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A Role for Non-Rapid-Eye-Movement Sleep Homeostasis in Perceptual Learning
Open accessAbstract
Slow-wave activity (SWA; EEG power density in the 0.75–4.5 Hz range) in non-rapid-eye-movement (NREM) sleep is the primary marker of sleep homeostasis and thought to reflect sleep need. But it is unknown whether the generation of SWA itself serves a fundamental function. Previously, SWA has been implicated in brain plasticity and learning, yet the evidence for a causal role remains correlative. Here, we used acoustic slow-wave suppression to test whether overnight improvement in visual texture discrimination, a form of perceptual learning, directly depends on SWA during sleep. Two groups of subjects were trained on a texture discrimination task (TDT) after baseline sleep, and were tested 24 h later, after a 4 h experimental (EX) sleep episode (with or without SWA suppression), and again after a night of recovery sleep. In the suppression group, SWA during EX sleep was reduced by 30% compared with the control group, whereas total sleep time and REM sleep were not affected. Texture discrimination improved after EX sleep in the control group but not in the suppression group. Moreover, overnight improvement in TDT performance correlated with EEG power density during NREM sleep in the frequency range of SWA (maximum r= 0.75 at 0.75–1.0 Hz) over brain areas involved in TDT learning. We conclude that SWA is an important determinant of sleep-dependent gains in perceptual performance, a finding that directly implicates processes of sleep homeostasis in learning.
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“This type of stimulation applied during early non-REM sleep specifically enhanced Ͻ1 Hz slow oscillations and additionally increased frontal slow spindle activity (10)(11)(12).”
From About Sleep's Role in Memory (2013) · cites this paper as [10]
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“The hypothesis has been challenged by findings showing that procedural tasks like visuomotor adaptation and visual texture discrimination also benefit from SWS (10,433,581,582).”
From About Sleep's Role in Memory (2013) · cites this paper as [10]
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“Correspondingly, reducing SWA during sleep by the presentation of tones was revealed to suppress the sleep-dependent improvement in visuomotor adaptation skills (691, 692) and also in texture discrimination skills (10).”
From About Sleep's Role in Memory (2013) · cites this paper as [10]
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Cites
David, F. N., & Tukey, J. W. (1977) · Biometrics · doi:10.2307/2529486 · Cited by 12,707
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Two-Process Model of Sleep Regulation
Binder, M. D., Hirokawa, N., & Windhorst, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-29678-2_6166 · Cited by 3,900
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118
Sleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Huber, R., Felice Ghilardi, M., Massimini, M., & Tononi, G. (2004) · Nature · doi:10.1038/nature02663 · Cited by 1,854
Timing of human sleep: recovery process gated by a circadian pacemaker
Daan, S., Beersma, D. G. M., & Borbély, A. A. (1984) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1984.246.2.r161 · Cited by 1,424
Sleep and synaptic homeostasis: a hypothesis
Tononi, G., & Cirelli, C. (2003) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2003.09.004 · Cited by 1,217
The role of sleep in learning and memory
Maquet, P. (2001) · Science · doi:10.1126/science.1062856 · Cited by 1,177
Sleep-Dependent Learning and Memory Consolidation
Walker, M. P., & Stickgold, R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.031 · Cited by 1,113 · cited 2×
“In developing animals, sleep can induce synaptic remodeling (Frank et al., 2001), and in humans it has been associated with memory consolidation and learning (for review, see Maquet, 2001; Walker and Stickgold, 2004).”
