Cited by 145Hormonal and reproductive studiesObstructive Sleep Apnea ResearchMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 81 of the 82 references it cites were found in a registry or an index.

Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial

Hoyos, Camilla M, Yee, Brendon J, Phillips, Craig L, Machan, Elizabeth A, Grunstein, Ronald R, Liu, Peter Y·2012·European Journal of Endocrinology

DOI 10.1530/eje-12-0525

Open this paper in CoChat — free account

Abstract

BACKGROUND: The combination of male gender, obstructive sleep apnoea (OSA) and obesity magnifies cardiometabolic risk. There has been no systematic study evaluating whether testosterone therapy can improve cardiometabolic health in obese men with OSA by improving body composition, visceral abdominal fat and insulin sensitivity. OBJECTIVE: To assess body compositional and cardiometabolic effects of testosterone treatment in obese men with severe OSA. DESIGN: An 18-week randomised, double-blind, placebo-controlled and parallel group trial in 67 men. METHODS: Participants (age=49 ± 12 years, apnoea hypopnoea index=39.9 ± 17.7 events/h, BMI=31.3 ± 5.2 kg/m(2)) were placed on a hypocaloric diet and received i.m. injections of either 1000 mg testosterone undecanoate (n=33) or placebo (n=34) for 18 weeks. Outcomes were the changes in body composition (total muscle mass, total and abdominal fat, total body dual-energy X-ray absorptiometry and computerised tomography (CT)), weight, insulin sensitivity (homeostasis model assessment), abdominal liver fat (CT), arterial stiffness (pulse wave analysis), resting metabolic rate and respiratory quotient (indirect calorimetry) and blood lipids and metabolic syndrome from baseline to week 18. RESULTS: After 18 weeks, testosterone treatment increased insulin sensitivity (-1.14 units, 95% confidence interval (95% CI) -2.27 to -0.01, P<0.05), reduced liver fat (0.09 Hounsfield attenuation ratio, 95% CI 0.009 to 0.17, P=0.03) and increased muscle mass (1.6 kg, 95% CI 0.69 to 2.5, P=0.0009) to a greater extent than placebo. Other measures of body composition and regional adiposity as well as the number of participants with metabolic syndrome did not change. Testosterone also decreased arterial stiffness (augmentation index) by 3.2% (95% CI -6.01 to -0.46%, P=0.02) and decreased the respiratory quotient (95% CI -0.04, -0.08 to -0.001, P=0.04) after 18 weeks compared with placebo. CONCLUSION: Eighteen weeks of testosterone therapy in obese men with OSA improved several important cardiometabolic parameters but did not differentially reduce overall weight or the metabolic syndrome. Longer term studies are required.

Integrity signals

Registry

Crossref · 10.1530/eje-12-0525

Cites

81 of 81 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860
Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.
(2002) · Circulation · doi:10.1161/circ.106.25.3143 · Cited by 14,092
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077
Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study
Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71141-7 · Cited by 4,678
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
The American Urological Association Symptom Index for Benign Prostatic Hyperplasia
Barry, M. J., Fowler, F. J., O’Leary, M. P., Bruskewitz, R. C., Holtgrewe, H. L., Mebust, W. K., & Cockett, A. T. �. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)36966-5 · Cited by 3,455

Show all 82 references

Research works printed but not linked: 7

1995, INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS, 19, 410
2008, 31, 1079
2008, 31, 1071
1992, INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS, 16, 991
1995, INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS, 19, 614
2007, 191, 235
Jockenh vel, 1997, European journal of medical research, 2, 293

