Unique white matter microstructural patterns in ADHD presentations—a diffusion tensor imaging study
Open accessAbstract
Attention-deficit/hyperactivity disorder predominantly inattentive (ADHD-PI) and combined (ADHD-C) presentations are likely distinct disorders that differ neuroanatomically, neurochemically, and neuropsychologically. However, to date, little is known about specific white matter (WM) regions differentiating ADHD presentations. This study examined differences in WM microstructure using diffusion tensor imaging (DTI) data from 20 ADHD-PI, 18 ADHD-C, and 27 typically developed children. Voxel-wise analysis of DTI measurements in major fiber bundles was carried out using tract-based spatial statistics (TBSS). Clusters showing diffusivity abnormalities were used as regions of interest for regression analysis between fractional anisotropy (FA) and neuropsychological outcomes. Compared to neurotypicals, ADHD-PI children showed higher FA in the anterior thalamic radiations (ATR), bilateral inferior longitudinal fasciculus (ILF), and in the left corticospinal tract (CST). In contrast, the ADHD-C group exhibited higher FA in the bilateral cingulum bundle (CB). In the ADHD-PI group, differences in FA in the left ILF and ATR were accompanied by axial diffusivity (AD) abnormalities. In addition, the ADHD-PI group exhibited atypical mean diffusivity in the forceps minor (FMi) and left ATR and AD differences in right CB compared to healthy subjects. Direct comparison between ADHD presentations demonstrated radial diffusivity differences in FMi. WM clusters with FA irregularities in ADHD were associated with neurobehavioral performance across groups. In conclusion, differences in WM microstructure in ADHD presentations strengthen the theory that ADHD-PI and ADHD-C are two distinct disorders. Regions with WM irregularity seen in both ADHD presentations might serve as predictors of executive and behavioral functioning across groups. Hum Brain Mapp 37:3323-3336, 2016. © 2016 Wiley Periodicals, Inc.
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Increased FA has been reported in the cingulum bundle in 'combined' but not 'inattentive' types of ADHD.
“as increased FA has been reported in the cingulum bundle in ‘combined’ but not ‘inattentive’ types of ADHD (Svatkova et al., 2016; Table 2).”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Svatkova et al., 2016
The lack of reliable cingulum bundle changes in ADHD may relate to the need to separate different subtypes of ADHD.
“The lack of reliable cingulum bundle changes may relate to the need to separate different subtypes of ADHD”
From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Svatkova et al., 2016
Emerging evidence suggests that the ADHD inattentive and ADHD combined subtypes in children may be different disorders based on their unique WM microstructure.
“In addition, emerging evidence suggests that the ADHD inattentive and ADHD combined subtypes in children may be different disorders based on their unique WM microstructure [78], which was not taken into consideration in this study.”
From The brain anatomy of attention-deficit/hyperactivity disorder in young adults—a magnetic resonance imaging study (2017) · cites this paper as [78]
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BackgroundInfluentialAnterior thalamic radiation integrity in schizophrenia: A diffusion-tensor imaging study
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Altered white matter microstructure in children with attention-deficit/hyperactivity disorder
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ResultReduced white matter integrity in attention-deficit hyperactivity disorder
Hamilton, L. S., Levitt, J. G., O'Neill, J., Alger, J. R., Luders, E., Phillips, O. R., Caplan, R., Toga, A. W., McCracken, J., & Narr, K. L. (2008) · NeuroReport · doi:10.1097/wnr.0b013e3283174415 · Cited by 167 · cited 1× · see citing works
“On the contrary, higher FA values were reported in disorders with expected WM disruptions such as Williams syndrome [Hoeft et al., 2007], bipolar disorder [Yurgelun-Todd et al., 2007], and ADHD subjects [Silk et al., 2009], suggesting that increased FA might also indicate WM pathology.”
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ResultfMRI of Intrasubject Variability in ADHD: Anomalous Premotor Activity With Prefrontal Compensation
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“Previous research introduced evidence that dysfunction of motor systems may contribute to increased response variability, impaired response inhibition [Suskauer et al., 2008], and lack of attention [Kaiser et al., 2014] in children with ADHD.”
BackgroundStrategic white matter tracts for processing speed deficits in age-related small vessel disease
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“Interestingly, WM disturbances in the forceps minor have been linked with processing speed [Duering et al., 2014] that is slower in ADHD-PI individuals than in ADHD-C subjects [GothOwens et al., 2010].”
