Cited by 189Functional Brain Connectivity StudiesNeural dynamics and brain functionTraumatic Brain Injury Research

Neural correlates of unconsciousness in large-scale brain networks

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Mashour, George A., Hudetz, Anthony G.·2018·Trends in Neurosciences

Abstract

The biological basis of consciousness is one of the most challenging and fundamental questions in 21st century science. A related pursuit aims to identify the neural correlates and causes of unconsciousness. We review current trends in the investigation of physiological, pharmacological, and pathological states of unconsciousness at the level of large-scale functional brain networks. We focus on the roles of brain connectivity, repertoire, graph-theoretical techniques, and neural dynamics in understanding the functional brain disconnections and reduced complexity that appear to characterize these states. Persistent questions in the field, such as distinguishing true correlates, linking neural scales, and understanding differential recovery patterns, are also addressed.

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Crossref · 10.1016/j.tins.2018.01.003

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  • Increased modularity, reducing information integration capacity, is observed with anesthesia, sleep, and pathologic unconsciousness.

    “increases in modularity (which reduces the capacity for information integration [151]) observed in association with anesthesia, sleep, and pathologic unconsciousness [152].”

    From The Biology of General Anesthesia from Paramecium to Primate (2019) · cites this paper as [152]

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  1. [93]Thul A 2016 EEG entropy measures indicate decrease of cortical information processing in Disorders of Consciousness Clin Neurophysiol 127 1419 27 26480834

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Authors
Mashour, G. A., & Hudetz, A. G.
Affiliations
University of Michigan (US)
Corresponding author
Mashour, George A.
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2018-03
Volume
41
Issue
3
Pages
150-160
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2786504149
Cited by
189
References
97
Citations by year
2026: 19 · 2025: 43 · 2024: 21 · 2023: 21 · 2022: 16 · 2021: 21 · 2020: 22 · 2019: 18 · 2018: 8
FWCI
2.30
Type
journal article
Language
en
Open access
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of General Medical Sciences of the National Institutes of Health (R01GM098578, R01GM111293, R01124248, R01GM056398)
  • James S. McDonnell Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
loss of consciousness, neural correlates of consciousness, large-scale brain networks, brain connectivity, graph theory, neural dynamics, consciousness
MeSH terms
Animals, Brain, Brain Mapping, Consciousness, Electroencephalography, Humans, Neural Pathways, Unconsciousness

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