The DOI matches its Crossref record; 81 of the 82 references it cites were found in a registry or an index.
Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a randomised placebo-controlled trial
Abstract
BACKGROUND: The combination of male gender, obstructive sleep apnoea (OSA) and obesity magnifies cardiometabolic risk. There has been no systematic study evaluating whether testosterone therapy can improve cardiometabolic health in obese men with OSA by improving body composition, visceral abdominal fat and insulin sensitivity. OBJECTIVE: To assess body compositional and cardiometabolic effects of testosterone treatment in obese men with severe OSA. DESIGN: An 18-week randomised, double-blind, placebo-controlled and parallel group trial in 67 men. METHODS: Participants (age=49 ± 12 years, apnoea hypopnoea index=39.9 ± 17.7 events/h, BMI=31.3 ± 5.2 kg/m(2)) were placed on a hypocaloric diet and received i.m. injections of either 1000 mg testosterone undecanoate (n=33) or placebo (n=34) for 18 weeks. Outcomes were the changes in body composition (total muscle mass, total and abdominal fat, total body dual-energy X-ray absorptiometry and computerised tomography (CT)), weight, insulin sensitivity (homeostasis model assessment), abdominal liver fat (CT), arterial stiffness (pulse wave analysis), resting metabolic rate and respiratory quotient (indirect calorimetry) and blood lipids and metabolic syndrome from baseline to week 18. RESULTS: After 18 weeks, testosterone treatment increased insulin sensitivity (-1.14 units, 95% confidence interval (95% CI) -2.27 to -0.01, P<0.05), reduced liver fat (0.09 Hounsfield attenuation ratio, 95% CI 0.009 to 0.17, P=0.03) and increased muscle mass (1.6 kg, 95% CI 0.69 to 2.5, P=0.0009) to a greater extent than placebo. Other measures of body composition and regional adiposity as well as the number of participants with metabolic syndrome did not change. Testosterone also decreased arterial stiffness (augmentation index) by 3.2% (95% CI -6.01 to -0.46%, P=0.02) and decreased the respiratory quotient (95% CI -0.04, -0.08 to -0.001, P=0.04) after 18 weeks compared with placebo. CONCLUSION: Eighteen weeks of testosterone therapy in obese men with OSA improved several important cardiometabolic parameters but did not differentially reduce overall weight or the metabolic syndrome. Longer term studies are required.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, an 18-week, placebocontrolled RCT in obese patients with obstructive sleep apnea demonstrated that the combination of TRT and lifestyle modifications improved insulin sensitivity, reduced liver fat, and increased muscle mass in comparison with placebo and lifestyle modifications alone (69).”
From Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis (2013) · cites this paper as [69]
In the citing paper
“substantial evidence implicate testosterone and cortisol in the development of insulin resistance.”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [87]
In the citing paper
“Randomized controlled trials show that testosterone treatment improves insulin sensitivity in men at risk for type 2 diabetes mellitus (T2DM) [86, 87]”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [87]
In the citing paper
“reduced liver fat”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [87]
In the citing paper
“improved insulin sensitivity”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [87]
In the citing paper
“18 weeks of testosterone therapy in men with OSA increased muscle mass”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [87]
In the citing paper
“heightened sexual desire compared with placebo therapy [87, 133].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [87]
In the citing paper
“Only few studies to date reported that combination of TRT and LSM is superior to LSM alone in increasing insulin sensitivity, glycemic control, muscle mass and reducing liver fat (4, 5).”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [5]
In the citing paper
