Cited by 401Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

Physiologically Distinct Temporal Cohorts of Cortical Interneurons Arise from Telencephalic Olig2 -Expressing Precursors

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Abstract

Inhibitory GABAergic interneurons of the mouse neocortex are a highly heterogeneous population of neurons that originate from the ventral telencephalon and migrate tangentially up into the developing cortical plate. The majority of cortical interneurons arise from a transient embryonic structure known as the medial ganglionic eminence (MGE), but how the remarkable diversity is specified in this region is not known. We have taken a genetic fate mapping strategy to elucidate the temporal origins of cortical interneuron subtypes within the MGE. We used an inducible form of Cre under the regulation of Olig2, a basic helix-loop-helix transcription factor highly expressed in neural progenitors of the MGE. We observe that the physiological subtypes of cortical interneurons are, to a large degree, unique to their time point of generation.

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Crossref · 10.1523/jneurosci.1807-07.2007

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Metadata

Authors
Miyoshi, G., Butt, S. J. B., Takebayashi, H., & Fishell, G.
Affiliations
  • New York University (US)
  • National Institute for Physiological Sciences (JP)
Venue
The Journal of Neuroscience
Published
2007-07-18
Volume
27
Issue
29
Pages
7786-7798
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2004544578
Cited by
400
References
69
Citations by year
2026: 8 · 2025: 18 · 2024: 13 · 2023: 11 · 2022: 20 · 2021: 22 · 2020: 23 · 2019: 28 · 2018: 21 · 2017: 19 · 2016: 20 · 2015: 14 · 2014: 23 · 2013: 36 · 2012: 21
FWCI
7.59
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • Japan Society for the Promotion of Science
  • National Institute of Mental Health (R01MH068469)
  • National Institute of Neurological Disorders and Stroke (R01NS039007)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cortical interneurons, medial ganglionic eminence, Olig2, GABAergic interneurons, interneuron subtypes, neural progenitor cells, fate mapping, neocortex development, ventral telencephalon
MeSH terms
Oligodendrocyte Transcription Factor 2, Action Potentials, Age Factors, Animals, Animals, Newborn, Cell Differentiation, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Interneurons, Mice, Transgenic, Nerve Tissue Proteins, Stem Cells, Telencephalon, Patch-Clamp Techniques, Gene Expression Regulation, Developmental, Body Patterning, Green Fluorescent Proteins, Mice, Basic Helix-Loop-Helix Proteins, Basic Helix-Loop-Helix Transcription Factors, In Vitro Techniques

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