BackgroundWhite matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study
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“, 2007], bipolar disorder [Yurgelun-Todd et al., 2007], and ADHD subjects [Silk et al.”
BackgroundRegional changes in thalamic shape and volume with increasing age
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“In detail, outcomes from our study correspond with an inverse correlation of interference task and volume of bilateral thalamo-cortical projections in healthy individuals [Hughes et al., 2012].”
ResultInfluentialvan den Heuvel, M. P., de Reus, M. A., Feldman Barrett, L., Scholtens, L. H., Coopmans, F. M. T., Schmidt, R., Preuss, T. M., Rilling, J. K., & Li, L. (2015) · Human Brain Mapping · doi:10.1002/hbm.22828 · Cited by 131 · cited 1× · see citing works
“…diffusion parallel and perpendicular to the principal axon axis [Basser, 1995] and is therefore affected by degree of myelination, axonal packing and axon size, and/or coherence and co-linearity of fiber organization [Alexander et al., 2007; Mori and Zhang, 2006; van den Heuvel et al., 2015].”
BackgroundLing, J. M., Merideth, F. L., Caprihan, A., Peña, A., Teshiba, T. M., & Mayer, A. R. (2011) · Human Brain Mapping · doi:10.1002/hbm.21192 · Cited by 125 · cited 1× · see citing works
“Children in general, especially ADHD patients, are prone to movement while in the scanner that may cause bias in diffusion measurements [Ling et al., 2012].”
BackgroundAssessment of Attention Deficit Hyperactivity Disorder (ADHD) Using the BASC and BRIEF
Jarratt, K. P., Riccio, C. A., & Siekierski, B. M. (2005) · Applied Neuropsychology · doi:10.1207/s15324826an1202_4 · Cited by 125 · cited 9× · see citing works
“The ADHD groups did not differ significantly from each other on the BRIEF (P 5 0.15).”
BackgroundMethodInfluentialNeural correlates of chemotherapy-related cognitive impairment
Kaiser, J., Bledowski, C., & Dietrich, J. (2014) · Cortex · doi:10.1016/j.cortex.2014.01.010 · Cited by 117 · see citing works
Zemmoura, I., Herbet, G., Moritz-Gasser, S., & Duffau, H. (2015) · Human Brain Mapping · doi:10.1002/hbm.22766 · Cited by 115 · cited 3× · see citing works
“Surgical resection of posterior ILF portion leads to global reading impairment [Zemmoura et al., 2015] and thus disturbances of WM microstructure in ILF might potentially contribute to the learning difficulties exhibited in ADHD-PI individuals [Barkley, 2014; McBurnett et al.”
BackgroundBiederman, J., Petty, C., Ball, S. W., Fried, R., Doyle, A., Cohen, D. R., Henderson, C. S., & Faraone, S. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.09.010 · Cited by 113 · cited 1× · see citing works
“Lower IQ scores in ADHD comparing to neurotypicals are consistent with previous studies [Biederman et al., 2008, 2009].”
ResultAttentional networks and cingulum bundle in chronic schizophrenia☆
Nestor, P. G., Kubicki, M. R., Spencer, K., Niznikiewicz, M. A., McCarley, R. W., & Shenton, M. E. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.10.005 · Cited by 112 · cited 1× · see citing works
“Studies conducted with schizophrenia patients found that the FA in the left CB correlates with orienting of attention and the right CB volume is associated with reduced alertness [Nestor et al., 2007].”
BackgroundBaeyens, D., Roeyers, H., & Walle, J. V. (2006) · Child Psychiatry & Human Development · doi:10.1007/s10578-006-0011-z · Cited by 101 · cited 2× · see citing works
“There continues to be debate whether ADHD-PI and ADHD-C are distinct unassociated disorders or are variants [Baeyens et al., 2006].”
BackgroundHong, S.-B., Zalesky, A., Fornito, A., Park, S., Yang, Y.-H., Park, M.-H., Song, I.-C., Sohn, C.-H., Shin, M.-S., Kim, B.-N., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.013 · Cited by 99 · cited 5× · see citing works
“The biases introduced by anisotropic voxels are common to all groups and therefore are unlikely to provide spurious between-group results [Hong et al., 2014].”