“A compelling number of clinical studies demonstrated that TRT led to improvement in glycemic control and insulin sensitivity (4, 5, 37, 42), whereas some failed to confirm these observations (43).”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [5]
Citations
Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860
Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)
Grundy, S. M., Becker, D. M., Clark, L. T., Cooper, R., Denke, M. A., Howard, J. L., Hunninghake, D. B., Illingworth, D. R., Luepker, R. V., McBride, P. E., et al. (2002) · Civil War Book Review · Cited by 12,198
Prevalence and Trends in Obesity Among US Adults, 1999-2008
Flegal, K. M. (2010) · JAMA · doi:10.1001/jama.2009.2014 · Cited by 7,580
Expert consensus document on arterial stiffness: methodological issues and clinical applications
Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077
Marin, J. M., Carrizo, S. J., Vicente, E., & Agusti, A. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)71141-7 · Cited by 4,678
A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
The American Urological Association Symptom Index for Benign Prostatic Hyperplasia
Barry, M. J., Fowler, F. J., O’Leary, M. P., Bruskewitz, R. C., Holtgrewe, H. L., Mebust, W. K., & Cockett, A. T. �. (1992) · The Journal of Urology · doi:10.1016/s0022-5347(17)36966-5 · Cited by 3,455
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954
The American Urological Association Symptom Index for Benign Prostatic Hyperplasia
Barry, M. J., Fowler, F. J., O’Leary, M. P., Bruskewitz, R. C., Holtgrewe, H. L., Mebust, W. K., & Cockett, A. T. �. (2016) · The Journal of Urology · doi:10.1016/j.juro.2016.10.071 · Cited by 1,931
Sleep Disordered Breathing and Mortality: Eighteen-Year Follow-up of the Wisconsin Sleep Cohort
(2008) · Sleep · doi:10.5665/sleep/31.8.1071 · Cited by 1,853
Identification of late-onset hypogonadism in middle-aged and elderly men
Wu, F. C. W., Tajar, A., Beynon, J. M., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F. F., Forti, G., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0911101 · Cited by 1,544
Adverse Events Associated with Testosterone Administration
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000485 · Cited by 1,494
Sleep Apnea as an Independent Risk Factor for All-Cause Mortality: The Busselton Health Study
(2008) · Sleep · doi:10.5665/sleep/31.8.1079 · Cited by 889
Self-citationFitzgerald, K. R. (2013) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2013.06.004 · Cited by 875
Investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R., Behre, H. M., Hellstrom, W. J., Gooren, L. J., Kaufman, J. M., Legros, J.-J., Lunenfeld, B., Morales, A., et al. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0601 · Cited by 867
Excess weight and sleep-disordered breathing
Young, T., Peppard, P. E., & Taheri, S. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00587.2005 · Cited by 854
Kotronen, A., & Yki‐Järvinen, H. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.147538 · Cited by 793
Kapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791
Effects of testosterone supplementation in the aging male
Tenover, J. S. (1992) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.75.4.1092 · Cited by 768
Effects of testosterone supplementation in the aging male.
Tenover, J. S. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400877 · Cited by 702
Androgens and Cardiovascular Disease
Liu, P. Y., Death, A. K., & Handelsman, D. J. (2003) · Endocrine Reviews · doi:10.1210/er.2003-0005 · Cited by 695
Self-citationIsidori, A. M., Giannetta, E., Greco, E. A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., & Fabbri, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02339.x · Cited by 695
Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis
Araujo, A. B., Dixon, J. M., Suarez, E. A., Murad, M. H., Guey, L. T., & Wittert, G. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1137 · Cited by 671
Androgens and Coronary Artery Disease
Wu, F. C. W., & von Eckardstein, A. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0025 · Cited by 596
DHEA in elderly women and DHEA or testosterone in elderly men.
