 1
FWCI
5.73
Type
journal article
Language
en
Open access
Locations
  • eNeuro (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • the Esther A. and Joseph Klingenstein Fund
  • the Alfred P. Sloan Foundation
  • National Institute of Mental Health (1F30MH100818-01A1, 1R01MH102450-01A1)
  • Office of Naval Research (N00014-14-1-0322)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
hippocampus, memory encoding, novelty, place cells, phase synchronization, phase locking, hippocampal-dependent memory, novel object recognition
MeSH terms
Place Cells, Action Potentials, Analysis of Variance, Animals, Association Learning, Discrimination, Psychological, Exploratory Behavior, Hippocampus, Locomotion, Male, Nerve Net, Spectrum Analysis, Rats, Long-Evans, Recognition, Psychology, Rats, Gamma Rhythm

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