MethodResultInfluentialDo Attention Deficits Influence IQ Assessment in Children and Adolescents with ADHD?
Jepsen, J. R. M., Fagerlund, B., & Mortensen, E. L. (2009) · Journal of Attention Disorders · doi:10.1177/1087054708322996 · Cited by 88 · cited 2× · see citing works
“In ADHD, scores are likely results of suboptimal test-taking behavior and attention problems indicative of the disease [Dennis et al., 2009; Jepsen et al., 2009; Rossi et al., 2015] and thus correction for IQ might introduce a possible bias to the findings [Dennis et al.”
ResultOertel‐Knöchel, V., Reinke, B., Alves, G. S., Jurcoane, A., Wenzler, S., Prvulovic, D., Linden, D. E. J., & Knöchel, C. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.11.004 · Cited by 85 · see citing works
A Critical Role for the Anterior Thalamus in Directing Attention to Task-Relevant Stimuli
Wright, N. F., Vann, S. D., Aggleton, J. P., & Nelson, A. J. D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4945-14.2015 · Cited by 84 · cited 1× · see citing works
“On the other hand, ADHD-PI preferentially demonstrated disturbances in fronto-striato-thalamic circuits that are implicated in cognitive control [Fair et al., 2012], processing speed [Rossi et al, 2015], and selective attention [Wright et al, 2015], indicative of ADHD-PI.”
BackgroundChiang, H., Chen, Y.-J., Lo, Y., Tseng, W. I., & Gau, S. S. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140106 · Cited by 83 · cited 2× · see citing works
“, 2012] and might represent a structural substrate of executive functions and sustained attention deficits [Chiang et al., 2015; Kubicki et al., 2003] in ADHD-C.”
BackgroundMethodKessler, D., Angstadt, M., Welsh, R. C., & Sripada, C. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3156-14.2014 · Cited by 83 · cited 1× · see citing works
“Accumulating evidence confirms impairments in baseline brain functioning in ADHD [Kessler et al., 2014].”
BackgroundPeterson, D. J., Ryan, M., Rimrodt, S. L., Cutting, L. E., Denckla, M. B., Kaufmann, W. E., & Mahone, E. M. (2011) · Journal of Child Neurology · doi:10.1177/0883073811405662 · Cited by 81 · cited 5× · see citing works
“Our study revealed higher FA values in ADHD presentations compared to neurotypicals and adds to the studies demonstrating the FA elevation to be a basis of WM alteration in ADHD [Peterson et al., 2011; Silk et al., 2009; Tamm et al., 2012].”
BackgroundResultInfluentialConnectivity supporting attention in children with attention deficit hyperactivity disorder
Barber, A. D., Jacobson, L. A., Wexler, J. L., Nebel, M. B., Caffo, B. S., Pekar, J. J., & Mostofsky, S. H. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.11.011 · Cited by 81 · cited 2× · see citing works
“In ADHD specifically, the increased antagonistic relationship between the cognitive control network (i.e., cingulo-opercular region) and the DMN was associated with improved attentional control in patients, but worse attentional control in typically developed children [Barber et al., 2015].”
BackgroundSolanto, M. V., Schulz, K. P., Fan, J., Tang, C. Y., & Newcorn, J. H. (2009) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2008.00289.x · Cited by 80 · cited 2× · see citing works
“Differences in activation during inhibition tasks [Solanto et al., 2009] or reward processing [Edel et al., 2013] in task-related fMRI studies have also been found between the groups.”
BackgroundDecreased frontostriatal microstructural organization in attention deficit/hyperactivity disorder
de Zeeuw, P., Mandl, R. C. W., Pol, H. E. H., van Engeland, H., & Durston, S. (2011) · Human Brain Mapping · doi:10.1002/hbm.21335 · Cited by 79 · cited 2× · see citing works
“…circuits with important implication in executive, social, and motivated behaviors [Masterman and Cummings, 1997]; the very areas that have been implicated in ADHD [de Zeeuw et al., 2012; Tamm et al., 2012] and other psychiatric disorders [Mamah et al., 2010; Oertel-Kn€ochel et al., 2014].”
