Matrix Metalloproteinase 2 (MMP2) and MMP9 Secreted by Erythropoietin-Activated Endothelial Cells Promote Neural Progenitor Cell Migration

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

Reynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Neuronal replacement from endogenous precursors in the adult brain after stroke

Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799

Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

Shen, Q., Goderie, S. K., Jin, L., Karanth, N., Sun, Y., Abramova, N. E., Vincent, P. A., Pumiglia, K. M., & Temple, S. (2004) · Science · doi:10.1126/science.1095505 · Cited by 1,574

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403

VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain

Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9369 · Cited by 1,296 · cited 1×

VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A. V., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17977 · Cited by 1,201

VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia

Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317977 · Cited by 1,189

Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway

Imitola, J., Raddassi, K., Park, K. I., Müeller, F.-J., Nieto, M., Teng, Y. D., Frenkel, D., Li, J., Sidman, R. L., Walsh, C. A., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408258102 · Cited by 1,089

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

Chaitanya, G. V., Alexander, J. S., & Babu, P. P. (2010) · Cell Communication and Signaling · doi:10.1186/1478-811x-8-31 · Cited by 955

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

Rempe, R. G., Hartz, A. M., & Bauer, B. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16655551 · Cited by 721

Diffuse glioma growth: a guerilla war

Claes, A., Idema, A. J. S., & Wesseling, P. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0293-7 · Cited by 648

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

Zhang, Z. G., & Chopp, M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70061-4 · Cited by 596

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Rosenberg, G. A. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70016-x · Cited by 594

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

Candelario‐Jalil, E., Yang, Y., & Rosenberg, G. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.025 · Cited by 537

Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies

Jurcău, A., & Simion, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010014 · Cited by 532

MMP ‐9 in translation: from molecule to brain physiology, pathology, and therapy

Vafadari, B., Salamian, A., & Kaczmarek, L. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13415 · Cited by 393

The non‐haematopoietic biological effects of erythropoietin

Arcasoy, M. O. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07014.x · Cited by 347

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

Nishijima, T., Piriz, J., Duflot, S., Fernandez, A. M., Gaitán, G., Gómez‐Pinedo, U., García‐Verdugo, J. M., Leroy, F., Soya, H., Núñez, Á., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.08.007 · Cited by 341

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333

Coupling of neurogenesis and angiogenesis after ischemic stroke

Ruan, L., Wang, B. Z., Zhuge, Q., & Jin, K. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.042 · Cited by 307

Monocyte Chemoattractant Protein-1 Plays a Critical Role in Neuroblast Migration after Focal Cerebral Ischemia

Yan, Y., Sailor, K. A., Lang, B. T., Park, S. W., Vemuganti, R., & Dempsey, R. J. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600432 · Cited by 266

Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke

Teng, H., Zhang, Z. G., Wang, L., Zhang, R. L., Zhang, L., Morris, D., Gregg, S. R., Wu, Z., Jiang, A., Lu, M., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600573 · Cited by 254

Gut microbiome response to sucralose and its potential role in inducing liver inflammation in mice

Bian, X., Chi, L., Gao, B., Tu, P., Ru, H., & Lu, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00487 · Cited by 258

Metzincin proteases and their inhibitors: foes or friends in nervous system physiology?

Rivera, S., Khrestchatisky, M., Kaczmarek, L., Rosenberg, G. A., & Jaworski, D. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3467-10.2010 · Cited by 223

Role of erythropoietin in the brain

Noguchi, C. T., Asavaritikrai, P., Teng, R., & Jia, Y. (2007) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2007.03.001 · Cited by 237

Cell migration in the normal and pathological postnatal mammalian brain

Cayre, M., Canoll, P., & Goldman, J. E. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.02.001 · Cited by 254

Emerging treatments for traumatic brain injury

Xiong, Y., Mahmood, A., & Chopp, M. (2009) · Expert Opinion on Emerging Drugs · doi:10.1517/14728210902769601 · Cited by 231

Injury and repair mechanisms in ischemic stroke: considerations for the development of novel neurotherapeutics.

