Cited by 143Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentGrowth Hormone and Insulin-like Growth Factors

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Local impact of thyroid hormone inactivation

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Dentice, Monica, Salvatore, Domenico·2011·Journal of Endocrinology

DOI 10.1530/joe-11-0002

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Abstract

Deiodination is a critical process by which the minimally active thyroxine (T(4)) molecule is converted into the favorite ligand for thyroid hormone (TH) receptors, triiodothyronine (T(3)). The iodothyronine deiodinases type 1, 2, and 3 (D1, D2, and D3) constitute a potent mechanism of TH activation (D1 and D2) or inactivation (D3), which functions by tissue specifically regulating TH bioavailability. D2 and D3 are widely expressed and in a dynamically and tightly coordinated fashion, thereby allowing cells to customize their own TH activity. D3, the major T(3) and T(4) inactivating deiodinase, catalyzes their conversion to 3,3'-diiodothyronine and to reverse T(3) respectively. According to common wisdom, D3 plays a major role in lowering serum TH concentrations during development, as supported by the much wider D3 tissue expression in the embryo structures than in the adult tissues. However, several recent studies show that D3 is reexpressed in adult life in various pathophysiological contexts, which strengthens the concept that cell-specific TH inactivation is a critical mediator in cellular TH metabolism. This review focuses on the progress made in understanding the physiological function and significance of D3. It summarizes the intriguing evidence that D3 plays a pivotal role in defining local TH concentration in the developing fetus and in several conditions in adult life.

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Authors: Dentice, M., & Salvatore, D.
Affiliations: Federico II University Hospital (IT)
Corresponding author: Dentice, Monica
ORCID: Dentice, Monica
Salvatore, Domenico
Venue: Journal of Endocrinology
Publisher: Bioscientifica
Published: 2011-03-11
Volume: 209
Issue: 3
Pages: 273-282
ISSN: 0022-0795 (ISSN-L)
1479-6805
DOI: 10.1530/joe-11-0002
OpenAlex: W2318017892
Cited by: 143
References: 94
Citations by year: 2026: 4 · 2025: 11 · 2024: 9 · 2023: 5 · 2022: 4 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 11 · 2017: 16 · 2016: 6 · 2015: 8 · 2014: 8 · 2013: 14 · 2012: 13
FWCI: 1.73
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Endocrinology (publishedVersion)
PubMed (publishedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Funders: Associazione Italiana per la Ricerca sul Cancro
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: thyroid hormone inactivation, triiodothyronine, thyroxine, thyroid hormone receptor, reverse T3, 3,3'-diiodothyronine, fetal thyroid development
MeSH terms: Aging, Animals, Humans, Iodide Peroxidase, Thyroid Hormones, Thyroxine, Triiodothyronine

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