The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Fear and the human amygdala
Open accessAbstract
We have previously reported that bilateral amygdala damage in humans compromises the recognition of fear in facial expressions while leaving intact recognition of face identity (Adolphs et al., 1994). The present study aims at examining questions motivated by this finding. We addressed the possibility that unilateral amygdala damage might be sufficient to impair recognition of emotional expressions. We also obtained further data on our subject with bilateral amygdala damage, in order to elucidate possible mechanisms that could account for the impaired recognition of expressions of fear. The results show that bilateral, but not unilateral, damage to the human amygdala impairs the processing of fearful facial expressions. This impairment appears to result from an insensitivity to the intensity of fear expressed by faces. We also confirmed a double dissociation between the recognition of facial expressions of fear, and the recognition of identity of a face: these two processes can be impaired independently, lending support to the idea that they are subserved in part by anatomically separate neural systems. Based on our data, and on what is known about the amygdala's connectivity, we propose that the amygdala is required to link visual representations of facial expressions, on the one hand, with representations that constitute the concept of fear, on the other. Preliminary data suggest the amygdala's role extends to both recognition and recall of fearful facial expressions.
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“Similarly, human amygdala lesions are related to difficulties in perceiving both fearful (Adolphs et al. 1995) and happy faces (Kipps et al. 2007).”
From The brain basis of positive and negative affect: evidence from a meta-analysis of the human neuroimaging literature (2016) · cites this paper as Adolphs et al. 1995
In the citing paper
“an idea motivated by a large literature implicating this brain structure in processing fear and threat (9), as well as in anticipation and experience of monetary loss (10).”
From Amygdala damage eliminates monetary loss aversion (2010) · cites this paper as [9]
In the citing paper
“Considerable research drawing on cross-species models delineates the amygdala, located in the medial temporal lobe, and regions of the ventral prefrontal cortex (vPFC), as key substrates underlying how the brain processes and responds to signals of danger in one's surroundings (Adolphs et al., 1995).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Adolphs et al., 1995
Citations
Cites
The expression of the emotions in man and animals.
Darwin, C. D. (1872) · J. Murray eBooks · doi:10.1037/10001-000 · Cited by 12,120
(1994) · DigitalGeorgetown (Georgetown University Library) · Cited by 10,542
DESCARTES' ERROR: Emotion, Reason, and the Human Brain
Marg, E. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03988.x · Cited by 8,178
Ekman, P. (1976) · Medical Entomology and Zoology · Cited by 4,345
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360
Self-citationThe role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Damasio, A. R. (1989) · Cognition · doi:10.1016/0010-0277(89)90005-x · Cited by 1,538
Self-citationVisual neurones responsive to faces in the monkey temporal cortex
Perrett, D. I., Rolls, E. T., & Caan, W. (1982) · Experimental Brain Research · doi:10.1007/bf00239352 · Cited by 1,385
Anterior cerebral asymmetry and the nature of emotion
Davidson, R. J. (1992) · Brain and Cognition · doi:10.1016/0278-2626(92)90065-t · Cited by 1,381
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Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study
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Klumpp, H., Fitzgerald, D. A., & Phan, K. L. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.004 · Cited by 126
Wallace, G. L., Case, L. K., Harms, M. B., Silvers, J. A., Kenworthy, L., & Martin, A. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1170-0 · Cited by 128
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Dai, L., Carter, C. S., Ying, J., Bellugi, U., Pournajafi-Nazarloo, H., & Korenberg, J. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038513 · Cited by 119
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Kennedy, D. P., & Adolphs, R. (2012) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2012.09.038 · Cited by 115