Sorted by citations

Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials
Xu, L., Freeman, G., Cowling, B. J., & Schooling, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-108 · Cited by 569
Testosterone and obesity
Kelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487
Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis
Corona, G., Rastrelli, G., Monami, M., Saad, F., Luconi, M., Lucchese, M., Facchiano, E., Sforza, A., Forti, G., Mannucci, E., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0955 · Cited by 414
Cardiovascular risk associated with testosterone-boosting medications: a systematic review and meta-analysis
Corona, G., Maseroli, E., Rastrelli, G., Isidori, A. M., Sforza, A., Mannucci, E., & Maggi, M. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.950653 · Cited by 297
Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
Rao, P. M., Kelly, D. M., & Jones, T. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.122 · Cited by 292
Endocrine aspects of metabolic dysfunction-associated steatotic liver disease (MASLD): Beyond insulin resistance
Hutchison, A. L., Tavaglione, F., Romeo, S., & Charlton, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.08.030 · Cited by 250
THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study
Corona, G., Giagulli, V. A., Maseroli, E., Vignozzi, L., Aversa, A., Zitzmann, M., Saad, F., Mannucci, E., & Maggi, M. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-0262 · Cited by 217
Testosterone Therapy and Cardiovascular Risk: Advances and Controversies
Morgentaler, A., Miner, M. M., Caliber, M., Guay, A. T., Khera, M., & Traish, A. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.10.011 · Cited by 213
Long‐term testosterone therapy in hypogonadal men ameliorates elements of the metabolic syndrome: an observational, long‐term registry study
Traish, A. M., Haider, A., Doros, G. D., & Saad, F. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12319 · Cited by 188
Diagnosis and treatment of late-onset hypogonadism: Systematic review and meta-analysis of TRT outcomes
Corona, G., Rastrelli, G., & Maggi, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.002 · Cited by 177
European Association of Urology Guidelines on Male Sexual and Reproductive Health: 2025 Update on Male Hypogonadism, Erectile Dysfunction, Premature Ejaculation, and Peyronie's Disease.
Salonia, A., Capogrosso, P., Boeri, L., Cocci, A., Corona, G., Dinkelman-Smit, M., Falcone, M., Jensen, C. F., Gül, M., Kalkanli, A., et al. (2025) · European Urology · doi:10.1016/j.eururo.2025.04.010 · Cited by 174
Risks and benefits of testosterone therapy in older men
Spitzer, M., Huang, G., Basaria, S., Travison, T. G., & Bhasin, S. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.73 · Cited by 154
Obesity and late-onset hypogonadism
Corona, G., Vignozzi, L., Sforza, A., Mannucci, E., & Maggi, M. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.06.031 · Cited by 154
Male Obesity-related Secondary Hypogonadism – Pathophysiology, Clinical Implications and Management
Fernandez, C. J., Department of Endocrinology & Metabolism, P. H., Chacko, E. C., Department of Endocrinology, J. G. H., Pappachan, J. M., & Department of Endocrinology & Metabolism, L. T. H. N. F. T. (2019) · European Endocrinology · doi:10.17925/ee.2019.15.2.83 · Cited by 145
Reproductive Endocrinology of Nonalcoholic Fatty Liver Disease
Grossmann, M., Wierman, M. E., Angus, P., & Handelsman, D. J. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00158 · Cited by 146
Testosterone and Cardiovascular Risk: Meta-Analysis of Interventional Studies
Corona, G., Rastrelli, G., Di Pasquale, G., Sforza, A., Mannucci, E., & Maggi, M. (2018) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2018.04.641 · Cited by 138
Endocrine Society of Australia position statement on male hypogonadism (part 1): assessment and indications for testosterone therapy
Yeap, B. B., Grossmann, M., McLachlan, R. I., Handelsman, D. J., Wittert, G. A., Conway, A. J., Stuckey, B. G., Lording, D. W., Allan, C. A., Zajac, J. D., et al. (2016) · Medical Journal of Australia · doi:10.5694/mja16.00393 · Cited by 135