BackgroundEffects of early and late nocturnal sleep on declarative and procedural memory
Plihal, W., & Born, J. (1997) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1997.9.4.534 · Cited by 1,026
Sleep deprivation: effect on sleep stages and EEG power density in man
Borbély, A. A., Baumann, F., Brandeis, D., Strauch, I., & Lehmann, D. (1981) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(81)90225-x · Cited by 1,013
Dependence on REM Sleep of Overnight Improvement of a Perceptual Skill
Karni, A., Tanne, D., Rubenstein, B. S., Askenasy, J. J. M., & Sagi, D. (1994) · Science · doi:10.1126/science.8036518 · Cited by 1,002
Learning-dependent increases in sleep spindle density
Gais, S., Mölle, M., Helms, K., & Born, J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-15-06830.2002 · Cited by 859
The time course of learning a visual skill
Karni, A., & Sagi, D. (1993) · Nature · doi:10.1038/365250a0 · Cited by 792
Are spatial memories strengthened in the human hippocampus during slow wave sleep?
Peigneux, P., Laureys, S., Fuchs, S., Collette, F., Perrin, F., Reggers, J., Phillips, C., Degueldre, C., Del Fiore, G., Aerts, J., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.007 · Cited by 766
Experience-dependent changes in cerebral activation during human REM sleep
Maquet, P., Laureys, S., Peigneux, P., Fuchs, S., Petiau, C., Phillips, C., Aerts, J., Del Fiore, G., Degueldre, C., Meulemans, T., et al. (2000) · Nature Neuroscience · doi:10.1038/77744 · Cited by 747
Visual discrimination learning requires sleep after training
Stickgold, R., James, L., & Hobson, J. A. (2000) · Nature Neuroscience · doi:10.1038/81756 · Cited by 715
Extensive and divergent effects of sleep and wakefulness on brain gene expression
Cirelli, C., Gutierrez, C. M., & Tononi, G. (2004) · Neuron · doi:10.1016/s0896-6273(03)00814-6 · Cited by 627
Sleep-dependent learning: A nap is as good as a night
Mednick, S., Nakayama, K., & Stickgold, R. (2003) · Nature Neuroscience · doi:10.1038/nn1078 · Cited by 594
Visual Discrimination Task Improvement: A Multi-Step Process Occurring During Sleep
Stickgold, R., Whidbee, D., Schirmer, B., Patel, V., & Hobson, J. A. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/089892900562075 · Cited by 560
Early sleep triggers memory for early visual discrimination skills
Gais, S., Plihal, W., Wagner, U., & Born, J. (2000) · Nature Neuroscience · doi:10.1038/81881 · Cited by 558
Daytime naps, motor memory consolidation and regionally specific sleep spindles
Nishida, M., & Walker, M. P. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000341 · Cited by 531
Sleep Enhances Plasticity in the Developing Visual Cortex
Frank, M. G., Issa, N. P., & Stryker, M. P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00279-3 · Cited by 523
Sleep states and memory processes
Smith, C. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00024-n · Cited by 473
Effect of unilateral somatosensory stimulation prior to sleep on the sleep EEG in humans
KATTLER, H., DIJK, D., & BORBÉLY, A. A. (1994) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1994.tb00123.x · Cited by 401
Neural correlates of perceptual learning: A functional MRI study of visual texture discrimination
Schwartz, S., Maquet, P., & Frith, C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242414599 · Cited by 388
Functional topography of the human nonREM sleep electroencephalogram
Finelli, L. A., Borbély, A. A., & Achermann, P. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01597.x · Cited by 357
Coherent oscillations and short-term plasticity in corticothalamic networks
Steriade, M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01407-1 · Cited by 321
All‐night dynamics of the human sleep EEG
AESCHBACH, D., & BORBÉLY, A. A. (1993) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1993.tb00065.x · Cited by 299
Self-citationBlake, H., & Gerard, R. W. (1937) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1937.119.4.692 · Cited by 276
Long-term depression: a cascade of induction and expression mechanisms
Kemp, N. M., & Bashir, Z. I. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00013-2 · Cited by 247
Time course of EEG power density during long sleep in humans
