Cited by 57Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

Conserved rules in embryonic development of cortical interneurons

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Laclef, Christine, Métin, Christine·2018·Seminars in Cell & Developmental Biology

Abstract

This review will focus on early aspects of cortical interneurons (cIN) development from specification to migration and final positioning in the human cerebral cortex. These mechanisms have been largely studied in the mouse model, which provides unique possibilities of genetic analysis, essential to dissect the molecular and cellular events involved in cortical development. An important goal here is to discuss the conservation and the potential divergence of these mechanisms, with a particular interest for the situation in the human embryo. We will thus cover recent works, but also revisit older studies in the light of recent data to better understand the developmental mechanisms underlying cIN differentiation in human. Because cIN are implicated in severe developmental disorders, understanding the molecular and cellular mechanisms controlling their differentiation might clarify some causes and potential therapeutic approaches to these important clinical conditions.

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Crossref · 10.1016/j.semcdb.2017.09.017

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  • Distinct basal ganglia existed in the last common ancestor of vertebrates over 500 million years ago.

    “distinct basal ganglia were already present in the last common ancestor of vertebrates more than 500 million years ago3”

    From Innovations present in the primate interneuron repertoire (2020) · cites this paper as [3]

  • The basal ganglia nuclei are thought to be deeply conserved, with lamprey retaining homologous nuclei, circuitry and basic cell types to mice.

    “the subcortical nuclei comprising the basal ganglia are thought to be deeply conserved–so much so that the lamprey, which shares a last common ancestor with mammals more than 500 million years ago, retains nuclei, circuitry and basic cell types that are homologous to those in mice3.”

    From Innovations present in the primate interneuron repertoire (2020) · cites this paper as [3]

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Authors
Laclef, C., & Métin, C.
Affiliations
Inserm (FR)
Corresponding author
Métin, Christine
Venue
Seminars in Cell & Developmental Biology
Publisher
Elsevier BV
Published
2018-04
Volume
76
Pages
86-100
ISSN
1084-9521 (ISSN-L)
OpenAlex
W2755139995
Cited by
57
References
171
Citations by year
2026: 3 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 6 · 2019: 6 · 2018: 9
FWCI
0.87
Type
journal article
Language
en
Locations
  • Seminars in Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
Funders
Agence Nationale de la Recherche (ANR-14-CE13-0018)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords
cortical interneurons, embryonic development, interneuron specification, neuronal migration, human cerebral cortex, developmental disorders, interneuron differentiation
MeSH terms
Cell Differentiation, Cerebral Cortex, Humans, Interneurons

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