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Dopaminergic correlates of motivated behavior: importance of drive
Open accessAbstract
In vivo brain microdialysis was used to monitor changes in dopamine (DA) release in the nucleus accumbens (NAc) during anticipatory and consummatory components of feeding behavior. During 10 daily training sessions, rats were first confined to one compartment of a testing chamber for 10 minutes. During this period (anticipatory phase) they were prevented from gaining access to a highly palatable liquid meal by a wire mesh screen. The screen was then removed and the animals were permitted to consume the meal for 20 min (consummatory phase). On removal of the screen, the latency to begin drinking decreased and the amount consumed increased as a function of days of training, both measures reaching asymptotic levels by day 7. Trained animals were implanted with dialysis probes in the NAc on day 10, and on day 12 DA release was monitored during the feeding session. Compared to controls, trained animals failed to show significantly greater increases in accumbal DA release during the anticipatory phase, all groups showing small (approximately 10%) increases on being placed in the test chamber. In contrast, compared to controls, DA release increased significantly in the NAc during consumption of the palatable meal. The magnitude of this increase was significantly enhanced (30% vs 71% peak increase) in animals that were 20 hr food deprived at the time of testing. The latter animals also showed a statistically significant increase (24%) in DA release during the anticipatory phase. A subsequent experiment in which consumption of the palatable liquid was limited to 5 ml in deprived and nondeprived animals indicated that only part of the deprivation-induced potentiation of accumbal DA release could be attributed to the larger volume consumed by the deprived animals. That is, the same volume and rate of consumption of a small amount of the liquid diet produced a significantly greater increase in accumbal DA release in deprived than in nondeprived animals (42% vs 23% peak increase). Feeding-induced increases in accumbal DA release were not due to postingestional factors as direct injections of the liquid diet into the stomach by gavage failed to produce this effect. The results of these experiments indicate (1) that consummatory rather than anticipatory aspects of feeding are robustly associated with increases in DA release in the NAc, and (2) that motivational state can influence the magnitude of the neurochemical events that are associated with goal- directed behaviors.
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“There is an increase in DA release (measured in awake, behaving animals by microdialysis or by fastscanning cyclic voltammetry) in the NAc in response to unexpected food rewards or stimuli that predict food rewards [72,308-310].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [310]
In the citing paper
“In vivo dialysis experiments show higher food-induced DA release in fasted versus satiated rats (Wilson et al., 1995).”
From Caloric deprivation increases responsivity of attention and reward brain regions to intake, anticipated intake, and images of palatable foods (2013) · cites this paper as Wilson et al., 1995
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Metadata
- Authors
- Wilson, C., Nomikos, G., Collu, M., & Fibiger, H.
- Affiliations
- University of British Columbia (CA)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1995-07-01
- Volume
- 15
- Issue
- 7
- Pages
- 5169-5178
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577888
- OpenAlex
- W1797218635
- Cited by
- 294
- References
- 40
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 4 · 2013: 5 · 2012: 10
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
- Funders
- Bristol-Myers Squibb
- Medical Research Council Canada
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- dopamine release, nucleus accumbens, feeding behavior, food drive, food deprivation, motivated behavior, goal-directed behavior, palatable food
- MeSH terms
- Animals, Behavior, Animal, Dopamine, Feeding Behavior, Food Deprivation, Male, Motivation, Nucleus Accumbens, Rats, Inbred Strains, Reaction Time, Microdialysis, Rats
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