Candelario‐Jalil, E. (2009) · PubMed · Cited by 219

Saccharin induced liver inflammation in mice by altering the gut microbiota and its metabolic functions

Bian, X., Tu, P., Chi, L., Gao, B., Ru, H., & Lü, K. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.04.045 · Cited by 230

Multiphasic roles for matrix metalloproteinases after stroke

ROSELL, A., & LO, E. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.001 · Cited by 215

Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke

Chopp, M., Zhang, Z. G., & Jiang, Q. (2007) · Stroke · doi:10.1161/01.str.0000250235.80253.e9 · Cited by 203

New horizons for newborn brain protection: enhancing endogenous neuroprotection

Hassell, K. J., Ezzati, M., Alconada, D. A., Hausenloy, D. J., & Robertson, N. J. (2015) · Archives of Disease in Childhood Fetal & Neonatal · doi:10.1136/archdischild-2014-306284 · Cited by 207

Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines

Barkho, B. Z., Munoz, A. E., Li, X., Li, L., Cunningham, L. A., & Zhao, X. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0519 · Cited by 201

Matrix metalloproteinase-2 and -9 as promising benefactors in development, plasticity and repair of the nervous system

Verslegers, M., Lemmens, K., Hove, I. V., & Moons, L. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.03.004 · Cited by 202

Cerebrolysin enhances neurogenesis in the ischemic brain and improves functional outcome after stroke

Zhang, C., Chopp, M., Cui, Y., Wang, L., Zhang, R., Zhang, L., Lü, M., Szalad, A., Doppler, E., Hitzl, M., et al. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22495 · Cited by 194

Endogenous Erythropoietin Signaling Is Required for Normal Neural Progenitor Cell Proliferation

Chen, Z.-Y., Asavaritikrai, P., Prchal, J. T., & Noguchi, C. T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701988200 · Cited by 184

Resveratrol neuroprotection in stroke and traumatic CNS injury

Lopez, M. S., Dempsey, R. J., & Vemuganti, R. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.009 · Cited by 172

Neurorestorative treatment of stroke: Cell and pharmacological approaches

Chen, J., & Chopp, M. (2006) · NeuroRx · doi:10.1016/j.nurx.2006.07.007 · Cited by 169

Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study

Li, L., Jiang, Q., Ding, G., Zhang, L., Zhang, Z. G., Li, Q., Panda, S., Lü, M., Ewing, J. R., & Chopp, M. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.238 · Cited by 169

Repairing brain after stroke: A review on post-ischemic neurogenesis

WILTROUT, C., Lang, B. T., Yan, Y., Dempsey, R. J., & Vemuganti, R. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.011 · Cited by 164

Vitamin D improves the angiogenic properties of endothelial progenitor cells

Grundmann, M., Haidar, M., Placzko, S., Niendorf, R., Darashchonak, N., Hubel, C. A., & von Versen‐Höynck, F. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00030.2012 · Cited by 154

Perivascular instruction of cell genesis and fate in the adult brain

Goldman, S. A., & Chen, Z. (2011) · Nature Neuroscience · doi:10.1038/nn.2963 · Cited by 156

Poststroke Neurogenesis: Emerging Principles of Migration and Localization of Immature Neurons

Ohab, J. J., & Carmichael, S. T. (2007) · The Neuroscientist · doi:10.1177/1073858407309545 · Cited by 158

Mechanisms of neuronal migration in the adult brain

Kaneko, N., Sawada, M., & Sawamoto, K. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14002 · Cited by 165

The Neural Stem Cell Line CTX0E03 Promotes Behavioral Recovery and Endogenous Neurogenesis After Experimental Stroke in a Dose-Dependent Fashion

Stroemer, P., Patel, S., Hope, A. D., Oliveira, C., Pollock, K., & Sinden, J. D. (2009) · Neurorehabilitation and neural repair · doi:10.1177/1545968309335978 · Cited by 148

Regulation of endogenous neural stem/progenitor cells for neural repair—factors that promote neurogenesis and gliogenesis in the normal and damaged brain

Christie, K. J., & Turnley, A. M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00070 · Cited by 152

Enriched environment enhances transplanted subventricular zone stem cell migration and functional recovery after stroke

