Segregating intra-amygdalar responses to dynamic facial emotion with cytoarchitectonic maximum probability maps
Abstract
Multiple lines of evidence converge on the human amygdala as a core moderator of facial emotion perception. The major subregions of the human amygdala have been anatomically delineated, but the individual contribution of these subregions to facial emotion perception is unclear. Here we combined functional MRI (fMRI) with cytoarchitectonically defined maximum probabilistic maps to investigate the response characteristics of amygdala subregions in 14 subjects presented with dynamic animations of angry and happy relative to neutral facial expressions. We localized facial emotion-related signal changes in the basolateral and superficial (cortical) subregions of the left amygdala, with most robust responses observed to happy faces. Moreover, we demonstrate a differential neural response to happy faces in ventromedial prefrontal cortex, which is consistent with a hypothesized role of this brain region in positive valence processing. Furthermore, angry and happy faces both evoked temporopolar responses. Our findings extend current models of facial emotion perception in humans by suggesting an intrinsic functional differentiation within the amygdala related to the extraction of value from facial expressions.
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Males with positive resting-state functional connectivity between parieto-occipital regions and the basolateral amygdala may have memory problems, because the basolateral amygdala is important for memory in addition to emotional processing.
“Although all sub-regions are relevant for emotional processing (Ball et al., 2007, Hurlemann et al., 2008, Bzdok et al., 2013a), BLA is additionally important for memory function (Bzdok et al., 2013a); therefore, males demonstrating positive RSFC between parieto-occipital and BLA may report problems with memory functions.”
From Developmental sex differences in resting state functional connectivity of amygdala sub-regions (2015) · cites this paper as Hurlemann et al., 2008
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- Authors
- Hurlemann, R., Rehme, A. K., Diessel, M., Kukolja, J., Maier, W., Walter, H., & Cohen, M. X.
- Affiliations
- University of Bonn (DE)
- Corresponding author
- Hurlemann, René
- Venue
- Journal of Neuroscience Methods
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 172
- Issue
- 1
- Pages
- 13-20
- ISSN
- 0165-0270 (ISSN-L)
- OpenAlex
- W2110906773
- Cited by
- 51
- References
- 76
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Neuroscience Methods (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (01GW0671)
- Deutsche Forschungsgemeinschaft (HU1302/2-1)
- Volkswagen Foundation (80 777)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- amygdala, emotional face processing, dynamic facial expressions, amygdala subregions, basolateral amygdala, superficial amygdala, ventromedial prefrontal cortex, angry faces, happy faces
- MeSH terms
- Adult, Amygdala, Brain Mapping, Emotions, Facial Expression, Female, Humans, Image Processing, Computer-Assisted, Male, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Probability, Reaction Time
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