Long-Term Testosterone Therapy Improves Cardiometabolic Function and Reduces Risk of Cardiovascular Disease in Men with Hypogonadism: A Real-Life Observational Registry Study Setting Comparing Treated and Untreated (Control) Groups
Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2017) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417691136 · Cited by 130
Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis
Jaruvongvanich, V., Sanguankeo, A., Riangwiwat, T., & Upala, S. (2017) · Annals of Hepatology · doi:10.5604/01.3001.0009.8593 · Cited by 170
Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis
Borst, S. E., Shuster, J. J., Zou, B., Ye, F., Jia, H., Wokhlu, A., & Yarrow, J. F. (2014) · BMC Medicine · doi:10.1186/s12916-014-0211-5 · Cited by 128
Meta-analyses of the Association of Sleep Apnea with Insulin Resistance, and the Effects of CPAP on HOMA-IR, Adiponectin, and Visceral Adipose Fat
Iftikhar, I. H., Hoyos, C. M., Phillips, C. L., & Magalang, U. J. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.4610 · Cited by 126
Self-citation
Cardiovascular Risks of Exogenous Testosterone Use Among Men: A Systematic Review and Meta-Analysis
Alexander, G. C., Iyer, G. S., Lucas, E. J., Lin, D. H., & Singh, S. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.09.017 · Cited by 120
The impact of testosterone replacement therapy on glycemic control, vascular function, and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes
Groti, K., Žuran, I., Antonič, B., Foršnarič, L., & Pfeifer, M. (2018) · The Aging Male · doi:10.1080/13685538.2018.1468429 · Cited by 117
Testosterone, Sex Hormone-Binding Globulin and Nonalcoholic Fatty Liver Disease: a Systematic Review and Meta-Analysis.
(2017) · PubMed · doi:10.5604/16652681.1235481 · Cited by 111
Metabolic and hormonal effects of ‘catch‐up’ sleep in men with chronic, repetitive, lifestyle‐driven sleep restriction
Killick, R., Hoyos, C. M., Melehan, K. L., Dungan, G. C., Poh, J., & Liu, P. Y. (2015) · Clinical Endocrinology · doi:10.1111/cen.12747 · Cited by 108
Self-citation
Association between exogenous testosterone and cardiovascular events: an overview of systematic reviews
Onasanya, O., Iyer, G. S., Lucas, E. J., Lin, D. H., Singh, S., & Alexander, G. C. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30215-7 · Cited by 104
Effects of Long-Term Testosterone Therapy on Patients with “Diabesity”: Results of Observational Studies of Pooled Analyses in Obese Hypogonadal Men with Type 2 Diabetes
Haider, A., Yassin, A. A., Doros, G. D., & Saad, F. (2014) · International Journal of Endocrinology · doi:10.1155/2014/683515 · Cited by 101
Effects of liraglutide on obesity-associated functional hypogonadism in men
Jensterle, M., Podbregar, A., Goricar, K., Gregoric, N., & Janez, A. (2019) · Endocrine Connections · doi:10.1530/ec-18-0514 · Cited by 101
Risks and Benefits of Late Onset Hypogonadism Treatment: An Expert Opinion
Corona, G., Vignozzi, L., Sforza, A., & Maggi, M. (2013) · The World Journal of Men s Health · doi:10.5534/wjmh.2013.31.2.103 · Cited by 101
Testosterone and glucose metabolism in men: current concepts and controversies
Grossmann, M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0393 · Cited by 104
Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice
Kelly, D. M., Nettleship, J. E., Akhtar, S., Muraleedharan, V., Sellers, D. J., Brooke, J. C., McLaren, D. S., Channer, K. S., & Jones, T. H. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.06.007 · Cited by 98
Mechanisms in endocrinology: Non-alcoholic fatty liver disease in common endocrine disorders
Hazlehurst, J., & Tomlinson, J. (2013) · European Journal of Endocrinology · doi:10.1530/eje-13-0296 · Cited by 99
Sex differences in vascular aging in response to testosterone
Moreau, K. L., Babcock, M. C., & Hildreth, K. L. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00294-8 · Cited by 98
Testosterone and weight loss
Traish, A. M. (2014) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000086 · Cited by 95
Endocrine causes of nonalcoholic fatty liver disease
Marino, L. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i39.11053 · Cited by 93
Adverse effects of testosterone replacement therapy: an update on the evidence and controversy
Grech, A., Breck, J., & Heidelbaugh, J. (2014) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098614548680 · Cited by 81
