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Cited by 148Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Dendritic Spine Heterogeneity Determines Afferent-Specific Hebbian Plasticity in the Amygdala

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Humeau, Yann, Herry, Cyril, Kemp, Nicola, Shaban, Hamdy, Fourcaudot, Elodie, Bissière, Stephanie, Lüthi, Andreas·2005·Neuron
DOI 10.1016/j.neuron.2004.12.019
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Abstract

Functional compartmentalization of dendrites is thought to underlie afferent-specific integration of neural activity in laminar brain structures. Here we show that in the lateral nucleus of the amygdala (LA), an area lacking apparent laminar organization, thalamic and cortical afferents converge on the same dendrites, contacting neighboring but morphologically and functionally distinct spine types. Large spines contacted by thalamic afferents exhibited larger Ca(2+) transients during action potential backpropagation than did small spines contacted by cortical afferents. Accordingly, induction of Hebbian plasticity, dependent on postsynaptic spikes, was restricted to thalamic afferents. This synapse-specific effect involved activation of R-type voltage-dependent Ca(2+) channels preferentially located at thalamic inputs. These results indicate that afferent-specific mechanisms of postsynaptic, associative Hebbian plasticity in LA projection neurons depend on local, spine-specific morphological and molecular properties, rather than global differences between dendritic compartments.

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  • Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning.

    “Several lines of indirect evidence support the idea that this plasticity occurs as a result of a Hebbian mechanism through which depolarization of LA pyramidal neurons by the shock US coincident with weaker activation of the same cells by auditory CS inputs results in fear learning (8–18).”

    From Optical activation of lateral amygdala pyramidal cells instructs associative fear learning (2010) · cites this paper as [17]

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Authors
Humeau, Y., Herry, C., Kemp, N., Shaban, H., Fourcaudot, E., Bissière, S., & Lüthi, A.
Affiliations
  • Centre National de la Recherche Scientifique (FR)
  • Friedrich Miescher Institute (CH)
  • University of Basel (CH)
Corresponding author
Lüthi, Andreas
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2005-01
Volume
45
Issue
1
Pages
119-131
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2004.12.019
OpenAlex
W2123483502
Cited by
148
References
62
Citations by year
2026: 3 · 2025: 1 · 2024: 6 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 2 · 2015: 6 · 2014: 12 · 2013: 14 · 2012: 11
FWCI
4.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
lateral amygdala, Hebbian plasticity, thalamic afferents, cortical afferents, dendritic compartmentalization, calcium transients, action potential backpropagation, R-type calcium channels
MeSH terms
Action Potentials, Afferent Pathways, Amygdala, Animals, Calcium Channel Blockers, Cerebral Cortex, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Synaptic Transmission, Neuronal Plasticity, Organ Culture Techniques, Phytohemagglutinins, Synaptic Membranes, Thalamus, Calcium Channels, Presynaptic Terminals, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Calcium Signaling, Dendritic Spines, Mice

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