Spatial and stimulus-type tuning in the LEC, MEC, POR, PrC, CA1, and CA3 during spontaneous item recognition memory: Spatial and Stimulus-Type Tunings in Recognition Memory
Abstract
According to the "two streams" hypothesis, the lateral entorhinal (LEC) and the perirhinal (PrC) cortices process information related to items (a "what" stream), the postrhinal (POR) and the medial entorhinal cortices (MEC) process spatial information (a "where" stream), and both types of information are integrated in the hippocampus (HIP). However, within the framework of memory function, only the HIP is reliably shown to preferentially process spatial information, and the PrC items' features. In contrast, the role of the LEC and MEC in memory is virtually unexplored, and conflicting results emerge for the POR. Moreover, the specific contribution of the hippocampal subfields CA1 and CA3 to spatial and non-spatial memory is not thoroughly understood. To investigate which of these areas is specifically tuned to spatial demands or stimulus identity (odor or object), we assessed the pattern of activation of these areas during recognition memory by detecting the immediate-early gene Arc, commonly used as a marker of neuronal activation. We report that all MTL areas were recruited during the spatial and the non-spatial tasks. However, the LEC, MEC, POR, and CA1 were activated to a comparable level in spatial and non-spatial tasks, while the PrC was tuned to stimulus-type, not spatial demands, and CA3 to spatial demands but not stimulus-type. Results are discussed within the frame of a recent model suggesting that the MTL could be segregated in terms of memory processes, such as recollection and familiarity, rather than information content.
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The LEC preferentially processes object-associated information, e.g., the past and current locations of objects, and the context of the objects.
“Behavioral, imaging and electrophysiological recording data suggest that LEC preferentially processes object-associated information, e.g., the past and current locations of objects (Beer et al., 2013; Deshmukh and Knierim, 2011; Tsao et al., 2013; Van Cauter et al., 2013), and the context of the objects (Wilson et al., 2013b; Wilson et al., 2013c).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Beer et al., 2013
Both CA1 and CA3 areas (more CA1 than CA3) were recruited in the NOP test.
“Both CA1 and CA3 areas (more CA1 than CA3) were recruited in the NOP test (Beer et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Beer et al., 2013
Higher c-fos expression induced by the OPP, but not NOP, test was found in the hippocampal CA1 and CA3 subregions, while Arc mRNA imaging data showed higher involvement of CA3 in OPP than NOP.
“Higher c-fos expression induced by the OPP, but not NOP, test was found in the hippocampal CA1 and CA3 subregions (Mendez et al., 2015), while Arc mRNA imaging data showed higher involvement of CA3 in OPP than NOP (Beer et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Beer et al., 2013
CA1 area was required in both object and location conditions, while CA3 was more recruited for OPP than NOP.
“CA1 area was required in both object and location conditions, while CA3 was more recruited for OPP than NOP (Beer et al., 2013).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Beer et al., 2013
Imaging data show the CA1 to be activated during both spatial and nonspatial processing, while CA3 activation codes primarily information about place.
“Imaging data also show the CA1 to be activated during both spatial and nonspatial processing, while CA3 activation codes primarily information about place (Beer et al., 2013; Beer et al., 2014).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Beer et al., 2013
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Self-citationRecognition memory-induced gene expression in the perirhinal cortex: A transcriptomic analysis
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Remembering the gist of an event over a lifetime depends on the hippocampusPreprint
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Evidence for grid-cell-like activity in the time domain
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Perirhinal Cortex: Neural Representations ☆
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Targeting diaschisis to alleviate memory deficits after experimental stroke
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Aberrant increased GABAergic neuronal activity in postrhinal cortex impairs spatial memory
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- Authors
- Beer, Z., Chwiesko, C., Kitsukawa, T., & Sauvage, M. M.
- Affiliations
- Ruhr University Bochum (DE)
- The University of Osaka (JP)
- Corresponding author
- Sauvage, Magdalena M.
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2013-09-18
- Volume
- 23
- Issue
- 12
- Pages
- 1425-1438
- ISSN
- 1050-9631 (ISSN-L)
- OpenAlex
- W1606464716
- Cited by
- 49
- References
- 84
- Citations by year
- 2026: 4 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Economía y Competitividad
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- recognition memory, spatial memory, lateral entorhinal cortex, medial entorhinal cortex, perirhinal cortex, postrhinal cortex, hippocampal CA1, hippocampal CA3, medial temporal lobe
- MeSH terms
- Analysis of Variance, Animals, Cytoskeletal Proteins, Gene Expression Regulation, Male, Mice, Inbred C57BL, Nerve Tissue Proteins, Neural Pathways, Space Perception, Signal Transduction, Entorhinal Cortex, Recognition, Psychology, Mice
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