BackgroundMetin, B., Krebs, R. M., Wiersema, J. R., Verguts, T., Gasthuys, R., van der Meere, J. J., Achten, E., Roeyers, H., & Sonuga-Barke, E. J. S. (2014) · Journal of Abnormal Psychology · doi:10.1037/abn0000013 · Cited by 78 · cited 1× · see citing works
“GEC: global executive component. r 3331 r engagement [Metin et al., 2015].”
Lawrence, K. E., Levitt, J. G., Loo, S. K., Ly, R., Yee, V., O’Neill, J., Alger, J., & Narr, K. L. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2013.01.010 · Cited by 77 · cited 4× · see citing works
“The JHU-ICBM-tract atlas [Wakana et al., 2007] was used to define regions of interest (ROI) for major fiber bundles that have previously demonstrated importance in ADHD [Chuang et al., 2013; Lawrence et al., 2013; Silk et al., 2009; Tamm et al., 2012].”
BackgroundMethodInfluentialHolzapfel, M., Barnea‐Goraly, N., Eckert, M. A., Kesler, S. R., & Reiss, A. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1764-06.2006 · Cited by 75 · cited 2× · see citing works
“Although the specific microstructural substrate of higher FA values remains debatable, it seems to be the result of compensatory mechanisms [Holzapfel et al., 2006] and/or an adaptation to poor cognitive functioning [Tuch et al.”
BackgroundDiagnostic Group Differences in Parent and Teacher Ratings on the BRIEF and Conners' Scales
Sullivan, J. R., & Riccio, C. A. (2007) · Journal of Attention Disorders · doi:10.1177/1087054707299399 · Cited by 72 · cited 1× · see citing works
“Previous research introduced evidence that dysfunction of motor systems may contribute to increased response variability, impaired response inhibition [Suskauer et al., 2008], and lack of attention [Kaiser et al., 2014] in children with ADHD.”
BackgroundTamm, L., Barnea‐Goraly, N., & Reiss, A. L. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.04.001 · Cited by 72 · cited 8× · see citing works
“Our study revealed higher FA values in ADHD presentations compared to neurotypicals and adds to the studies demonstrating the FA elevation to be a basis of WM alteration in ADHD [Peterson et al., 2011; Silk et al., 2009; Tamm et al., 2012].”
BackgroundMethodResultInfluentialGoth-Owens, T. L., Martinez-Torteya, C., Martel, M. M., & Nigg, J. T. (2010) · Child Neuropsychology · doi:10.1080/09297049.2010.485126 · Cited by 69 · see citing works
Li, Q., Sun, J., Guo, L., Zang, Y., Feng, Z., Huang, X., Yang, H., Lv, Y., Huang, M., & Gong, Q. (2010) · PubMed · Cited by 67 · see citing works
Bonath, B., Tegelbeckers, J., Wilke, M., Flechtner, H., & Krauel, K. (2016) · Journal of Attention Disorders · doi:10.1177/1087054715619682 · Cited by 61 · see citing works
Lei, D., Ma, J., Du, X., Shen, G., Jin, X., & Gong, Q. (2014) · Scientific Reports · doi:10.1038/srep06875 · Cited by 56 · cited 2× · see citing works
“One study, which estimated DTI parameters in ADHD-C and ADHD-PI separately, introduced evidence of differences in WM organization between typically developed children and the two main ADHD presentations [Lei et al., 2014].”
BackgroundResultWolf, D. G. F., Zschutschke, L., Scheurich, A., Schmitz, F., Lieb, K., Tüscher, O., & Fellgiebel, A. (2013) · Human Brain Mapping · doi:10.1002/hbm.22340 · Cited by 55 · see citing works
Structural basis of the fronto-thalamic dysconnectivity in schizophrenia: A combined DCM-VBM study
Wagner, G., Koch, K., Schachtzabel, C., Schultz, C. C., Christian Gaser, B., Reichenbach, J. R., Sauer, H., Bär, K., & Schlösser, R. G. M. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.07.010 · Cited by 46 · see citing works
Differential reward processing in subtypes of adult attention deficit hyperactivity disorder
Edel, M.-A., Enzi, B., Witthaus, H., Tegenthoff, M., Peters, S., Juckel, G., & Lissek, S. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.09.026 · Cited by 42 · cited 2× · see citing works
“Differences in activation during inhibition tasks [Solanto et al., 2009] or reward processing [Edel et al., 2013] in task-related fMRI studies have also been found between the groups.”