Nair, K. S., Rizza, R. A., O'Brien, P., Dhatariya, K., Short, K. R., Nehra, A., Vittone, J. L., Klee, G. G., Basu, A., Basu, R., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa054629 · Cited by 566
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 556
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553
Non-alcoholic fatty liver disease and increased risk of cardiovascular disease
Targher, G., & Arcaro, G. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.021 · Cited by 551
Jones, T. H., Arver, S., Behre, H. M., Buvat, J., Meuleman, E., Moncada, I., Morales, A. M., Volterrani, M., Yellowlees, A., Howell, J. D., et al. (2011) · Diabetes Care · doi:10.2337/dc10-1233 · Cited by 548
Cholesterol and Coronary Heart Disease: Predicting Risks by Levels and Ratios
Kinosian, B., Glick, H., & Garland, G. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-9-199411010-00002 · Cited by 519
Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518
Caminiti, G., Volterrani, M., Iellamo, F., Marazzi, G., Massaro, R., Miceli, M., Mammi, C., Piepoli, M., Fini, M., & Rosano, G. M. C. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.078 · Cited by 444
Wang, C., Nieschlag, E., Swerdloff, R. S., Behre, H. M., Hellstrom, W. J. G., Gooren, L. J., Kaufman, J., Legros, J. J., Lunenfeld, B., Morales, Á., et al. (2008) · Journal of Andrology · doi:10.2164/jandrol.108.006486 · Cited by 443
Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study
Corona, G., Rastrelli, G., Monami, M., Guay, A., Buvat, J., Sforza, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0447 · Cited by 435
Steidle, C. P., Schwartz, S. L., Jacoby, K., Sebree, T. B., Smith, T. P. L., & Bachand, R. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021058 · Cited by 409
Testosterone and Metabolic Syndrome: A Meta-Analysis Study
Corona, G., Monami, M., Rastrelli, G., Aversa, A., Tishova, Y., Saad, F., Lenzi, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01991.x · Cited by 400
Intermittent Hypoxia Causes Insulin Resistance in Lean Mice Independent of Autonomic Activity
Iiyori, N., Alonso, L. C., Li, J., Sanders, M. H., Garcia-Ocana, A., O'Doherty, R. M., Polotsky, V. Y., & O'Donnell, C. P. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200610-1527oc · Cited by 373
Type 2 diabetes mellitus and testosterone: a meta-analysis study: Type 2 diabetes and testosterone
Corona, G., Monami, M., Rastrelli, G., Aversa, A., Sforza, A., Lenzi, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01117.x · Cited by 370
Bhasin, S. (2000) · JAMA · doi:10.1001/jama.283.6.763 · Cited by 367
Wang, C. (2000) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.8.2839 · Cited by 359
Heufelder, A. E., Saad, F., Bunck, M. C., & Gooren, L. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.007005 · Cited by 349
Kalinchenko, S. Y., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J., Giltay, E. J., & Saad, F. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03845.x · Cited by 348
Androgen Treatment of Abdominally Obese Men
Mårin, P., Holmtäng, S., Gustafsson, C., Jönsson, ‡., Kvist, ‡., Elander, A., Eldh, J., Sjöström, L., Holm, G., & Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00618.x · Cited by 345
Neuroendocrine Dysfunction in Sleep Apnea: Reversal by Continuous Positive Airways Pressure Therapy*
GRUNSTEIN, R. R., HANDELSMAN, D. J., LAWRENCE, S. J., BLACKWELL, C., CATERSON, I. D., & SULLIVAN, C. E. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-352 · Cited by 302
Self-citationAllan, C. A., Strauss, B. J. G., Burger, H. G., Forbes, E. A., & McLachlan, R. I. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1291 · Cited by 298
Kalinchenko, S. Y., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J., Giltay, E. J., & Saad, F. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04105.x · Cited by 267
Aversa, A., Bruzziches, R., Francomano, D., Rosano, G., Isidori, A. M., Lenzi, A., & Spera, G. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01931.x · Cited by 265
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232