Hicks, A. U., Hewlett, K. A., Windle, V., Chernenko, G. A., Ploughman, M., Jolkkonen, J., Weiss, S., & Corbett, D. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.020 · Cited by 144

Neurogenesis After Stroke: A Therapeutic Perspective

Rahman, A. A., Amruta, N., Pinteaux, E., & Bix, G. J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00841-w · Cited by 147

CD44-Epidermal Growth Factor Receptor Interaction Mediates Hyaluronic Acid-promoted Cell Motility by Activating Protein Kinase C Signaling Involving Akt, Rac1, Phox, Reactive Oxygen Species, Focal Adhesion Kinase, and MMP-2

Kim, Y., Lee, Y., Choe, J., Lee, H., Kim, Y., & Jeoung, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708319200 · Cited by 141

Neural Progenitor Cells Treated with EPO Induce Angiogenesis through the Production of Vegf

Wang, L., Chopp, M., Gregg, S. R., Zhang, R. L., Teng, H., Jiang, A., Feng, Y., & Zhang, Z. G. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.32 · Cited by 136

Axonal Outgrowth and Dendritic Plasticity in the Cortical Peri-Infarct Area After Experimental Stroke

Ueno, Y., Chopp, M., Zhang, L., Buller, B., Liu, Z., Lehman, N. L., Liu, X., Zhang, Y., Roberts, C. J., & Zhang, Z. G. (2012) · Stroke · doi:10.1161/strokeaha.111.646224 · Cited by 134

Erythropoietin Sustains Cognitive Function and Brain Volume after Neonatal Stroke

Gonzalez, F. F., Abel, R., Almli, C. R., Mu, D., Wendland, M. F., & Ferriero, D. M. (2009) · Developmental Neuroscience · doi:10.1159/000232558 · Cited by 132

Chapter 26 Role of Akt and Erk Signaling in the Neurogenesis Following Brain Ischemia

Shioda, N., Han, F., & Fukunaga, K. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85026-5 · Cited by 132

Zinc in the Brain: Friend or Foe?

Choi, S., Hong, D. K., Choi, B. Y., & Suh, S. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238941 · Cited by 140

Neuroblast Division during Migration toward the Ischemic Striatum: A Study of Dynamic Migratory and Proliferative Characteristics of Neuroblasts from the Subventricular Zone

Zhang, R. L., LeTourneau, Y., Gregg, S. R., Wang, Y., Toh, Y., Robin, A. M., Zhang, Z. G., & Chopp, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4969-06.2007 · Cited by 133

Erythropoietin: Emerging Role of Erythropoietin in Neonatal Neuroprotection

Rangarajan, V., & Juul, S. E. (2014) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2014.06.008 · Cited by 129

Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism

Zhang, Y., Wang, L., Dey, S., Alnaeeli, M., Suresh, S., Rogers, H. M., Teng, R., & Noguchi, C. T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150610296 · Cited by 132

Stem cell therapy in stroke

Locatelli, F., Bersano, A., Ballabio, E., Lanfranconi, S., Papadimitriou, D. A., Strazzer, S., Bresolin, N., Comi, G. P., & Corti, S. P. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8346-1 · Cited by 125

Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse

Zhang, R. L., Chopp, M., Gregg, S. R., Toh, Y., Roberts, C., LeTourneau, Y., Buller, B., Jia, L., Davarani, S. P. N., & Zhang, Z. G. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.55 · Cited by 120

Matrix metalloproteinases as drug targets in ischemia/reperfusion injury

Dejonckheere, E., Vandenbroucke, R. E., & Libert, C. (2011) · Drug Discovery Today · doi:10.1016/j.drudis.2011.06.009 · Cited by 120

Diverse Roles of the Vasculature within the Neural Stem Cell Niche

Goldberg, J. S., & Hirschi, K. K. (2009) · Regenerative Medicine · doi:10.2217/rme.09.61 · Cited by 119

Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Epoch

Carmichael, S. T. (2008) · Stroke · doi:10.1161/strokeaha.107.499962 · Cited by 118

Human Muller Stem Cell (MIO-M1) Transplantation in a Rat Model of Glaucoma: Survival, Differentiation, and Integration

Bull, N. D., Limb, G. A., & Martin, K. R. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1770 · Cited by 116