BackgroundChuang, T., Wu, M.-T., Huang, S.-P., Weng, M.-J., & Yang, P. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.11.008 · Cited by 40 · cited 7× · see citing works
“between attention scores, GEC, and WM structure in the left ILF detected in our study is partially consistent with relationships previously shown in ADHD adolescents [Chuang et al., 2013].”
BackgroundMethodResultInfluentialSemrud‐Clikeman, M., Fine, J. G., Bledsoe, J. C., & Zhu, D. C. (2014) · Journal of Attention Disorders · doi:10.1177/1087054714559642 · Cited by 34 · cited 1× · see citing works
“The ILF was reported substantial in semantic language functions, visual and verbal memory, and visual emotional processing [Catani et al., 2003; Mandonnet et al., 2007; Shinoura et al. 2011].”
BackgroundNezamzadeh, M., Wedeen, V. J., Wang, R., Zhang, Y., Zhan, W., Young, K., Meyerhoff, D. J., Weiner, M. W., & Schuff, N. W. (2009) · European Journal of Radiology · doi:10.1016/j.ejrad.2009.06.019 · Cited by 34 · cited 1× · see citing works
“Functionally, the CB coherence has been shown central for attention, executive functions, decision-making, and emotional control [Chen et al., 2015; Nezamzadeh et al., 2010].”
BackgroundMicrostructural abnormalities of the brain white matter in attention-deficit/hyperactivity disorder
Chen, L., Huang, X., Lei, D., He, N., Hu, X., Chen, Y., Li, Y., Zhou, J., Guo, L., Kemp, G. J., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.140199 · Cited by 27 · cited 1× · see citing works
“Functionally, the CB coherence has been shown central for attention, executive functions, decision-making, and emotional control [Chen et al., 2015; Nezamzadeh et al., 2010].”
BackgroundRight temporal lobe plays a role in verbal memory
Shinoura, N., Midorikawa, A., Kurokawa, K., Onodera, T., Tsukada, M., Yamada, R., Tabei, Y., Koizumi, T., Yoshida, M., Saito, S., et al. (2011) · Neurological Research · doi:10.1179/1743132811y.0000000005 · Cited by 19 · cited 1× · see citing works
“The ILF was reported substantial in semantic language functions, visual and verbal memory, and visual emotional processing [Catani et al., 2003; Mandonnet et al., 2007; Shinoura et al. 2011].”
BackgroundRossi, A. S. U., Moura, L. M., de Mello, C. B., de Souza, A. A. L., Muszkat, M., & Bueno, O. F. A. (2015) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2015.00122 · Cited by 18 · see citing works
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- Jones DK Knösche TR Turner R 2012 White matter integrity, fiber count, and other fallacies: The do's and don'ts of diffusion MRI Neuroimage 22846632
- Semrud-Clikeman M Pliszka SR Bledsoe J Lancaster J 2014 Volumetric MRI Differences in Treatment Naive and Chronically Treated Adolescents With ADHD-Combined Type J Atten Disord 18 511 520 22653807
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Sorted by citations
The cingulum bundle: Anatomy, function, and dysfunction
Bubb, E. J., Metzler-Baddeley, C., & Aggleton, J. P. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.008 · Cited by 740 · see citing works
Beyond stereotypes of adolescent risk taking: Placing the adolescent brain in developmental context
Römer, D., Reyna, V. F., & Satterthwaite, T. D. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.07.007 · Cited by 421 · see citing works
“…seeking makes novel and potentially risky behavior more common during adolescence, this risk taking may be motivated by a “rational calculus” (Reyna and Farley, 2006) that may be adaptive for learning that underlies brain maturation (see also Ellis et al., 2012; Luciana, 2016; Telzer, 2015).”
Gehricke, J.-G., Kruggel, F., Thampipop, T., Alejo, S. D., Tatos, E., Fallon, J., & Muftuler, L. T. (2017) · PLOS ONE · doi:10.1371/journal.pone.0175433 · Cited by 103 · see citing works
“In addition, emerging evidence suggests that the ADHD inattentive and ADHD combined subtypes in children may be different disorders based on their unique WM microstructure [78], which was not taken into consideration in this study.”