Dijk, D., Brunner, D. P., & Borbély, A. A. (1990) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1990.258.3.r650 · Cited by 236
Huber, R., Esser, S. K., Ferrarelli, F., Massimini, M., Peterson, M. J., & Tononi, G. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000276 · Cited by 232
Encoding Difficulty Promotes Postlearning Changes in Sleep Spindle Activity during Napping
Schmidt, C., Peigneux, P., Muto, V., Schenkel, M., Knoblauch, V., Münch, M. Y., de Quervain, D. J. ‐., Wirz‐Justice, A., & Cajochen, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2464-06.2006 · Cited by 230
Vyazovskiy, V., Borbély, A. A., & Tobler, I. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00230.x · Cited by 203
Homeostatic sleep regulation in habitual short sleepers and long sleepers
Aeschbach, D., Cajochen, C., Landolt, H., & Borbély, A. A. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.270.1.r41 · Cited by 200
Self-citationSigma (12–15 Hz) and Delta (0.3–3 Hz) EEG oscillate reciprocally within NREM sleep
Uchida, S., Maloney, T., March, J. D., Azari, R., & Feinberg, I. (1991) · Brain Research Bulletin · doi:10.1016/0361-9230(91)90286-s · Cited by 129
The Functional Anatomy of Sleep-dependent Visual Skill Learning
Walker, M. P., Stickgold, R., Jolesz, F. A., & Yoo, S.-S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi043 · Cited by 121
Jan Dijk, D., Beersma, D. G. M., Daan, S., Bloem, G. M., & Hoofdakker, R. H. (1987) · European Archives of Psychiatry and Neurological Sciences · doi:10.1007/bf00377420 · Cited by 120
Unihemispheric enhancement of delta power in human frontal sleep EEG by prolonged wakefulness
Achermann, P., Finelli, L. A., & Borbély, A. A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02796-2 · Cited by 102
Ferrara, M. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.7.737 · Cited by 81
Recovery within day-time sleep after slow wave sleep suppression
Gillberg, M., Anderzén, I., & Åkerstedt, T. (1991) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(91)90180-c · Cited by 28
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Diekelmann, S., & Born, J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2762 · Cited by 3,760
Rasch, B., & Born, J. (2013) · Physiological Reviews · doi:10.1152/physrev.00032.2012 · Cited by 2,783
“The hypothesis has been challenged by findings showing that procedural tasks like visuomotor adaptation and visual texture discrimination also benefit from SWS (10, 433, 581, 582).”
BackgroundTononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356
Regional Slow Waves and Spindles in Human Sleep
Nir, Y., Staba, R. J., Andrillon, T., Vyazovskiy, V. V., Cirelli, C., Fried, I., & Tononi, G. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.043 · Cited by 924
The whats and whens of sleep-dependent memory consolidation
Diekelmann, S., Wilhelm, I., & Born, J. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2008.08.002 · Cited by 566
Metadata
- Authors
- Aeschbach, D., Cutler, A. J., & Ronda, J. M.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-03-12
- Volume
- 28
- Issue
- 11
- Pages
- 2766-2772
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6670683
- OpenAlex
- W1967290403
- Cited by
- 142
- References
- 44
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 2 · 2022: 11 · 2021: 6 · 2020: 6 · 2019: 10 · 2018: 9 · 2017: 9 · 2016: 4 · 2015: 5 · 2014: 15 · 2013: 12 · 2012: 8
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Brigham and Women's Hospital (M01 RR02635)
- Harvard University
- Deutsches Krebsforschungszentrum
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (NCRR-GCRC-M01-RR02635, RR‐02635)
- National Center for Research Resources (GCRC-M01-RR02635, M01RR002635)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- slow-wave activity, sleep homeostasis, perceptual learning, texture discrimination, NREM sleep, sleep-dependent learning, visual learning, EEG spectral power, neuroplasticity
- MeSH terms
- Adolescent, Adult, Electroencephalography, Female, Homeostasis, Humans, Learning, Male, Photic Stimulation, Sleep, Sleep Stages, Sleep, REM, Visual Perception, Single-Blind Method
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