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Distinct Roles of the β1-Class Integrins at the Developing and the Mature Hippocampal Excitatory Synapse

Huang, Zhen, Shimazu, Kazuhiro, Woo, Newton H., Zang, Keling, Müller, Ulrich, Lu, Bai, Reichardt, Louis F.·2006·The Journal of Neuroscience
DOI 10.1523/jneurosci.3526-06.2006
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Abstract

Integrins are a large family of cell adhesion receptors involved in a variety of cellular functions. To study their roles at central synapses, we used two cre recombinase lines to delete the Itgb1 β1 integrin gene in forebrain excitatory neurons at different developmental stages. Removal of the β1 integrins at an embryonic stage resulted in severe cortical lamination defects without affecting the cellular organization of pyramidal neurons in the CA3 and CA1 regions of the hippocampus. Whereas the hippocampal neurons underwent normal dendritic and synaptic differentiation, the adult synapses exhibited deficits in responses to high-frequency stimulation (HFS), as well as in long-term potentiation (LTP). Deletion of β1 integrin at a later postnatal stage also impaired LTP but not synaptic responses to HFS. Thus, the β1-class integrins appear to play distinct roles at different stages of synaptic development, critical for the proper maturation of readily releasable pool of vesicles during early development but essential for LTP throughout adult life.