BackgroundParlatini, V., Itahashi, T., Lee, Y., Liu, S., Nguyen, T. T., Aoki, Y. Y., Forkel, S. J., Catani, M., Rubia, K., Zhou, J. H., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02173-1 · Cited by 105 · see citing works
“Cingulum bundle: Twenty-one studies in children reported tract alterations in the cingulum of ADHD patients as compared to controls [21 – 24, 34, 37 – 39, 47, 48, 50, 66, 67, 69, 78, 88, 94, 98 – 101].”
BackgroundMethodResultInfluentialSaad, J. F., Griffiths, K. R., & Korgaonkar, M. S. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2020.00031 · Cited by 98 · see citing works
White matter microstructure in children and adolescents with ADHD
Connaughton, M., Whelan, R., O’Hanlon, E., & McGrath, J. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.102957 · Cited by 64 · see citing works
Saad, J. F., Griffiths, K. R., Kohn, M. R., Clarke, S. P., Williams, L. M., & Korgaonkar, M. S. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.05.016 · Cited by 62 · see citing works
“Correspondingly, diffusion tensor imaging (DTI) studies provide further support for distinct structural and white matter connectivity disturbances between the ADHD-C and ADHD-I subtype [26-29].”
Hippocampal subfield volume changes in subtypes of attention deficit hyperactivity disorder
Al-Amin, M. M., Zinchenko, A., & Geyer, T. (2018) · Brain Research · doi:10.1016/j.brainres.2018.02.007 · Cited by 62 · see citing works
Peña, I. D., Pan, M. C., Thai, C. G., & Alisso, T. (2020) · Brain Sciences · doi:10.3390/brainsci10050292 · Cited by 63 · see citing works
Development of a computerized adaptive screening tool for overall psychopathology (“p”)
Moore, T. M., Calkins, M. E., Satterthwaite, T. D., Roalf, D. R., Rosen, A. F. G., Gur, R. C., & Gur, R. E. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.05.028 · Cited by 44 · see citing works
“…2013; Nakamae et al., 2008; Peterson et al., 2011; Wang et al., 2004), superior longitudinal fascicles (Bennett et al., 2013; Harris et al., 2008; Svatkova et al., 2016; Zou et al., 2008), and the uncinate fasciculus (Kitis et al., 2012; Konrad et al., 2010; Kubicki et al., 2002; Phan et al.,…”
BackgroundPetruso, F., Giff, A., Milano, B. A., Rossi, M. M. D., & Saccaro, L. F. (2023) · Neuronal Signaling · doi:10.1042/ns20220077 · Cited by 51 · see citing works
White matter microstructure in youth with and at risk for bipolar disorder
Linke, J. O., Stavish, C. M., Adleman, N. E., Sarlls, J. E., Towbin, K. E., Leibenluft, E., & Brotman, M. A. (2019) · Bipolar Disorders · doi:10.1111/bdi.12885 · Cited by 42 · see citing works
“Anxiety disorders 16 (44) 10 (28) N/A χ(2)(1) = 2.”
Wu, Z.-M., Llera, A., Hoogman, M., Cao, Q., Zwiers, M. P., Bralten, J., Li, A., Sun, L., Yang, L., Yang, B., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101851 · Cited by 38 · see citing works
“Previous findings of smaller FA and greater RD and MD in widespread regions including anterior thalamic radiation, and cingulum and body of the corpus callosum(van Ewijk et al., 2014; Wu et al., 2017; Svatkova et al., 2016; Onnink et al., 2015; Aoki et al., 2018) (the latter FA finding also seen in meta-analysis(Chen…”
Zhang, F., Wu, W., Ning, L., McAnulty, G., Waber, D., Gagoski, B., Sarill, K., Hamoda, H., Song, Y., Cai, W. (., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.01.006 · Cited by 37 · see citing works
“…in either left (Silk et al., 2009; Chuang et al., 2013) or right (Vance et al., 2007; O'Conaill et al., 2015) hemispheres affected in ADHD, the alterations in both hemispheres have also been reported by recent studies (Svatkova et al., 2016; Duffy et al., 2017) similar to our analysis result.”
