Cited by 205Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsCell Adhesion Molecules Research

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Time-Dependent Reversal of Long-Term Potentiation by an Integrin Antagonist

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Stäubli, Ursula, Chun, Daniel, Lynch, Gary·1998·The Journal of Neuroscience

DOI 10.1523/jneurosci.18-09-03460.1998PMC PMC6792671

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Abstract

The integrin antagonist Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) was applied by local ejection to one of two recording sites in hippocampal slices at various times before and after long-term potentiation (LTP) was induced at both sites with theta burst stimulation. Applications 10 min before, immediately after, and 10 min after induction caused LTP at the experimental site to decay steadily relative to that at the within-slice control site. However, application at 25 min or more after induction had no detectable effect on potentiation. Similar results were obtained when the integrin antagonist was perfused into the slice rather than applied locally. The time period after induction during which GRGDSP interfered with LTP consolidation corresponds to that during which LTP is susceptible to reversal by low-frequency afferent stimulation and newly formed memories are vulnerable to various disruptive treatments. Comparable experiments using a peptide that blocks an extracellular binding site of neural cell adhesion molecules (NCAMs) did not yield time-dependent reversal of LTP; i.e., an antagonist that interacts with the fourth immunoglobulin-like domain reduced LTP when applied before induction but not afterward. Moreover, LTP formation occurred normally in the presence of an antibody against the fibronectin repeat domain of NCAM. These results suggest that integrin activation and signaling occurring over several minutes after LTP induction are necessary for stabilizing synaptic potentiation and by inference may be required for the conversion of new memories into a not readily disrupted state.

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Calcium's Role in Mechanotransduction during Muscle Development
Damm, T. B., & Egli, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000356667 · Cited by 14,552
Integrins: Versatility, modulation, and signaling in cell adhesion
Hynes, R. O. (1992) · Cell · doi:10.1016/0092-8674(92)90115-s · Cited by 9,857
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
Pierschbacher, M. D., & Ruoslahti, E. I. (1984) · Nature · doi:10.1038/309030a0 · Cited by 3,690
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Burridge, K., Fath, K. R., Kelly, T. J., Nuckolls, G. H., & Turner, C. E. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002415 · Cited by 2,120
Memory consolidation, retrograde amnesia and the hippocampal complex
Nadel, L., & Moscovitch, M. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80010-4 · Cited by 1,924
Interaction of plasma membrane fibronectin receptor with talin—a transmembrane linkage
Horwitz, A. F., Duggan, K., Buck, C. A., Beckerle, M. C., & Burridge, K. (1986) · Nature · doi:10.1038/320531a0 · Cited by 1,191
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF
Isackson, P. J., Huntsman, M. M., Murray, K. D., & Gall, C. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90234-q · Cited by 711 · cited 2×
“, 1997), the link to MAP kinases could account for the gene induction reported to occur with high-frequency synaptic activity (Isackson et al., 1991; Andreasson and Worley, 1995; Link et al., 1995) and potentially could add a genomic contribution to the later stages of LTP consolidation.”
Background
Somatodendritic expression of an immediate early gene is regulated by synaptic activity.
Link, W., Konietzko, U., Kauselmann, G., Krug, M., Schwanke, B., Frey, U., & Kuhl, D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5734 · Cited by 710
Integrin-mediated cell adhesion activates mitogen-activated protein kinases.
Chen, Q., Kinch, M. S., Lin, T., Burridge, K., & Juliano, R. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47058-5 · Cited by 660
PSA-NCAM is required for activity-induced synaptic plasticity.
Muller, D., Wang, C., Skibo, G. G., Toni, N., Cremer, H., Calaora, V., Rougon, G., & Kiss, J. Z. (1996) · Neuron · doi:10.1016/s0896-6273(00)80174-9 · Cited by 625

Show all 57 references

Research works printed but not linked: 1

Russell RW (1959) Brain, memory, learning. (Clarendon, Oxford).

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Authors: Stäubli, U., Chun, D., & Lynch, G.
Affiliations: University of California, Irvine (US)
ORCID: Lynch, Gary
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1998-05-01
Volume: 18
Issue: 9
Pages: 3460-3469
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.18-09-03460.1998
PMC: PMC6792671
OpenAlex: W1555498151
Cited by: 205
References: 57
Citations by year: 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 8 · 2013: 6 · 2012: 6
FWCI: 6.86
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Whitehall Foundation
Air Force Office of Scientific Research (F49620)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords: long-term potentiation, integrin antagonism, GRGDSP peptide, hippocampus, theta burst stimulation, CD56, synaptic potentiation, memory consolidation, integrin signaling
MeSH terms: Amino Acid Sequence, Animals, Binding, Competitive, Electric Stimulation, Molecular Sequence Data, Oligopeptides, Time Factors, Integrins, Rats, Sprague-Dawley, Long-Term Potentiation, Neural Cell Adhesion Molecules, Excitatory Postsynaptic Potentials, Rats, In Vitro Techniques

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Time-Dependent Reversal of Long-Term Potentiation by an Integrin Antagonist

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