Survival and proliferative roles of erythropoietin beyond the erythroid lineage

Noguchi, C. T., Wang, L., Rogers, H. M., Teng, R., & Jia, Y. (2008) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399408000860 · Cited by 113

Experimental models, neurovascular mechanisms and translational issues in stroke research

Lo, E. H. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707626 · Cited by 110

PRL1 Promotes Cell Migration and Invasion by Increasing MMP2 and MMP9 Expression through Src and ERK1/2 Pathways

Luo, Y., Liang, F., & Zhang, Z. (2009) · Biochemistry · doi:10.1021/bi8020789 · Cited by 111

Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies

Chopp, M., Li, Y., & Zhang, Z. G. (2008) · Stroke · doi:10.1161/strokeaha.108.533141 · Cited by 117

Platelet-Rich Plasma (PRP) Promotes Fetal Mesenchymal Stem/Stromal Cell Migration and Wound Healing Process

Roubelakis, M. G., Trohatou, O., Roubelakis, A., Mili, E., Kalaitzopoulos, I., Papazoglou, G., Pappa, K. I., & Anagnou, N. P. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-013-9494-8 · Cited by 112

Early Beneficial Effect of Matrix Metalloproteinase Inhibition on Blood—Brain Barrier Permeability as Measured by Magnetic Resonance Imaging Countered by Impaired Long-Term Recovery after Stroke in Rat Brain

Sood, R., Taheri, S., Candelario‐Jalil, E., Estrada, E. Y., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600534 · Cited by 108

Erythropoietin Amplifies Stroke-Induced Oligodendrogenesis in the Rat

Zhang, L., Chopp, M., Zhang, R. L., Wang, L., Zhang, J., Wang, Y., Toh, Y., Santra, M., Lü, M., & Zhang, Z. G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011016 · Cited by 108

Angiopoietin 2 Mediates the Differentiation and Migration of Neural Progenitor Cells in the Subventricular Zone after Stroke

Liu, X., Chopp, M., Zhang, R. L., Hozeska‐Solgot, A., Gregg, S. R., Buller, B., Lü, M., & Zhang, Z. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.006551 · Cited by 104

New possibilities for neuroprotection in neonatal hypoxic-ischemic encephalopathy

Victor, S., Rocha‐Ferreira, E., Rahim, A. A., Hagberg, H., & Edwards, A. D. (2021) · European Journal of Pediatrics · doi:10.1007/s00431-021-04320-8 · Cited by 101

Erythropoietin: a multimodal neuroprotective agent

Byts, N., & Sirén, A. (2009) · Experimental & Translational Stroke Medicine · doi:10.1186/2040-7378-1-4 · Cited by 98

Phosphodiesterase-5 is a therapeutic target for peripheral neuropathy in diabetic mice

Wang, L., Chopp, M., Szalad, A., Liu, Z., Bolz, M., Ãlvarez, F. M., Lu, M., Zhang, L., Cui, Y., Zhang, R. L., et al. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.039 · Cited by 97

Neural Stem Cell Niches in Health and Diseases

Decimo, I., Bifari, F., Krampera, M., & Fumagalli, G. F. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212799859611 · Cited by 102

Blood‐brain barrier development: Systems modeling and predictive toxicology

Saili, K. S., Zurlinden, T. J., Schwab, A. J., Silvin, A., Baker, N., Hunter, E. S., Ginhoux, F., & Knudsen, T. B. (2017) · Birth Defects Research · doi:10.1002/bdr2.1180 · Cited by 101

The Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarction

Koh, S., & Lo, E. H. (2015) · Journal of Clinical Neurology · doi:10.3988/jcn.2015.11.4.297 · Cited by 95

Role of neural precursor cells in promoting repair following stroke

Dibajnia, P., & Morshead, C. M. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.107 · Cited by 98

Interaction of Inflammation and Hyperoxia in a Rat Model of Neonatal White Matter Damage

Brehmer, F., Bendix, I., Prager, S., van de Looij, Y., Reinboth, B. S., Zimmermanns, J., Schlager, G. W., Brait, D., Sifringer, M., Endesfelder, S., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049023 · Cited by 92

