Cited by 210Muscle Physiology and DisordersNerve injury and regenerationNeurogenetic and Muscular Disorders Research

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BDNF Is Expressed in Skeletal Muscle Satellite Cells and Inhibits Myogenic Differentiation

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Mousavi, Kambiz, Jasmin, Bernard J.·2006·The Journal of Neuroscience

DOI 10.1523/jneurosci.5398-05.2006PMC PMC6675269

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Abstract

In skeletal muscle, brain-derived neurotrophic factor (BDNF) has long been thought to serve as a retrograde trophic factor for innervating motor neurons throughout their lifespan. However, its localization in mature muscle fibers has remained elusive. Given the postulated roles of BDNF in skeletal muscle, we performed a series of complementary experiments aimed at defining the localization of BDNF and its transcripts in adult muscle. By reverse transcription-PCR, in situ hybridization, and immunofluorescence, we show that BDNF, along with the receptor p75 NTR , is not expressed at significant levels within mature myofibers and that it does not accumulate preferentially within subsynaptic regions of neuromuscular junctions. Interestingly, expression of BDNF correlated with that of Pax3, a marker of muscle progenitor cells, in several different adult skeletal muscles. Additionally, BDNF was expressed in Pax7+ satellite cells where it colocalized with p75 NTR . In complementary cell culture experiments, we detected high levels of BDNF and p75 NTR in myoblasts. During myogenic differentiation, expression of BDNF became drastically reduced. Using small interfering RNA (siRNA) technology to knock down BDNF expression, we demonstrate enhanced myogenic differentiation of myoblasts. This accelerated rate of myogenic differentiation seen in myoblasts expressing BDNF siRNA was normalized by administration of recombinant BDNF. Collectively, these findings show that BDNF plays an important regulatory function during myogenic differentiation. In addition, the expression of BDNF in satellite cells is coherent with the notion that BDNF serves a key role in maintaining the population of muscle progenitors in adult muscle.

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“Accordingly, via binding to its receptors tyrosine receptor kinase B (TrkB) and/or p75 NTR, BDNF initiates intracellular events central to neuronal development and maturation (Huang and Reichardt, 2003; Nykjaer et al., 2005).”
Background
Pax7 Is Required for the Specification of Myogenic Satellite Cells
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“To identify skeletal muscle satellite cells in these experiments, we used an antibody directed against Pax7, a paralog of Pax3, which has recently been shown to be expressed in all skeletal muscle-derived Pax3 cells (Seale et al., 2000; Montarras et al., 2005).”
Method
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Authors: Mousavi, K., & Jasmin, B. J.
Affiliations: University of Ottawa (CA)
Corresponding author: Jasmin, Bernard J.
ORCID: Jasmin, Bernard J.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2006-05-24
Volume: 26
Issue: 21
Pages: 5739-5749
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5398-05.2006
PMC: PMC6675269
OpenAlex: W2029048316
Cited by: 210
References: 58
Citations by year: 2026: 10 · 2025: 16 · 2024: 20 · 2023: 9 · 2022: 20 · 2021: 13 · 2020: 11 · 2019: 11 · 2018: 9 · 2017: 11 · 2016: 14 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 3
FWCI: 1.63
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Health Sciences › Medicine › Genetics (clinical) › Neurogenetic and Muscular Disorders Research
Keywords: brain-derived neurotrophic factor, skeletal muscle satellite cells, myogenesis, p75 neurotrophin receptor, Pax3, Pax7, muscle progenitor cells, myoblasts, neuromuscular junction, muscle regeneration
MeSH terms: Animals, Cell Differentiation, Cells, Cultured, Female, Tissue Distribution, Rats, Sprague-Dawley, Muscle, Skeletal, Brain-Derived Neurotrophic Factor, Receptor, Nerve Growth Factor, Satellite Cells, Skeletal Muscle, Rats

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BDNF Is Expressed in Skeletal Muscle Satellite Cells and Inhibits Myogenic Differentiation

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