Relevance of synaptic tagging and capture to the persistence of long-term potentiation and everyday spatial memory
Open accessAbstract
Memory for inconsequential events fades, unless these happen before or after other novel or surprising events. However, our understanding of the neurobiological mechanisms of novelty-enhanced memory persistence is mainly restricted to aversive or fear-associated memories. We now outline an "everyday appetitive" behavioral model to examine whether and how unrelated novelty facilitates the persistence of spatial memory coupled to parallel electrophysiological studies of the persistence of long-term potentiation (LTP). Across successive days, rats were given one trial per day to find food in different places and later had to recall that day's location. This task is both hippocampus and NMDA receptor dependent. First, encoding with low reward induced place memory that decayed over 24 h; in parallel, weak tetanization of CA1 synapses in brain slices induced early-LTP fading to baseline. Second, novelty exploration scheduled 30 min after this weak encoding resulted in persistent place memory; similarly, strong tetanization--analogous to novelty--both induced late-LTP and rescued early- into late-LTP on an independent but convergent pathway. Third, hippocampal dopamine D1/D5 receptor blockade or protein synthesis inhibition within 15 min of exploration prevented persistent place memory and blocked late-LTP. Fourth, symmetrically, when spatial memory was encoded using strong reward, this memory persisted for 24 h unless encoding occurred under hippocampal D1/D5 receptor blockade. Novelty exploration before this encoding rescued the drug-induced memory impairment. Parallel effects were observed in LTP. These findings can be explained by the synaptic tagging and capture hypothesis.
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Exploration of a novel environment can make a memory for a weak event more persistent.
“exploration of a novel environment can make a memory for a ‘weak’ event more persistent [70–72].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [72]
24hr memory is enhanced in rats for rewarded locations even after only a single exposure.
“24hr memory is enhanced in rats for rewarded locations (even after only a single exposure)”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [72]
Intrahippocampal application of the D1/D5 receptor antagonist SCH23390 during novelty exploration diminishes memory retention.
“intrahippocampal application of the D1/D5 receptor antagonist SCH23390 during novelty exploration diminishes memory retention [72].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [72]
This long-term memory for rewarded locations can be blocked by a D1/D5 receptor antagonist at the time of encoding.
“this long-term memory can be blocked by a D1/D5 receptor antagonist at the time of encoding [72].”
From A neoHebbian framework for episodic memory; role of dopamine-dependent late LTP (2011) · cites this paper as [72]
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- Authors
- Wang, S.-H., Redondo, R. L., & Morris, R. G. M.
- Affiliations
- University of Edinburgh (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2010-10-20
- Volume
- 107
- Issue
- 45
- Pages
- 19537-19542
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2984182
- OpenAlex
- W2070250157
- Cited by
- 251
- References
- 45
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 29 · 2023: 19 · 2022: 18 · 2021: 18 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 19 · 2016: 18 · 2015: 18 · 2014: 17 · 2013: 11 · 2012: 9
- FWCI
- 5.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- synaptic tagging and capture, long-term potentiation, spatial memory, hippocampus, NMDA receptor, dopamine D1/D5 receptors, protein synthesis, place learning, CA1 synapses, memory consolidation
- MeSH terms
- Animals, Behavior, Animal, Hippocampus, Memory, Synapses, Time Factors, Receptors, N-Methyl-D-Aspartate, Receptors, Dopamine D1, Long-Term Potentiation, Receptors, Dopamine D5, Rats, CA1 Region, Hippocampal
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