Effect of Roux-en-Y Gastric Bypass Surgery on the Sex Steroids and Quality of Life in Obese Men
Hammoud, A., Gibson, M., Hunt, S. C., Adams, T. D., Carrell, D. T., Kolotkin, R. L., & Meikle, A. W. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1598 · Cited by 207
Drager, L. F., Li, J. P., Shin, M., Reinke, C., Aggarwal, N. R., Jun, J. C., Bevans‐Fonti, S., Sztalryd, C., O’Byrne, S. M., Kroupa, O., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr097 · Cited by 175
Grunstein, R. R., Stenlöf, K., Hedner, J. A., & Sjöström, L. (1995) · PubMed · Cited by 170
Self-citationMünzer, T., Harman, S. M., Hees, P. S., Shapiro, E., Christmas, C., Bellantoni, M. F., Stevens, T. E., O’Connor, K. G., Pabst, K. M., Clair, C. S., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.8.7773 · Cited by 164
Svartberg, J., Agledahl, I., Figenschau, Y., Sildnes, T., Waterloo, K., & Jorde, R. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.19 · Cited by 160
Barrett-Connor, E., Dam, T.-T., Stone, K., Harrison, S. L., Redline, S., Orwoll, E., & for the Osteoporotic Fractures in Men Study Group (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2622 · Cited by 158
Kim, S., Kwon, H., Park, J., Cho, B., Kim, D., Oh, S., Lee, C. M., & Choi, H.-C. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-69 · Cited by 155
Testosterone and Regional Fat Distribution
Mårin, P. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00233.x · Cited by 129
Hepatic steatosis is associated with low serum testosterone and high serum DHEAS levels in men
Völzke, H., Aumann, N., Krebs, A., Nauck, M. A., Steveling, A., Lerch, M. M., Rosskopf, D., & Wallaschofski, H. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2009.00953.x · Cited by 123
Hoyos, C. M., Killick, R., Yee, B. J., Grunstein, R. R., & Liu, P. Y. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04413.x · Cited by 118
Self-citationLiu, P. Y., Wishart, S. M., & Handelsman, D. J. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8630 · Cited by 112
Self-citationNew diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD)
Ali, R., & Cusi, K. J. (2009) · Annals of Medicine · doi:10.1080/07853890802552437 · Cited by 111
Webb, C. M., Elkington, A. G., Kraidly, M., Keenan, N., Pennell, D. J., & Collins, P. D. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.09.114 · Cited by 103
Effect of Massive Weight Loss on Hypothalamic Pituitary-Gonadal Function in Obese Men*
STRAIN, G. W., ZUMOFF, B., MILLER, L. K., ROSNER, W., LEVIT, C., KALIN, M., HERSHCOPF, R. J., & ROSENFELD, R. S. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-5-1019 · Cited by 103
Effects of various modes of androgen substitution therapy on erythropoiesis.
Jockenhövel, F., Vogel, E., Reinhardt, W., & REINWEIN, D. (1997) · PubMed · Cited by 94
Testosterone therapy decreases subcutaneous fat and adiponectin in aging men
Frederiksen, L., Højlund, K., Hougaard, D. M., Mosbech, T. H., Larsen, R., Flyvbjerg, A., Frystyk, J., Brixen, K., & Andersen, M. (2012) · European Journal of Endocrinology · doi:10.1530/eje-11-0565 · Cited by 93
Effects of testosterone on Type 2 diabetes and components of the metabolic syndrome
Jones, T. H. (2010) · Journal of Diabetes · doi:10.1111/j.1753-0407.2010.00085.x · Cited by 91
Kenny, R. A., Prestwood, K. M., Gruman, C., Fabregas, G., Biskup, B., & Mansoor, G. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.7.m460 · Cited by 89
The effect of sibutramine-assisted weight loss in men with obstructive sleep apnoea
Yee, B. J., Phillips, C. L., Banerjee, D., Caterson, I., Hedner, J. A., & Grunstein, R. R. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803363 · Cited by 87
Self-citationThe Effect of Testosterone on Insulin Sensitivity in Men with Heart Failure
Malkin, C. J., Jones, T. H., & Channer, K. S. (2007) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.04.006 · Cited by 84
Haider, A., Gooren, L. J. G., Padungtod, P., & Saad, F. (2009) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0029-1202774 · Cited by 83
Lovejoy, J. C., Bray, G. A., Greeson, C. S., Klemperer, M., Morris, J., Partington, C. R., & Tulley, R. T. (1995) · PubMed · Cited by 79