Testosterone Replacement Ameliorates Nonalcoholic Fatty Liver Disease in Castrated Male Rats
Nikolaenko, L., Jia, Y., Wang, C., Diaz‐Arjonilla, M., Yee, J. K., French, S. W., Liu, P. Y., Laurel, S., Chong, C., Lee, K., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1648 · Cited by 87
Self-citation
Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans
Tchernof, A., Brochu, D., Maltais‐Payette, I., Mansour, M. F., Marchand, G. B., Carreau, A., & Kapeluto, J. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170009 · Cited by 113
Sleep, testosterone and cortisol balance, and ageing men
Liu, P. Y., & Reddy, R. T. (2022) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-022-09755-4 · Cited by 80
“Vol.:(0123456789) Keywords Androgen · Glucocorticoid · Cardiometabolic health · Circadian · Sleep disordered breathing Abbreviations CPAP Continuous positive airway pressure GnRH Gonadotropin-releasing hormone LH Luteinizing hormone NREM Non-rapid eye movement OSA Obstructive sleep apnea REM Rapid eye movement SD Stan…”
BackgroundInfluentialSelf-citation
Nonalcoholic steatohepatitis as a novel player in metabolic syndrome-induced erectile dysfunction: An experimental study in the rabbit
Vignozzi, L., Filippi, S., Comeglio, P., Cellai, I., Sarchielli, E., Morelli, A., Rastrelli, G., Maneschi, E., Galli, A., Vannelli, G. B., et al. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.014 · Cited by 81
Injectable testosterone undecanoate for the treatment of hypogonadism
Corona, G., Maseroli, E., & Maggi, M. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.944896 · Cited by 79
Muscular responses to testosterone replacement vary by administration route: a systematic review and meta‐analysis
Skinner, J. W., Otzel, D. M., Bowser, A., Nargi, D., Agarwal, S., Peterson, M. D., Zou, B., Borst, S. E., & Yarrow, J. F. (2018) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12291 · Cited by 76
Pathophysiology of NASH in endocrine diseases
Gariani, K., & Jornayvaz, F. R. (2021) · Endocrine Connections · doi:10.1530/ec-20-0490 · Cited by 77
Low testosterone and non-alcoholic fatty liver disease: Evidence for their independent association in men with chronic spinal cord injury
Barbonetti, A., Caterina Vassallo, M. R., Cotugno, M., Felzani, G., Francavilla, S., & Francavilla, F. (2016) · The Journal of Spinal Cord Medicine · doi:10.1179/2045772314y.0000000288 · Cited by 75
Randomized controlled trials – mechanistic studies of testosterone and the cardiovascular system
Jones, T. H., & Kelly, D. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_6_18 · Cited by 76
Hypogonadism as a possible link between metabolic diseases and erectile dysfunction in aging men
Corona, G., Bianchini, S., Sforza, A., Vignozzi, L., & Maggi, M. (2015) · HORMONES · doi:10.14310/horm.2002.1635 · Cited by 70
Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife
Sarkar, M. A., Wellons, M., Cedars, M. I., VanWagner, L. B., Gunderson, E. P., Ajmera, V. H., Torchen, L. C., Siscovick, D. S., Carr, J. J., Terry, J. G., et al. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.44 · Cited by 68
Low serum sex hormone‐binding globulin is associated with nonalcoholic fatty liver disease in type 2 diabetic patients
Hua, X., Sun, Y., Zhong, Y., Feng, W., Huang, H., Wang, W., Zhang, T., & Hu, Y. (2013) · Clinical Endocrinology · doi:10.1111/cen.12360 · Cited by 65
Testosterone and metabolic syndrome
Cunningham, G. R. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.148068 · Cited by 65
Critical Update of the 2010 Endocrine Society Clinical Practice Guidelines for Male Hypogonadism
Seftel, A. D., Kathrins, M. N., & Niederberger, C. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.06.002 · Cited by 63
Testosterone a key factor in gender related metabolic syndrome
Bianchi, V. E., & Locatelli, V. (2018) · Obesity Reviews · doi:10.1111/obr.12633 · Cited by 65
Association Between Severity of Obstructive Sleep Apnea and Blood Markers of Liver Injury
Trzépizur, W., Boursier, J., Mansour, Y., Vaillant, M. L., Chollet, S., Pigeanne, T., Bizieux‐Thaminy, A., Humeau, M. P., Alizon, C., Goupil, F., et al. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2016.04.037 · Cited by 64
