Functional Connectivity of the Striatum Links Motivation to Action Control in Humans
Open accessAbstract
Motivation improves the efficiency of intentional behavior, but how this performance modulation is instantiated in the human brain remains unclear. We used a reward-cued antisaccade paradigm to investigate how motivational goals (the expectation of a reward for good performance) modulate patterns of neural activation and functional connectivity to improve preparation for antisaccade performance. Behaviorally, subjects performed better (faster and more accurate antisaccades) when they knew they would be rewarded for good performance. Reward anticipation was associated with increased activation in the ventral and dorsal striatum, and cortical oculomotor regions. Functional connectivity between the caudate nucleus and cortical oculomotor control structures predicted individual differences in the behavioral benefit of reward anticipation. We conclude that although both dorsal and ventral striatal circuitry are involved in the anticipation of reward, only the dorsal striatum and its connected cortical network is involved in the direct modulation of oculomotor behavior by motivational incentive.
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Networks associated with attention and dopamine release were largely segregated during control trials but less segregated during reward trials.
“they showed that while those networks were largely segregated during control trials (i.e., they exhibited high within-network connectivity), there was less segregation (i.e., higher between-network connectivity) during reward trials (Harsay et al., 2011; Kinnison, Padmala, Choi, & Pessoa, 2012).”
From Selection history: How reward modulates selectivity of visual attention. (2018) · cites this paper as Harsay et al., 2011
The ‘Functional connectivity between striatal and cortical regions’ section (page not provided) reports higher connectivity between the caudate and oculomotor-control regions during reward anticipation than during no-reward anticipation. It does not report high within-network connectivity or establish that attention and dopamine-release networks were largely segregated during control trials; dopamine release was not measured. (LLM, conf=0.84)
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- Authors
- Harsay, H. A., Cohen, M. X., Oosterhof, N. N., Forstmann, B. U., Mars, R. B., & Ridderinkhof, K. R.
- Affiliations
- University of Amsterdam (NL)
- University of Arizona (US)
- Bangor University (GB)
- Spinoza Centre for Neuroimaging (NL)
- University of Oxford (GB)
- Corresponding author
- Ridderinkhof, K. R.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-07-20
- Volume
- 31
- Issue
- 29
- Pages
- 10701-10711
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6622616
- OpenAlex
- W2107219405
- Cited by
- 75
- References
- 68
- Citations by year
- 2026: 6 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 8 · 2016: 2 · 2015: 6 · 2014: 13 · 2013: 8 · 2012: 8
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- motivation, reward anticipation, functional connectivity, striatum, dorsal striatum, ventral striatum, caudate nucleus, antisaccade task, oculomotor control, action control, individual differences
- MeSH terms
- Analysis of Variance, Attention, Basal Ganglia, Brain Mapping, Caudate Nucleus, Cues, Eye Movements, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motivation, Neural Pathways, Oxygen, Photic Stimulation, Reaction Time, Reward, Serial Learning, Time Factors, Young Adult
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