Executive control of countermanding saccades by the supplementary eye field
Abstract
The supplementary eye field registers the occurrence of conflict, errors and reward in macaque monkeys performing a saccade-countermanding task. Using intracortical microstimulation, we determined whether the supplementary eye field only monitors or can actually influence performance. Weak microstimulation of many sites in the supplementary eye field improved monkeys' performance on a 'stop signal' task by delaying saccade initiation. This effect depended on the context of the task because simple visually guided saccades were not delayed by the same stimulation. These results demonstrate that the supplementary eye field can exert contextual executive control over saccade generation.
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In monkeys, oculomotor response inhibition may be regulated by the supplementary eye field, which can inhibit the initiation of eye movements.
“In monkeys, oculomotor response inhibition may be regulated by a specific prefrontal cortical area, the supplementary eye field, that can inhibit the initiation of eye movements [65].”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [65]
Several studies indicate that people proactively alter response strategies when they anticipate stop signals, sacrificing go-task speed for stop-task success.
“Several studies suggest that subjects change response strategies proactively when they expect stop signals to occur, trading speed in the go task for success in the stop task [2, 7].”
From Response inhibition in the stop-signal paradigm (2008) · cites this paper as [7]
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- Authors
- Stuphorn, V., & Schall, J. D.
- Affiliations
- Johns Hopkins University (US)
- Vanderbilt University (US)
- Corresponding author
- Stuphorn, Veit
- Venue
- Nature Neuroscience
- Published
- 2006-05-28
- Volume
- 9
- Issue
- 7
- Pages
- 925-931
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2134718932
- Cited by
- 222
- References
- 45
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 11 · 2016: 13 · 2015: 17 · 2014: 15 · 2013: 18 · 2012: 20
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vanderbilt University
- Deutsche Forschungsgemeinschaft
- National Institutes of Health
- National Institute of Mental Health (R01MH055806, R01-MH55806)
- National Eye Institute (P30-EY08126, P30EY008126)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD015052)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- supplementary eye field, stop-signal task, executive function, saccade initiation, intracortical microstimulation, error monitoring, conflict detection, reward processing, macaque, visually guided saccades
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Brain Mapping, Electric Stimulation, Eye, Frontal Lobe, Functional Laterality, Macaca radiata, Male, Neural Inhibition, Neurons, Reaction Time, Saccades, Sensory Thresholds, Visual Fields
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