Low testosterone in men predicts impaired arterial elasticity and microvascular function
Corrigan, F. E., Mheid, I. A., Eapen, D. J., Hayek, S. S., Sher, S., Martin, G. S., & Quyyumi, A. A. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.065 · Cited by 57
A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research
Liu, P. Y. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00683 · Cited by 55
Self-citation
Obesity and Hypogonadism
Lamm, S. H., Chidakel, A. R., & Bansal, R. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.005 · Cited by 51
Testosterone and the Heart
Kirby, M., Hackett, G. I., & Ramachandran, S. (2019) · European Cardiology Review · doi:10.15420/ecr.2019.13.1 · Cited by 53
5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes
Nasiri, M., Nikolaou, N., Parajes, S., Krone, N. P., Valsamakis, G., Mastorakos, G., Hughes, B., Taylor, A., Bujalska, I. J., Gathercole, L. L., et al. (2015) · Endocrinology · doi:10.1210/en.2015-1149 · Cited by 50
Differential effects of 11 years of long-term injectable testosterone undecanoate therapy on anthropometric and metabolic parameters in hypogonadal men with normal weight, overweight and obesity in comparison with untreated controls: real-world data from a controlled registry study
Saad, F., Doros, G. D., Haider, K. S., & Haider, A. (2020) · International Journal of Obesity · doi:10.1038/s41366-019-0517-7 · Cited by 49
Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men
Maseroli, E., Comeglio, P., Corno, C., Cellai, I., Filippi, S., Mello, T., Galli, A., Rapizzi, E., Presenti, L., Truglia, M., et al. (2020) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01381-8 · Cited by 49
Liver Disease in Men Undergoing Androgen Deprivation Therapy for Prostate Cancer
Gild, P., Cole, A. P., Krasnova, A., Dickerman, B. A., von Landenberg, N., Sun, M., Mucci, L. A., Lipsitz, S. R., Chun, F. K. ‐., Nguyen, P. L., et al. (2018) · The Journal of Urology · doi:10.1016/j.juro.2018.03.135 · Cited by 46
Testosterone protects high-fat/low-carbohydrate diet-induced nonalcoholic fatty liver disease in castrated male rats mainly via modulating endoplasmic reticulum stress
Jia, Y., Yee, J. K., Wang, C., Nikolaenko, L., Diaz‐Arjonilla, M., Cohen, J. N., French, S. W., Liu, P. Y., Lue, Y., Lee, W. P., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00124.2017 · Cited by 45
Self-citation
Secondary male hypogonadism: A prevalent but overlooked comorbidity of obesity
Fernandez-Garcia, J.-C., Molina‐Vega, M., Muñoz-Garach, A., Damas-Fuentes, M., & Tinahones, F. J. (2018) · Asian Journal of Andrology · doi:10.4103/aja.aja_44_18 · Cited by 49
Treatment of nonalcoholic fatty liver disease: Where do we stand? an overview
Dajani, A. I., & Abu-Hammour, A. (2016) · Saudi Journal of Gastroenterology · doi:10.4103/1319-3767.178527 · Cited by 41
Metabolic Effects of Testosterone Therapy in Men with Type 2 Diabetes and Metabolic Syndrome
Hackett, G. I. (2019) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2018.12.004 · Cited by 39
Elderly men over 65 years of age with late-onset hypogonadism benefit as much from testosterone treatment as do younger men
Saad, F., Yassin, A. A., Haider, A., Doros, G. D., & Gooren, L. J. (2015) · Korean journal of urology · doi:10.4111/kju.2015.56.4.310 · Cited by 36
Obesity and age as dominant correlates of low testosterone in men irrespective of diabetes status
Fui, M. N. T., Hoermann, R., Cheung, A. S., Gianatti, E., Zajac, J. D., & Grossmann, M. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00124.x · Cited by 33
Testosterone and estradiol are not affected in male and female patients with obstructive sleep apnea treated with continuous positive airway pressure
Celec, P., Mucska, I., Ostatníková, D., & Hodosy, J. (2014) · Journal of Endocrinological Investigation · doi:10.1007/s40618-013-0003-3 · Cited by 33
Long-term testosterone therapy improves liver parameters and steatosis in hypogonadal men: a prospective controlled registry study
Yassin, A. A., Alwani, M. M., Alzubaidi, R. T., Almehmadi, Y., Nettleship, J. E., Al‐Rumaihi, K., Albaba, B., Kelly, D. M., & Saad, F. (2020) · The Aging Male · doi:10.1080/13685538.2020.1867094 · Cited by 31
Impact of Testosterone Deficiency and Testosterone Therapy on Lower Urinary Tract Symptoms in Men with Metabolic Syndrome
