The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3
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A well-accepted model of episodic memory involves the processing of spatial and non-spatial information by segregated pathways and their association within the hippocampus. However, these pathways project to distinct proximodistal levels of the hippocampus. Moreover, spatial and non-spatial subnetworks segregated along this axis have been recently described using memory tasks with either a spatial or a non-spatial salient dimension. Here, we tested whether the concept of segregated subnetworks and the traditional model are reconcilable by studying whether activity within CA1 and CA3 remains segregated when both dimensions are salient, as is the case for episodes. Simultaneously, we investigated whether temporal or spatial information bound to objects recruits similar subnetworks as items or locations per se, respectively. To do so, we studied the correlations between brain activity and spatial and/or temporal discrimination ratios in proximal and distal CA1 and CA3 by detecting Arc RNA in mice. We report a robust proximodistal segregation in CA1 for temporal information processing and in both CA1 and CA3 for spatial information processing. Our results suggest that the traditional model of episodic memory and the concept of segregated networks are reconcilable, to a large extent and put forward distal CA1 as a possible "home" location for time cells.
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The distal part of the CA1 region appears to be mainly involved in non-spatial memory, while the proximal part is supposed to play a more important role in tasks depending on spatial information.
“While the distal part of the CA1 region appears to be mainly involved in non-spatial memory, the proximal part is supposed to play a more important role in tasks depending on spatial information [39,40].”
From Characterization of a Mouse Model of Alzheimer’s Disease Expressing Aβ4-42 and Human Mutant Tau (2021) · cites this paper as [40]
The where component activated both CA1 and CA3 areas after the ELM2-1 test.
“the where component activated both CA1 and CA3 areas after the ELM2–1 test”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Beer et al., 2018
Higher Arc RNA expression was found in the distal CA1 area for processing of the when component.
“higher Arc RNA expression was found in the distal CA1 area for the processing of the when component”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Beer et al., 2018
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- Authors
- Beer, Z., Vavra, P., Atucha, E., Rentzing, K., Heinze, H.-J., & Sauvage, M. M.
- Affiliations
- Ruhr University Bochum (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Leibniz Institute for Neurobiology (DE)
- Center for Behavioral Brain Sciences (DE)
- Corresponding author
- Sauvage, Magdalena M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2018-08-28
- Volume
- 16
- Issue
- 8
- Pages
- e2006100
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC6136809
- OpenAlex
- W2889000691
- Cited by
- 44
- References
- 79
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 5 · 2021: 7 · 2020: 7 · 2019: 5
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Update notices
- new_version (2018-09-13)
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
- Dokumentenrepositorium der RUB (Ruhr University Bochum) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, CA1, CA3, episodic memory, spatial memory, temporal memory, time cells, mice
- MeSH terms
- Animals, Hippocampus, Male, Memory, Mice, Inbred C57BL, Temporal Lobe, Mice, CA1 Region, Hippocampal, CA3 Region, Hippocampal, Spatial Processing
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