The role of miR-146a in dorsal root ganglia neurons of experimental diabetic peripheral neuropathy

Wang, L., Chopp, M., Szalad, A., Zhang, Y., Wang, X., Zhang, R. L., Liu, X., Jia, L., & Zhang, Z. G. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.057 · Cited by 87

Matrix Metalloproteinase (MMP)-9 Induced by Wnt Signaling Increases the Proliferation and Migration of Embryonic Neural Stem Cells at Low O2 Levels

Ingraham, C. A., Park, G. C., Makarenkova, H. P., & Crossin, K. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.229427 · Cited by 88

Nitric Oxide Donor Upregulation of Stromal Cell-Derived Factor-1/Chemokine (CXC Motif) Receptor 4 Enhances Bone Marrow Stromal Cell Migration into Ischemic Brain After Stroke

Cui, X., Chen, J., Zacharek, A., Li, Y., Roberts, C. J., Kapke, A., Savant‐Bhonsale, S., & Chopp, M. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0169 · Cited by 87

Chronic neuroinflammation impacts the recruitment of adult-born neurons into behaviorally relevant hippocampal networks

Bélarbi, K., Arellano, C., Ferguson, R. A., Jopson, T. D., & Rosi, S. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.07.225 · Cited by 90

Combination of tissue-plasminogen activator with erythropoietin induces blood–brain barrier permeability, extracellular matrix disaggregation and DNA fragmentation after focal cerebral ischemia in mice

Zechariah, A., ElAli, A., & Hermann, D. M. (2010) · Stroke · doi:10.1161/strokeaha.109.574418 · Cited by 84

Neural precursor cells in the ischemic brain – integration, cellular crosstalk, and consequences for stroke recovery

Hermann, D. M., Peruzzotti‐Jametti, L., Schlechter, J., Bernstock, J. D., Doeppner, T. R., & Pluchino, S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00291 · Cited by 84

Adult Neural Stem Cells: Response to Stroke Injury and Potential for Therapeutic Applications

Barkho, B. Z., & Zhao, X. (2011) · Current Stem Cell Research & Therapy · doi:10.2174/157488811797904362 · Cited by 86

Erythropoietin: Powerful protection of ischemic and post-ischemic brain

Nguyen, A. Q., Cherry, B., Scott, G. F., Ryou, M., & Mallet, R. T. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370214523703 · Cited by 82

Erythropoietin neuroprotection with traumatic brain injury

Ponce, L. L., Navarro, J. C., Ahmed, O., & Robertson, C. S. (2012) · Pathophysiology · doi:10.1016/j.pathophys.2012.02.005 · Cited by 82

Therapeutic strategies for inhibiting invasion in glioblastoma

Drappatz, J., Norden, A. D., & Wen, P. Y. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.10 · Cited by 80

Increase in neurogenesis and neuroblast migration after a small intracerebral hemorrhage in rats

Masuda, T., Isobe, Y., Aihara, N., Furuyama, F., Misumi, S., Kim, T., Nishino, H., & Hida, H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.08.039 · Cited by 80

Endothelial cells promote migration and proliferation of enteric neural crest cells via β1 integrin signaling

Nagy, N., Mwizerwa, O., Yaniv, K., Carmel, L., Pieretti‐Vanmarcke, R., Weinstein, B. M., & Goldstein, A. M. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.03.025 · Cited by 85

Metformin treatment alleviates polycystic ovary syndrome by decreasing the expression of MMP‐2 and MMP‐9 via H19/miR‐29b‐3p and AKT/mTOR/autophagy signaling pathways

Chen, Z., Wei, H., Zhao, X., Xin, X., Peng, L., Ning, Y., Wang, Y., Lan, Y., & Zhang, Q. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28594 · Cited by 79

A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo

Chen, L., Zhang, K., Shi, Z., Zhang, A., Jia, Z., Wang, G., Pu, P., Kang, C., & Han, L. (2014) · Oncology Reports · doi:10.3892/or.2014.3012 · Cited by 79

EGCG Inhibits Proliferation, Invasiveness and Tumor Growth by Up-Regulation of Adhesion Molecules, Suppression of Gelatinases Activity, and Induction of Apoptosis in Nasopharyngeal Carcinoma Cells

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