Traish, A. M., & Johansen, V. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180032 · Cited by 32
MR spectroscopy of hepatic fat and adiponectin and leptin levels during testosterone therapy in type 2 diabetes: a randomized, double-blinded, placebo-controlled trial
Magnussen, L. V., Andersen, P. E., Diaz, A., Ostojic, J. N., Højlund, K., HOUGAARD, D. M., Christensen, A. N., Nielsen, T. L., & Andersen, M. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0071 · Cited by 29
Clamping Cortisol and Testosterone Mitigates the Development of Insulin Resistance during Sleep Restriction in Men
Liu, P. Y., Lawrence-Sidebottom, D., Piotrowska, K., Zhang, W., Iranmanesh, A., Auchus, R. J., Veldhuis, J. D., & Van Dongen, H. P. A. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab375 · Cited by 28
Self-citation
Hypogonadal men with psoriasis benefit from long-term testosterone replacement therapy - a series of 15 case reports
Saad, F., Haider, A., & Gooren, L. J. (2015) · Andrologia · doi:10.1111/and.12452 · Cited by 27
Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans
Tchernof, A., Brochu, D., Maltais‐Payette, I., Mansour, M. F., Marchand, G. B., Carreau, A., & Kapeluto, J. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00043.x · Cited by 27
Outcomes of testosterone therapy in men with testosterone deficiency (TD): Part II
Traish, A. M. (2014) · Steroids · doi:10.1016/j.steroids.2014.05.004 · Cited by 27
Testosterone deficiency and cardiovascular mortality
Morgentaler, A. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.143248 · Cited by 28
Hepatic actions of androgens in the regulation of metabolism
Birzniece, V. (2018) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000405 · Cited by 28
Possible mechanisms underlying fatty liver in a rat model of male hypogonadism: A protective role for testosterone
Sakr, H. F., Hussein, A. M., Eid, E. A., & Alkhateeb, M. A. (2018) · Steroids · doi:10.1016/j.steroids.2018.04.004 · Cited by 28
Increased sexual desire with exogenous testosterone administration in men with obstructive sleep apnea: a randomized placebo-controlled study
Melehan, K. L., Hoyos, C. M., Yee, B. J., Wong, K. K., Buchanan, P. R., Grunstein, R. R., & Liu, P. Y. (2016) · Andrology · doi:10.1111/andr.12132 · Cited by 26
Self-citation
Testosterone treatment improves liver function and reduces cardiovascular risk: A long-term prospective study
Al-Qudimat, A. R., Al‐Zoubi, R. M., Yassin, A. A., Alwani, M. M., Aboumarzouk, O. M., Al‐Rumaihi, K., Talib, R. A., & Ansari, A. A. (2021) · Arab Journal of Urology · doi:10.1080/2090598x.2021.1959261 · Cited by 25
Cardiovascular safety of testosterone replacement therapy in men: an updated systematic review and meta-analysis
Corona, G., Rastrelli, G., Sparano, C., Carinci, V., Casella, G., Vignozzi, L., Sforza, A., & Maggi, M. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2337741 · Cited by 26
Association between metabolic syndrome, hepatic steatosis, and testosterone deficiency: evidences from studies with men and rodents
Hermoso, D. A. M., Bizerra, P. F. V., Constantin, R. P., Ishii‐Iwamoto, E. L., & Gilglioni, E. H. (2020) · The Aging Male · doi:10.1080/13685538.2020.1764927 · Cited by 24
MANAGEMENT OF ENDOCRINE DISEASE: Rationale and current evidence for testosterone therapy in the management of obesity and its complications
Lapauw, B., & Kaufman, J. (2020) · European Journal of Endocrinology · doi:10.1530/eje-20-0394 · Cited by 24
Cardiovascular Disease, Hypogonadism and Erectile Dysfunction: Early Detection, Prevention and the Positive Effects of Long-Term Testosterone Treatment: Prospective Observational, Real-Life Data
Alwani, M. M., Yassin, A. A., Talib, R. A., Al-Qudimat, A. R., Aboumarzouk, O. M., Al‐Zoubi, R. M., Saad, F., Haider, K. S., & Ansari, A. A. (2021) · Vascular Health and Risk Management · doi:10.2147/vhrm.s309714 · Cited by 25
Testosterone therapy reduces hepatic steatosis in men with type 2 diabetes and low serum testosterone concentrations
Apostolov, R., Gianatti, E., Wong, D. J., Kutaiba, N., Gow, P. J., Grossmann, M., & Sinclair, M. J. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i4.754 · Cited by 24
