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Experience-Dependent Coincident Expression of the Effector Immediate-Early Genes Arc and Homer 1a in Hippocampal and Neocortical Neuronal Networks
Open accessAbstract
The transcription of the immediate-early genes Arc and Homer 1a (H1a) is dynamically regulated in response to synaptic activity; their protein products function at the postsynaptic sites of excitatory synapses. Previous studies demonstrate a role for Arc in the maintenance of long-term potentiation and in memory consolidation processes and indicate a role for H1a in modifying glutamatergic signaling pathways. Using double-label fluorescence in situ hybridization, we demonstrate that Arc and H1a RNA expression is induced strongly in the same neurons of rat hippocampus and neocortex after exploration of a novel environment. These findings support the view that novel experience activates a cell-specific genomic program and that Arc and H1a may function in concert in the structural and functional modifications of dendrites that lead to long-term changes in synaptic efficacy.
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Cites
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Metadata
- Authors
- Vazdarjanova, A., McNaughton, B. L., Barnes, C. A., Worley, P. F., & Guzowski, J. F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-12-01
- Volume
- 22
- Issue
- 23
- Pages
- 10067-10071
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1937327101
- Cited by
- 307
- References
- 4
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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