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  1. 10.1016/S0896-6273(00)81089-2 · DOI
  2. Bahr, 1997, Arg-Gly-Asp-Ser-selective adhesion and the stabilization of long-term potentiation: pharmacological studies and the characterization of a candidate matrix receptor, J Neurosci, 17, 1320, 10.1523/JNEUROSCI.17-04-01320.1997 · DOI · Paper page
  3. 10.1016/S0896-6273(03)00718-9 · DOI
  4. 10.1016/S0896-6273(00)80347-5 · DOI
  5. 10.1111/j.1471-4159.2005.03062.x · DOI
  6. Beumer, 2002, Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development, Development, 129, 3381, 10.1242/dev.129.14.3381 · DOI
  7. Beumer, 1999, A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila, Development, 126, 5833, 10.1242/dev.126.24.5833 · DOI
  8. 10.1126/science.1072356 · DOI
  9. 10.1523/JNEUROSCI.5241-03.2004 · DOI
  10. Chan, 2003, Integrin requirement for hippocampal synaptic plasticity and spatial memory, J Neurosci, 23, 7107, 10.1523/JNEUROSCI.23-18-07107.2003 · DOI
  11. 10.1038/35077101 · DOI
  12. 10.1126/science.7667637 · DOI
  13. 10.1126/science.1107470 · DOI
  14. 10.1016/S0306-4522(01)00173-7 · DOI · Paper page
  15. 10.1016/0896-6273(95)90038-1 · DOI
  16. 10.1038/nature01147 · DOI · Paper page
  17. 10.1038/nature02896 · DOI
  18. 10.1016/S0896-6273(00)80338-4 · DOI · Paper page
  19. 10.1016/S0896-6273(00)00007-6 · DOI · Paper page
  20. 10.1016/S0896-6273(00)80175-0 · DOI
  21. 10.1073/pnas.202035899 · DOI · Paper page
  22. 10.1016/0896-6273(92)90070-T · DOI
  23. 10.1038/369493a0 · DOI
  24. 10.1038/42954 · DOI
  25. Gorski, 2002, Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage, J Neurosci, 22, 6309, 10.1523/JNEUROSCI.22-15-06309.2002 · DOI
  26. 10.1016/j.cell.2004.11.035 · DOI
  27. 10.1016/S0896-6273(01)00374-9 · DOI
  28. 10.1038/35079 · DOI
  29. 10.1016/S0896-6273(04)00007-8 · DOI
  30. 10.1038/366569a0 · DOI
  31. Hoang, 1998, Genetic analysis on the role of integrin during axon guidance in Drosophila, J Neurosci, 18, 7847, 10.1523/JNEUROSCI.18-19-07847.1998 · DOI
  32. Huang, 1998, Expression of integrin-associated protein gene associated with memory formation in rats, J Neurosci, 18, 4305, 10.1523/JNEUROSCI.18-11-04305.1998 · DOI
  33. 10.1016/S0092-8674(02)00971-6 · DOI
  34. 10.1111/j.1469-7793.2001.0243l.x · DOI
  35. 10.1126/science.290.5492.750 · DOI · Paper page
  36. 10.1016/S0306-4522(01)00540-1 · DOI
  37. 10.1074/jbc.M210225200 · DOI
  38. 10.1073/pnas.0601354103 · DOI · Paper page
  39. 10.1073/pnas.0307813100 · DOI
  40. 10.1152/jn.00783.2002 · DOI
  41. 10.1016/j.mcn.2006.04.005 · DOI
  42. Martin, 1997, Integrins mediate adhesion to agrin and modulate agrin signaling, Development, 124, 3909, 10.1242/dev.124.19.3909 · DOI
  43. 10.1523/JNEUROSCI.1432-05.2005 · DOI
  44. 10.1083/jcb.200406020 · DOI
  45. Mozhayeva, 2002, Development of vesicle pools during maturation of hippocampal synapses, J Neurosci, 22, 654, 10.1523/JNEUROSCI.22-03-00654.2002 · DOI
  46. 10.1038/9149 · DOI
  47. 10.1523/JNEUROSCI.4359-05.2006 · DOI · Paper page
  48. 10.1038/nature01790 · DOI
  49. 10.1016/S0169-328X(98)00007-2 · DOI
  50. Pinkstaff, 1999, Integrin subunit gene expression is regionally differentiated in adult brain, J Neurosci, 19, 1541, 10.1523/JNEUROSCI.19-05-01541.1999 · DOI · Paper page
  51. Pozzo-Miller, 1999, Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knock-out mice, J Neurosci, 19, 4972, 10.1523/JNEUROSCI.19-12-04972.1999 · DOI
  52. 10.1016/S0896-6273(00)00098-2 · DOI
  53. 10.1146/annurev.ne.14.030191.002531 · DOI · Paper page
  54. 10.1016/S0896-6273(00)00065-9 · DOI
  55. Rohrbough, 2000, Integrin-mediated regulation of synaptic morphology, transmission, and plasticity, J Neurosci, 20, 6868, 10.1523/JNEUROSCI.20-18-06868.2000 · DOI
  56. 10.1016/S0896-6273(00)80146-4 · DOI
  57. 10.1126/science.7901909 · DOI
  58. 10.1016/S0896-6273(04)00222-3 · DOI · Paper page
  59. 10.1016/S0092-8674(00)80877-6 · DOI · Paper page
  60. Schikorski, 1997, Quantitative ultrastructural analysis of hippocampal excitatory synapses, J Neurosci, 17, 5858, 10.1523/JNEUROSCI.17-15-05858.1997 · DOI · Paper page
  61. 10.1038/86042 · DOI · Paper page
  62. 10.1242/dev.01532 · DOI
  63. 10.1016/S0896-6273(00)80789-8 · DOI
  64. 10.1523/JNEUROSCI.1345-04.2004 · DOI
  65. 10.1016/S0092-8674(03)00113-2 · DOI
  66. Sonner, 2005, Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fear, Mol Pharmacol, 68, 61, 10.1124/mol.104.009936 · DOI
  67. 10.1038/5007 · DOI
  68. 10.1101/gad.9.15.1883 · DOI
  69. 10.1016/S0896-6273(00)00109-4 · DOI
  70. 10.1016/S0896-6273(02)01137-6 · DOI
  71. 10.1016/S0896-6273(02)00748-1 · DOI
  72. Tomaselli, 1993, Expression of β1 integrins in sensory neurons of the dorsal root ganglion and their functions in neurite outgrowth on two laminin isoforms, J Neurosci, 13, 4880, 10.1523/JNEUROSCI.13-11-04880.1993 · DOI
  73. 10.1016/S0092-8674(00)81826-7 · DOI · Paper page
  74. 10.1083/jcb.135.3.767 · DOI · Paper page
  75. 10.1016/0896-6273(95)90268-6 · DOI
  76. Weaver, 1995, Expression and in vitro function of β1-integrin laminin receptors in the developing avian ciliary ganglion, J Neurosci, 15, 5275, 10.1523/JNEUROSCI.15-07-05275.1995 · DOI
  77. 10.1016/S0896-6273(01)80039-8 · DOI
  78. 10.1016/S0896-6273(00)81153-8 · DOI
  79. 10.1016/S0092-8674(02)00910-8 · DOI

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Metadata

Authors
Huang, Z., Shimazu, K., Woo, N. H., Zang, K., Müller, U., Lu, B., & Reichardt, L. F.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2006-10-25
Volume
26
Issue
43
Pages
11208-11219
ISSN
  • 0270-6474
  • 1529-2401
DOI
10.1523/jneurosci.3526-06.2006
Cited by
142
References
4
Language
en
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)

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