Association of sex hormones and sex hormone-binding globulin with liver fat in men and women: an observational and Mendelian randomization study
Cai, X., Thorand, B., Hohenester, S. D., Prehn, C. P., Cecil, A., Adamski, J., Zeller, T., Dennis, A., Banerjee, R., Peters, A., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1223162 · Cited by 24
Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development
(2017) · EndocrinologyJN · doi:10.1210/en.2016-1668 · Cited by 71
Advances in the treatment of functional male hypogonadism
Corona, G., Rastrelli, G., Sparano, C., Vignozzi, L., Sforza, A., & Maggi, M. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2296022 · Cited by 19
Hypogonadism and nonalcoholic fatty liver disease
Papadimitriou, K., Mousiolis, A. C., Mintziori, G., Tarenidou, C., Pοlyzos, S. A., & Goulis, D. G. (2024) · Endocrine · doi:10.1007/s12020-024-03878-1 · Cited by 18
Effect of CPAP therapy on liver disease in patients with OSA: a review
Liu, X., Miao, Y., Wu, F., Du, T., & Zhang, Q. (2018) · Sleep And Breathing · doi:10.1007/s11325-018-1622-x · Cited by 16
High-dose testosterone supplementation disturbs liver pro-oxidant/antioxidant balance and function in adolescent male Wistar rats undergoing moderate-intensity endurance training
Sadowska‐Krępa, E., Kłapcińska, B., Nowara, A., Jagsz, S., Szołtysek-Bołdys, I., Chalimoniuk, M., Langfort, J., & Chrapusta, S. J. (2020) · PeerJ · doi:10.7717/peerj.10228 · Cited by 19
[METHODS OF EVALUATION OF MUSCLE MASS: A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS].
Moreira, O. C., de Oliveira, C. E. P., Luján, R. C., Romero-Pérez, E. M., & Fernández, J. A. D. P. (2015) · PubMed · doi:10.3305/nh.2015.32.3.9322 · Cited by 19
Cardiovascular impact of testosterone therapy for hypogonadism
Rastrelli, G., Dicuio, M., Reismann, Y., Sforza, A., Maggi, M., & Corona, G. (2018) · Expert Review of Cardiovascular Therapy · doi:10.1080/14779072.2018.1510314 · Cited by 14
High-dose testosterone enanthate supplementation boosts oxidative stress, but exerts little effect on the antioxidant barrier in sedentary adolescent male rat liver
Sadowska‐Krępa, E., Kłapcińska, B., Jagsz, S., Nowara, A., Szołtysek-Bołdys, I., Chalimoniuk, M., Langfort, J., & Chrapusta, S. J. (2017) · Pharmacological Reports · doi:10.1016/j.pharep.2017.02.023 · Cited by 14
Cross-sectional and longitudinal associations between serum testosterone concentrations and hypertension: Results from the Fangchenggang Area Male Health and Examination Survey in China
Jiang, Y., Ye, J., Zhao, M., Tan, A., Zhang, H., Gao, Y., Lu, Z., Wu, C., Hu, Y., Wang, Q., et al. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.08.027 · Cited by 14
Metabolic Effects of Testosterone Added to Intensive Lifestyle Intervention in Older Men With Obesity and Hypogonadism
González-Gil, A. M., Barnouin, Y., Celli, A., Viola, V., Villarreal, M. D., Nava, M. L. D., Sciuk, A., Qualls, C., Armamento‐Villareal, R., & Villareal, D. T. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae249 · Cited by 14
The clinical importance of quantifying body fat distribution during androgen deprivation therapy for prostate cancer
Foulkes, S., Daly, R. M., & Fraser, S. F. (2017) · Endocrine Related Cancer · doi:10.1530/erc-16-0505 · Cited by 13
Relationship between total testosterone, sex hormone–binding globulin levels and the severity of non-alcoholic fatty liver disease in males: a meta-analysis
Mo, M.-Q., Huang, Z., Yang, Z., Liao, Y., Xia, N., & Pan, L. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221106879 · Cited by 13
Short-term effects of continuous positive airway pressure on sex hormones in men and women with sleep apnoea syndrome
Vlková, B., Mucska, I., Hodosy, J., & Celec, P. (2013) · Andrologia · doi:10.1111/and.12092 · Cited by 12
Effectiveness of testosterone therapy in obese men with low testosterone levels, for losing weight, controlling obesity complications, and preventing cardiovascular events
Mangolim, A. S., Brito, L. D. A. R., & Nogueira, V. D. S. N. (2018) · Medicine · doi:10.1097/md.0000000000010482 · Cited by 12
Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China
Sun, K., Wang, C., Lao, G., Lin, D., Huang, C., Li, N., Li, L., Li, F., Xiao, H., & Yan, L. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-033991 · Cited by 12

