Cited by 412Infant Nutrition and HealthBreastfeeding Practices and InfluencesMicrobial Metabolites in Food Biotechnology

The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.

Breast Milk Oligosaccharides: Structure-Function Relationships in the Neonate

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Abstract

In addition to providing complete postnatal nutrition, breast milk is a complex biofluid that delivers bioactive components for the growth and development of the intestinal and immune systems. Lactation is a unique opportunity to understand the role of diet in shaping the intestinal environment including the infant microbiome. Of considerable interest is the diversity and abundance of milk glycans that are energetically costly for the mammary gland to produce yet indigestible by infants. Milk glycans comprise free oligosaccharides, glycoproteins, glycopeptides, and glycolipids. Emerging technological advances are enabling more comprehensive, sensitive, and rapid analyses of these different classes of milk glycans. Understanding the impact of inter- and intraindividual glycan diversity on function is an important step toward interventions aimed at improving health and preventing disease. This review discusses the state of technology for glycan analysis and how specific structure-function knowledge is enhancing our understanding of early nutrition in the neonate.

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Crossref · 10.1146/annurev-nutr-071813-105721

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Research works printed but not linked: 6

  1. Alfaleh K, 2011, Cochrane Database Syst. Rev., 3, CD005496
  2. Bu H, 2007, J. Clin. Invest., 117, 3673
  3. 10.1007/978-1-4615-1371-1_38 · DOI
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  6. Zivkovic AM, 2013, Funct. Food Rev., 5, 3

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Metadata

Authors
Smilowitz, J. T., Lebrilla, C. B., Mills, D. A., German, J. B., & Freeman, S. L.
Affiliations
  • Department of Food Science and Technology,
  • Department of Chemistry, and
  • University of California, Davis (US)
Venue
Annual Review of Nutrition
Published
2014-07-17
Volume
34
Issue
1
Pages
143-169
ISSN
  • 0199-9885 (ISSN-L)
  • 1545-4312
OpenAlex
W2157542971
Cited by
410
References
154
Citations by year
2026: 15 · 2025: 19 · 2024: 30 · 2023: 33 · 2022: 27 · 2021: 57 · 2020: 64 · 2019: 51 · 2018: 36 · 2017: 29 · 2016: 33 · 2015: 15 · 2014: 1
FWCI
2.98
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • Bill and Melinda Gates Foundation
  • California Dairy Research Foundation
  • National Institutes of Health
  • University of California, Davis
  • National Center for Complementary and Integrative Health (R01AT007079, R21AT006180)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065122, R01HD061923, R01HD059127)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Medicine › Epidemiology › Breastfeeding Practices and Influences
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
human milk oligosaccharides, structure-function relationship, neonatal nutrition, infant microbiome, intestinal development, immune system development, glycoproteins, glycopeptides, glycolipids, lactation
MeSH terms
Bifidobacterium, Breast Feeding, Carbohydrate Sequence, Child Development, Female, Glycolipids, Glycopeptides, Glycoproteins, Humans, Immunity, Innate, Infant, Newborn, Intestinal Mucosa, Lactation, Male, Milk Proteins, Milk, Human, Models, Biological, Oligosaccharides

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