Bhasin, S. (2003) · Clinical Infectious Diseases · doi:10.1086/375878 · Cited by 78
Effect of testosterone replacement therapy on arterial stiffness in older hypogonadal men
Yaron, M., Greenman, Y., Rosenfeld, J. B., Izkhakov, E., Limor, R., Osher, E., Shenkerman, G., Tordjman, K., & Stern, N. (2009) · European Journal of Endocrinology · doi:10.1530/eje-09-0052 · Cited by 78
Body composition, metabolic syndrome and testosterone in ageing men
Allan, C. A., Strauss, B. J. G., & McLachlan, R. I. (2007) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901552 · Cited by 67
Validity of a new automated software program for visceral adipose tissue estimation
Demerath, E. W., Ritter, K. J., Couch, W. P., Rogers, N. L., Moreno, G. J., Choh, A. C., Lee, M., Remsberg, K. E., Czerwiński, S., Chumlea, W. C., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803409 · Cited by 63
Phillips, C. L., Yee, B. J., Trenell, M. I., Magnussen, J. S., Wang, D., Banerjee, D., Berend, N., & Grunstein, R. R. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27595 · Cited by 46
Self-citationAndrogens, Obesity, and Sleep-Disordered Breathing in Men
Liu, P. Y., Caterson, I. D., Grunstein, R. R., & Handelsman, D. J. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.002 · Cited by 43
Self-citationSibutramine versus continuous positive airway pressure in obese obstructive sleep apnoea patients
Ferland, A., Poirier, P., & Sériès, F. (2009) · European Respiratory Journal · doi:10.1183/09031936.00167308 · Cited by 43
Munzer, T. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.8.3604 · Cited by 37
Research works printed but not linked: 7
- 1995, INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS, 19, 410
- 2008, 31, 1079
- 2008, 31, 1071
- 1992, INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS, 16, 991
- 1995, INTERNATIONAL JOURNAL OF OBESITY AND RELATED METABOLIC DISORDERS, 19, 614
- 2007, 191, 235
- Jockenh vel, 1997, European journal of medical research, 2, 293
Cited by
Sorted by citations
Xu, L., Freeman, G., Cowling, B. J., & Schooling, C. M. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-108 · Cited by 569
Kelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487
Corona, G., Rastrelli, G., Monami, M., Saad, F., Luconi, M., Lucchese, M., Facchiano, E., Sforza, A., Forti, G., Mannucci, E., et al. (2013) · European Journal of Endocrinology · doi:10.1530/eje-12-0955 · Cited by 414
Corona, G., Maseroli, E., Rastrelli, G., Isidori, A. M., Sforza, A., Mannucci, E., & Maggi, M. (2014) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2014.950653 · Cited by 297
Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
Rao, P. M., Kelly, D. M., & Jones, T. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.122 · Cited by 292
Metadata
- Authors
- Hoyos, C. M., Yee, B. J., Phillips, C. L., Machan, E. A., Grunstein, R. R., & Liu, P. Y.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Liu, Peter Y
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10
- Volume
- 167
- Issue
- 4
- Pages
- 531-541
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2143044197
- Cited by
- 145
- References
- 82
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 7 · 2018: 20 · 2017: 19 · 2016: 9 · 2015: 21 · 2014: 13 · 2013: 14
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centre National de la Recherche Scientifique
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- testosterone replacement therapy, testosterone undecanoate, obstructive sleep apnea, obesity, body composition, insulin sensitivity, visceral fat, liver fat, muscle mass, arterial stiffness, metabolic syndrome, cardiometabolic risk, hypocaloric diet, respiratory quotient, resting metabolic rate, serum lipids, menopause, hormone replacement therapy
- MeSH terms
- Body Composition, Double-Blind Method, Heart, Hormones, Humans, Male, Metabolism, Middle Aged, Obesity, Placebos, Prostate, Severity of Illness Index, Testosterone, Treatment Outcome, Sleep Apnea, Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
