Cited by 205Philosophy and Theoretical ScienceFunctional Brain Connectivity StudiesNeural dynamics and brain function

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Returning from Oblivion: Imaging the Neural Core of Consciousness

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Långsjö, Jaakko W., Alkire, Michael T., Kaskinoro, Kimmo, Hayama, Hiroki, Maksimow, Anu, Kaisti, Kaike K., Aalto, Sargo, Aantaa, Riku, Jääskeläinen, Satu K., Revonsuo, Antti, Scheinin, Harry·2012·The Journal of Neuroscience

DOI 10.1523/jneurosci.4962-11.2012PMC PMC6620928

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Abstract

One of the greatest challenges of modern neuroscience is to discover the neural mechanisms of consciousness and to explain how they produce the conscious state. We sought the underlying neural substrate of human consciousness by manipulating the level of consciousness in volunteers with anesthetic agents and visualizing the resultant changes in brain activity using regional cerebral blood flow imaging with positron emission tomography. Study design and methodology were chosen to dissociate the state-related changes in consciousness from the effects of the anesthetic drugs. We found the emergence of consciousness, as assessed with a motor response to a spoken command, to be associated with the activation of a core network involving subcortical and limbic regions that become functionally coupled with parts of frontal and inferior parietal cortices upon awakening from unconsciousness. The neural core of consciousness thus involves forebrain arousal acting to link motor intentions originating in posterior sensory integration regions with motor action control arising in more anterior brain regions. These findings reveal the clearest picture yet of the minimal neural correlates required for a conscious state to emerge.

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Authors: Långsjö, J. W., Alkire, M. T., Kaskinoro, K., Hayama, H., Maksimow, A., Kaisti, K. K., Aalto, S., Aantaa, R., Jääskeläinen, S. K., Revonsuo, A., & Scheinin, H.
Affiliations: University of Turku (FI)
University of California, Irvine (US)
Corresponding author: Scheinin, Harry
ORCID: Långsjö, Jaakko W.
Maksimow, Anu
Aalto, Sargo
Jääskeläinen, Satu K.
Revonsuo, Antti
Scheinin, Harry
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2012-04-04
Volume: 32
Issue: 14
Pages: 4935-4943
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4962-11.2012
PMC: PMC6620928
OpenAlex: W2107508491
Cited by: 205
References: 54
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 20 · 2018: 19 · 2017: 14 · 2016: 14 · 2015: 19 · 2014: 32 · 2013: 21 · 2012: 9
FWCI: 34.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Funders: Suomen Lääketieteen Säätiö
Academy of Finland (8111818)
Turun Yliopistollinen Keskussairaala (13323)
Topics: Social Sciences › Arts and Humanities › Philosophy › Philosophy and Theoretical Science
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: neural correlates of consciousness, anesthetic-induced unconsciousness, regional cerebral blood flow, emergence of consciousness, inferior parietal cortex, frontal cortex, arousal, motor response, sensory integration
MeSH terms: Adult, Anesthesia, General, Brain, Brain Mapping, Consciousness, Frontal Lobe, Humans, Male, Nerve Net, Neurons, Parietal Lobe, Wakefulness, Young Adult

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