Wu, Z.-M., Wang, P., Liu, L., Liu, J., Cao, X., Sun, L., Cao, Q., Yang, L., Wang, Y., & Yang, B. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.02.012 · Cited by 31 · see citing works
Tracking Inhibitory Control in Youth With ADHD: A Multi-Modal Neuroimaging Approach
Tremblay, L. K., Hammill, C. F., Ameis, S. H., Bhaijiwala, M., Mabbott, D., Anagnostou, E. A., Lerch, J. P., & Schachar, R. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00831 · Cited by 25 · see citing works
“A recent study divided combined-type ADHD from inattentive-type ADHD before comparing to controls, and found increases in FA in specific pathways for the subtypes, including higher FA in cingulum bundle for the combined-typed ADHD group (68).”
ResultThe structural connectome in ADHD
Bu, X., Cao, M., Huang, X., & Yong He, A. (2021) · Psychoradiology · doi:10.1093/psyrad/kkab021 · Cited by 25 · see citing works
“…anterior thalamic radiations, bilateral inferior longitudinal fasciculus, and left CST for patients in the predominantly inattentive ADHD presentation and higher FA in the bilateral cingulum bundle in those in the combined ADHD presentation compared with healthy controls (Svatkova et al. , 2016).”
Graziano, P. A., Garic, D., & Dick, A. S. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13444 · Cited by 19 · see citing works
“Thus, our results replicate, in younger children, well-established findings regarding the group differences between youth diagnosed with ADHD and TD youth (e.g. see Svatkova et al., 2016; Wu et al., 2020).”
BackgroundResultLin, L., Chen, Y., Dai, Y., Yan, Z., Zou, M., Zhou, Q., Qian, L., Cui, W., Liu, M., Zhang, H., et al. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02297-3 · Cited by 18 · see citing works
“For example, previous studies integrated tract-based spatial statistics in ADHD children have reported a variety of changes in FA values (including decreased, increased, and unchanged FA) [28–30].”
Bu, X., Yang, C., Liang, K., Lin, Q., Lu, L., Zhang, L., Li, H., Gao, Y., Tang, S., Hu, X., et al. (2020) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.190024 · Cited by 16 · see citing works
Sáenz, A. A., Schuerbeek, P. V., Baijot, S., Septier, M., Deconinck, N., Defresne, P., Delvenne, V., Passeri, G., Raeymaekers, H., Slama, H., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241856 · Cited by 17 · see citing works
Ünsel-Bolat, G., Baytunca, M. B., Kardaş, B., İpçi, M., İnci İzmir, S. B., Özyurt, O., Çallı, M. C., & Ercan, E. S. (2020) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2020.1772364 · Cited by 14 · see citing works
Alger, J. R., O’Neill, J., O’Connor, M. J., Kalender, G., Ly, R., Ng, A., Dillon, A., Narr, K. L., Loo, S. K., & Levitt, J. G. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00342-0 · Cited by 15 · see citing works
Tokariev, M., Vuontela, V., Lönnberg, P., Lano, A., Perkola, J., Wolford, E., ANDERSSON, S. M., Metsäranta, M., & Carlson, S. (2019) · Brain and Cognition · doi:10.1016/j.bandc.2019.103615 · Cited by 13 · see citing works
“Exclusion criteria for EPB children were grade III-IV intraventricular hemorrhage, white matter injury, chromosomal abnormality, global cognitive impairment, cerebral palsy, attention deficit hyperactivity disorder (ADHD), insufficient native language skills, mutism and metal in body.”
BackgroundResultInfluentialNeurocognitive Pathways in Attention-Deficit/Hyperactivity Disorder and White Matter Microstructure
Bessette, K. L., & Stevens, M. C. G. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.09.007 · Cited by 13 · see citing works
“Our lack of findings with response inhibition may also be due to specific examination of this construct rather than executive functioning more broadly, since some other studies show a negative relationship between executive functioning and FA.”
ResultMazzetti, C., Damatac, C. G., Sprooten, E., ter Huurne, N., Buitelaar, J. K., & Jensen, O. B. (2022) · Psychophysiology · doi:10.1111/psyp.14008 · Cited by 11 · see citing works
“Prior morphological analyses have shown that 322 ADHD is associated with altered shape and volume of thalamic nuclei, whose connections within 323 several cortical regions, particularly frontal areas, seem disrupted in affected children (58,59).”