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Caouette, J. D., & Guyer, A. E. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2013.10.003 · Cited by 108
Fotros, A., Casey, K. F., Larcher, K., Verhaeghe, J. A., Cox, S. M., Gravel, P., Reader, A. J., Dagher, A., Benkelfat, C., & Leyton, M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.77 · Cited by 89
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Besteher, B., Gaser, C., & Nenadić, I. (2020) · Neuropsychobiology · doi:10.1159/000501024 · Cited by 83
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Chai, X. J., Hirshfeld-Becker, D., Biederman, J., Uchida, M., Doehrmann, O., Leonard, J. A., Salvatore, J., Kenworthy, T., Brown, A., Kagan, E., et al. (2015) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.05.004 · Cited by 70
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Thomas, S. J., Gonsalvez, C. J., & Johnstone, S. J. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.05.012 · Cited by 51
Hurlemann, R., Rehme, A. K., Diessel, M., Kukolja, J., Maier, W., Walter, H., & Cohen, M. X. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.04.004 · Cited by 51
Sánchez-Navarro, J. P., Martínez-Selva, J. M., & Román, F. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.10.023 · Cited by 48
Early functional brain development in autism and the promise of sleep fMRI
Pierce, K. (2011) · Brain Research · doi:10.1016/j.brainres.2010.09.028 · Cited by 43
Invisible expressions evoke core impressions
Laeng, B., Profeti, I., Sæther, L., Adolfsdottir, S., Lundervold, A. J., Vangberg, T., Øvervoll, M., Johnsen, S. H., & Waterloo, K. (2010) · Emotion · doi:10.1037/a0018689 · Cited by 45
YANG, T. T., MENON, V., REID, A. J., GOTLIB, I. H., & REISS, A. L. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046886.27264.ba · Cited by 40
Boucsein, K., Weniger, G., Mursch, K., Steinhoff, B. J., & Irle, E. (2001) · Neuropsychologia · doi:10.1016/s0028-3932(00)00117-2 · Cited by 36
Ziv, M., Goldin, P. R., Jazaieri, H., Hahn, K. S., & Gross, J. J. (2013) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-3-5 · Cited by 33
“The amygdala, which plays a critical role in the recognition of fear in facial expressions [6], was a natural target in studies of the neural basis of emotional reactivity in SAD.”
BackgroundPauli, W. M., Hazy, T. E., & O'Reilly, R. C. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00155 · Cited by 32
Buckwalter, J. A., Schumann, C. M., & Van Hoesen, G. W. (2008) · Experimental Brain Research · doi:10.1007/s00221-007-1203-x · Cited by 26
Offline consolidation of procedural skill learning is enhanced by negative emotional content
Javadi, A. H., Walsh, V., & Lewis, P. A. (2011) · Experimental Brain Research · doi:10.1007/s00221-010-2497-7 · Cited by 26
Changes in cortical morphology resulting from long-term amygdala damage
Boes, A. D., Mehta, S., Rudrauf, D., Van Der Plas, E., Grabowski, T., Adolphs, R., & Nopoulos, P. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr047 · Cited by 23
Self-citationZhang, X., Wang, X., Dong, D., Sun, X., Zhong, X., Xiong, G., Cheng, C., Lei, H., Chai, Y., Yu, M., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.09.003 · Cited by 11
Metadata
- Authors
- Adolphs, R., Tranel, D., Damasio, H., & Damasio, A.
- Affiliations
- University of Iowa (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1995-09-01
- Volume
- 15
- Issue
- 9
- Pages
- 5879-5891
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6577662
- OpenAlex
- W2116372303
- Cited by
- 1,138
- References
- 68
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 23 · 2021: 32 · 2020: 27 · 2019: 32 · 2018: 24 · 2017: 34 · 2016: 33 · 2015: 35 · 2014: 49 · 2013: 45 · 2012: 65
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- Life Sciences Research Foundation
- National Institute of Neurological Disorders and Stroke (NS-19632)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, fear recognition, facial expressions, face identification, double dissociation, amygdala connectivity, concept of fear
- MeSH terms
- Amygdala, Art, Brain Damage, Chronic, Brain Diseases, Emotions, Face, Facial Expression, Fear, Humans, Magnetic Resonance Imaging, Neuropsychological Tests, Pattern Recognition, Visual, Social Behavior
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