The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Alexander Disease
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### Introduction The past decade has witnessed a burst of speculation and data about how astrocyte dysfunction contributes to the phenotypes of the well known neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis, as well as other types of
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“Astrocytes may also exhibit cell-autonomous disturbances8, as happens in astrocytopathies resulting from mutated alleles of astrocytic genes (for example, GFAP in Alexander disease)9, as well as from direct viral infections or exposure to toxic substances that specifically damage astrocytes (for example, ammonium in hepatic encephalopathy)10.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [9]
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β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518
New roles for astrocytes: redefining the functional architecture of the brain.
Nedergaard, M., Ransom, B., & Goldman, S. A. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.008 · Cited by 1,334 · cited 1×
“On the other hand, white matter astrocytes provide critical metabolic support to oligodendrocytes, which are dependent upon astroglial lactate for their homeostatic maintenance, and astrocytic exchangers for interstitial ion homeostasis (Nedergaard et al., 2003).”
BackgroundSelf-citationA Structural Scaffolding of Intermediate Filaments in Health and Disease
Fuchs, E. V., & Cleveland, D. W. (1998) · Science · doi:10.1126/science.279.5350.514 · Cited by 1,013
Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease
Brenner, M., Johnson, T., Boespflug‐Tanguy, O., Rodriguez, D., Goldman, J. E., & Messing, A. (2001) · Nature Genetics · doi:10.1038/83679 · Cited by 698
Self-citationSheldon, A. L., & Robinson, M. B. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.03.012 · Cited by 593
αB-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain
Iwaki, T., Kume-Iwaki, A., Liem, R. K. H., & Goldman, J. E. (1989) · Cell · doi:10.1016/0092-8674(89)90173-6 · Cited by 549
Self-citationVesicular release of glutamate from unmyelinated axons in white matter
Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 488
Role of plectin in cytoskeleton organization and dynamics
Wiche, G. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.17.2477 · Cited by 423
Buffo, A., Rolando, C., & Ceruti, S. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.09.014 · Cited by 338
Alexander disease: diagnosis with MR imaging.
van der Knaap, M. S., Naidu, S., Breiter, S. N., Blasér, S., Stroink, H., Springer, S., Begeer, J. C., Coster, R. V., Barth, P. G., Thomas, N. H., et al. (2001) · PubMed Central · Cited by 338
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- Rosenthal, 1898, Über eine eigenthümliche, mit syringomyelie complicirte geschwulst des rückenmarks, Bietr Pathol Anat, 23, 111
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Kang, J. H., Hong, S. J., & Kim, D. K. (2013) · Journal of genetic medicine · doi:10.5734/jgm.2013.10.2.88 · Cited by 1
Goldman, J. E., & Feany, M. Β. (2018) · doi:10.1002/9781119013112.ch37 · Cited by 1
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Inoue, K. (2015) · Springer eBooks · doi:10.1007/978-4-431-54541-5_6
Lázaro Luís Faria do Amaral, Kelly Fiorini, Asim K. Bag, Leonardo Furtado Freitas
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An infant form of Alexander disease (a clinical case and literature review)
Vasin, R. A., Krasnikov, M. A., & Vasina, S. V. (2016) · Burdenko s Journal of Neurosurgery · doi:10.17116/neiro201680693-98
Sabetrasekh, P., Alper, G. P., & Vanderver, A. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-61407-6_17
Childhood Neurodegenerative Disorders
Nair, L. D. V. (2018) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-5282-6.ch018
Serrano, S. (2006) · Cuadernos hispanoamericanos
(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-37754-6.50249-9
Neuro-Ophthalmologic Manifestations of Neurodegenerative Disease in Childhood
Brodsky, M. C. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3384-6_10
Sames, L., Moore, A. T., Arnold, R. J. G., & Ekins, S. (2014) · F1000Research · doi:10.12688/f1000research.4019
(2016) · Elsevier eBooks · doi:10.1016/b978-0-323-44781-2.50167-4
Sames, L., Moore, A., Arnold, R. J. G., & Ekins, S. (2014) · F1000Research · doi:10.12688/f1000research.4270
Teaching Neuro Images : Late-onset Alexander disease
Lee, K., Moon, J., & Lee, S. (2023) · Neurology · doi:10.1212/wnl.0000000000207010
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00018-3
Verkhratsky, A., & Butt, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821565-4.00005-5
Authors’ response to: “Alexander disease genetics: Beyond GFAP exon sequencing?”
Alexander, A. L., Lim, S. Y., Massingham, L. J., Phillips, O. W., Chambers, M., & Donahue, J. E. (2023) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlad101
Alexander Disease: Scientific Advancement and Therapeutic Intervention in Rare Disease Research
Reddy, A., & Erler, J. A. (2023) · Journal of Student Research · doi:10.47611/jsrhs.v12i4.5764
Type III intermediate filaments As novel CoAlation targets
Goya‐Iglesias, N., Yu, B. Y. K., Gout, I. T., & Pérez‐Sala, D. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.080
Disorders with prominent posterior fossa involvement
Ayrignac, X. (2024) · Handbook of clinical neurology · doi:10.1016/b978-0-323-99209-1.00007-7
Establishment and Use of Primary Cultured Astrocytes from Alexander Disease Model Mice
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Bilateral vestibulopathy in Alexander disease type II– a case report
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Schwarz, S., Steggerda, S. J., de Vries, L. S., Schulz, K., Dürr, N. R., Lequin, M. H., Rosenbaum, T., Felderhoff‐Müser, U., Jauss, R., Nuñez, F. B., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6572580/v1
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Dykstra, W., Matusova, Z., Battaglia, R. A., Abaffy, P., Goya‐Iglesias, N., Pérez‐Sala, D., Ahlenius, H., Kubista, M., Pasterkamp, R. J., Li, L., et al. (2025) · Glia · doi:10.1002/glia.70049
Astrogliopathology: A core pathogenic factor in diabetic neuropathic pain
Wang, B. Y., Xie, Y., Zheng, X., & Zhang, J. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.08.010 · Cited by 2
Malakar, S., Das, T., Halder, T., Yadav, V., Sahu, A., & Das, P. (2025) · Gene Reports · doi:10.1016/j.genrep.2025.102393
Plug, B. C., Revers, I. M., Breur, M., González, G. M., Timmerman, J. A., Meijns, N., Hamberg, D., Wagendorp, J., Nutma, E., Wolf, N. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728201
Plug, B. C., Revers, I. M., Breur, M., González, G. M., Timmerman, J. A., Meijns, N., Hamberg, D., Wagendorp, J., Nutma, E., Wolf, N. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728192
Plug, B. C., Revers, I. M., Breur, M., González, G. M., Timmerman, J. A., Meijns, N., Hamberg, D., Wagendorp, J., Nutma, E., Wolf, N. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728189
Plug, B. C., Revers, I. M., Breur, M., González, G. M., Timmerman, J. A., Meijns, N., Hamberg, D., Wagendorp, J., Nutma, E., Wolf, N. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728198
Plug, B. C., Revers, I. M., Breur, M., González, G. M., Timmerman, J. A., Meijns, N., Hamberg, D., Wagendorp, J., Nutma, E., Wolf, N. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728204
Plug, B. C., Revers, I. M., Breur, M., González, G. M., Timmerman, J. A., Meijns, N., Hamberg, D., Wagendorp, J., Nutma, E., Wolf, N. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728186
Plug, B. C., Revers, I. M., Breur, M., González, G. M., Timmerman, J. A., Meijns, N., Hamberg, D., Wagendorp, J., Nutma, E., Wolf, N. I., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26728183
Yamazaki, Y., Fujiwara, H., Goto, J., & Tanaka, K. F. (2026) · Neuroscience Letters · doi:10.1016/j.neulet.2026.138511
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Krohn, J., Breuer, L., Wegmann, S., & Dean, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.19.712916
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Self-citationHernández-Gerez, E., Goya‐Iglesias, N., Viedma-Poyatos, Á., Pajares, M. A., & Pérez‐Sala, D. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.280 · Cited by 1
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Cullen, J. S., Russell, J. A., Kelm‐Nelson, C. A., Szot, J. C., Messing, A., Hagemann, T. L., & Connor, N. P. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116359
Self-citationFang, J. G., Wang, Z., Feng, T., & Jiang, Y. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15145677
Menacho-Román, M., Rodríguez, A. M., Alonso, J. R. P., Heras, I. P. D. L., Bártulos, A. V., & Arribas-Gómez, I. (2026) · The Journal of Applied Laboratory Medicine · doi:10.1093/jalm/jfag110
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Steger, L., Rothhammer, V., & Zunke, F. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06142-x
Gene therapy in leukodystrophies
Vafadar, A., Heidari, Z., & Savardashtaki, A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40467-2.00010-5
Hillen, A. E. J., Capuano, I., Gega, B., Norata, R., Mombled, M., Laface, I., Zambonini, G., Lomagno, A., Rouillon, M., Giannelli, S. G., et al. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.09.019
Srivastava, D. S. K., Abdullah, D., Rehman, M., & Atif, D. H. (2026) · PAIN JOINTS SPINE · doi:10.1922/pjs.16.5s.2026.1119
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Metadata
- Authors
- Messing, A., Brenner, M., Feany, M. B., Nedergaard, M., & Goldman, J. E.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Alabama at Birmingham (US)
- University of Rochester Medicine (US)
- Columbia University (US)
- Corresponding author
- Messing, Albee
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-04-11
- Volume
- 32
- Issue
- 15
- Pages
- 5017-5023
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3336214
- OpenAlex
- W4251359871
- Cited by
- 250
- References
- 55
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 21 · 2023: 17 · 2022: 17 · 2021: 21 · 2020: 11 · 2019: 17 · 2018: 18 · 2017: 15 · 2016: 24 · 2015: 19 · 2014: 19 · 2013: 17 · 2012: 1
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS060120, NS-42803, NS 22475, R01NS022475, P01NS042803, NS-060120)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 03352, P01HD076892, R03HD046599, P30HD003352)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- Alexander disease, astrocyte dysfunction, neurodegenerative diseases, astrocytes, neuroinflammation
- MeSH terms
- Animals, Astrocytes, Brain, Disease Models, Animal, Glial Fibrillary Acidic Protein, Humans, Models, Neurological, Neural Pathways, Age of Onset, Alexander Disease
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