BackgroundHu, R., Tan, F., Chen, W., Wu, Y., Jiang, Y., Du, W., Zuo, Y., Gao, B., Song, Q., & Miao, Y. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1237113 · Cited by 11 · see citing works
“Previous research has demonstrated an increase in AD in the right cingulum bundle (42).”
Saad, J. F., Griffiths, K. R., Kohn, M. R., Braund, T. A., Clarke, S. D., Williams, L. M., & Korgaonkar, M. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0245028 · Cited by 9 · see citing works
Effects of Recreational GHB Use and Multiple GHB-Induced Comas on Brain Structure and Impulsivity
Pereira, F. R., McMaster, M. T. B., Schellekens, A., Polderman, N., de Vries, Y. D. A. T., van den Brink, W., & van Wingen, G. A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00166 · Cited by 10 · see citing works
Anterior thalamic nuclei, but not retrosplenial cortex, lesions abolish latent inhibition in rats.
Nelson, A. J. D., Powell, A. L., Kinnavane, L., & Aggleton, J. P. (2018) · Behavioral Neuroscience · doi:10.1037/bne0000265 · Cited by 9 · see citing works
Dziemian, S., Baranczuk‐Turska, Z., & Langer, N. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02117-3 · Cited by 12 · see citing works
“dimensional representations of ADHD [34, 44] and the trivialization of incorporating in-scanner head motion as a variable of particular interest [6, 10, 48, 51].”
BackgroundVanes, L. D., Tye, C., Tournier, J.-D., Combes, A. J. E., Shephard, E., Liang, H.-L., Barker, G., Nosarti, C., & Bolton, P. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103163 · Cited by 7 · see citing works
“reported both in children (Svatkova et al., 2016) and adults (Versace et al.”
BackgroundNeuroimaging Findings in Patients with EBF3 Mutations: Report of Two Cases
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“The asymmetric development of the inferior longitudinal fasciculus has been found in ADHD, language disorders, and autism [Roine et al., 2015; Svatkova et al., 2016].”
BackgroundDutta, C. N., Christov‐Moore, L., Ombao, H., & Douglas, P. K. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.938501 · Cited by 7 · see citing works
[Research advances in pathogenesis of attention deficit hyperactivity disorder].
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Altered White-matter Tract Property in Adults with Attention-deficit Hyperactivity Disorder
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“For instance, Gonzalez-Madruga et al. reported lower FA in the left inferior longitudinal fasciculus among patients with ADHD compared to healthy controls [104], while Svatkova et al. identified higher FA in the inferior longitudinal fasciculus in ADHD cohorts compared to healthy controls [90].”
Svátková, A., Pasternak, O., Eisengart, J. B., Rudser, K. D., Bednařík, P., Mueller, B. A., Delaney, K. A., Shapiro, E., Whitley, C. B., & Nestrašil, I. (2025) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12830 · Cited by 2 · see citing works
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“These microstructural alterations directly interfere with executive control networks, correlating with lower scores on Stroop tasks and longer reaction times with higher variability during Flanker tasks (Fall et al. , 2015 ; Svatkova et al. , 2016 ).”
Influential
- Authors
- Svatkova, A., Nestrasil, I., Rudser, K., Goldenring Fine, J., Bledsoe, J., & Semrud‐Clikeman, M.
- Affiliations
- Department of Pediatrics University of Minnesota Minneapolis Minnesota
- University of Minnesota (US)
- Department of Counseling, Educational Psychology, and Special Education Michigan State University East Lansing Michigan
- University of Washington (US)
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2016-05-09
- Volume
- 37
- Issue
- 9
- Pages
- 3323-3336
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC5663221
- OpenAlex
- W2363465074
- Cited by
- 44
- References
- 91
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 5 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 6 · 2017: 3
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Advancing Translational Sciences of the National Institutes of Health Award (UL1TR000114)
- Ministry of Education, Youth and Sports of the Czech Republic (CEITEC 2020 (LQ1601))
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, white matter microstructure, fractional anisotropy, anterior thalamic radiation, inferior longitudinal fasciculus, corticospinal tract, cingulum, forceps minor, axial diffusivity, radial diffusivity, executive function, children
- MeSH terms
- Attention Deficit Disorder with Hyperactivity, Brain, Brain Mapping, Child, Female, Humans, Image Interpretation, Computer-Assisted, Male, Neural Pathways, Neuropsychological Tests, Diffusion Tensor Imaging, White Matter
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