Authors: Hoyos, C. M., Yee, B. J., Phillips, C. L., Machan, E. A., Grunstein, R. R., & Liu, P. Y.
Affiliations: The University of Sydney (AU)
Corresponding author: Liu, Peter Y
ORCID: Hoyos, Camilla M
Yee, Brendon J
Phillips, Craig L
Grunstein, Ronald R
Liu, Peter Y
Venue: European Journal of Endocrinology
Publisher: Oxford University Press (OUP)
Published: 2012-10
Volume: 167
Issue: 4
Pages: 531-541
ISSN: 0804-4643 (ISSN-L)
1479-683X
DOI: 10.1530/eje-12-0525
OpenAlex: W2143044197
Cited by: 145
References: 82
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 7 · 2018: 20 · 2017: 19 · 2016: 9 · 2015: 21 · 2014: 13 · 2013: 14
FWCI: 12.30
Type: journal article
Language: en
Open access: closed
Locations: European Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Centre National de la Recherche Scientifique
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: testosterone replacement therapy, testosterone undecanoate, obstructive sleep apnea, obesity, body composition, insulin sensitivity, visceral fat, liver fat, muscle mass, arterial stiffness, metabolic syndrome, cardiometabolic risk, hypocaloric diet, respiratory quotient, resting metabolic rate, serum lipids, menopause, hormone replacement therapy
MeSH terms: Body Composition, Double-Blind Method, Heart, Hormones, Humans, Male, Metabolism, Middle Aged, Obesity, Placebos, Prostate, Severity of Illness Index, Testosterone, Treatment Outcome, Sleep Apnea, Obstructive

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks