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Alexander Disease
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### Introduction The past decade has witnessed a burst of speculation and data about how astrocyte dysfunction contributes to the phenotypes of the well known neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis, as well as other types of
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“Astrocytes may also exhibit cell-autonomous disturbances8, as happens in astrocytopathies resulting from mutated alleles of astrocytic genes (for example, GFAP in Alexander disease)9, as well as from direct viral infections or exposure to toxic substances that specifically damage astrocytes (for example, ammonium in hepatic encephalopathy)10.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [9]
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Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease
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Metadata
- Authors
- Messing, A., Brenner, M., Feany, M. B., Nedergaard, M., & Goldman, J. E.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Alabama at Birmingham (US)
- University of Rochester Medicine (US)
- Columbia University (US)
- Corresponding author
- Messing, Albee
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-04-11
- Volume
- 32
- Issue
- 15
- Pages
- 5017-5023
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3336214
- OpenAlex
- W4251359871
- Cited by
- 250
- References
- 55
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 21 · 2023: 17 · 2022: 17 · 2021: 21 · 2020: 11 · 2019: 17 · 2018: 18 · 2017: 15 · 2016: 24 · 2015: 19 · 2014: 19 · 2013: 17 · 2012: 1
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS060120, NS-42803, NS 22475, R01NS022475, P01NS042803, NS-060120)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 03352, P01HD076892, R03HD046599, P30HD003352)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- Alexander disease, astrocyte dysfunction, neurodegenerative diseases, astrocytes, neuroinflammation
- MeSH terms
- Animals, Astrocytes, Brain, Disease Models, Animal, Glial Fibrillary Acidic Protein, Humans, Models, Neurological, Neural Pathways, Age of Onset, Alexander Disease
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