Cited by 83Attention Deficit Hyperactivity DisorderFunctional Brain Connectivity StudiesNeural and Behavioral Psychology Studies

Modality-spanning deficits in attention-deficit/hyperactivity disorder in functional networks, gray matter, and white matter

Open access
Kessler, Daniel, Angstadt, Michael, Welsh, Robert C., Sripada, Chandra·2014·The Journal of Neuroscience

Abstract

Previous neuroimaging investigations in attention-deficit/hyperactivity disorder (ADHD) have separately identified distributed structural and functional deficits, but interconnections between these deficits have not been explored. To unite these modalities in a common model, we used joint independent component analysis, a multivariate, multimodal method that identifies cohesive components that span modalities. Based on recent network models of ADHD, we hypothesized that altered relationships between large-scale networks, in particular, default mode network (DMN) and task-positive networks (TPNs), would co-occur with structural abnormalities in cognitive regulation regions. For 756 human participants in the ADHD-200 sample, we produced gray and white matter volume maps with voxel-based morphometry, as well as whole-brain functional connectomes. Joint independent component analysis was performed, and the resulting transmodal components were tested for differential expression in ADHD versus healthy controls. Four components showed greater expression in ADHD. Consistent with our a priori hypothesis, we observed reduced DMN-TPN segregation co-occurring with structural abnormalities in dorsolateral prefrontal cortex and anterior cingulate cortex, two important cognitive control regions. We also observed altered intranetwork connectivity in DMN, dorsal attention network, and visual network, with co-occurring distributed structural deficits. There was strong evidence of spatial correspondence across modalities: For all four components, the impact of the respective component on gray matter at a region strongly predicted the impact on functional connectivity at that region. Overall, our results demonstrate that ADHD involves multiple, cohesive modality spanning deficits, each one of which exhibits strong spatial overlap in the pattern of structural and functional alterations.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1523/jneurosci.3156-14.2014

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Kessler, D., Angstadt, M., Welsh, R. C., & Sripada, C.
Affiliations
University of Michigan (US)
Venue
The Journal of Neuroscience
Published
2014-12-10
Volume
34
Issue
50
Pages
16555-16566
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2147561496
Cited by
83
References
78
Citations by year
2026: 3 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 11 · 2016: 9 · 2015: 6
FWCI
6.61
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • John Templeton Foundation
  • National Institutes of Health
  • National Institute on Alcohol Abuse and Alcoholism (AA020297, K23AA020297)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
attention deficit hyperactivity disorder, default mode network, task-positive network, network segregation, functional connectivity, gray matter volume, white matter, dorsolateral prefrontal cortex, anterior cingulate cortex, dorsal attention network, cognitive control, joint independent component analysis, multimodal neuroimaging
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Brain, Child, Female, Humans, Male, Nerve Net, Echo-Planar Imaging, Young Adult, White Matter, Gray Matter

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review